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- 저자 : Ngo Minh Ly (검색결과 2 건)
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Immunohistochemical expression in idiopathic inflammatory myopathies at a single center in Vietnam
Dat Quoc Ngo,Si Tri Le,Khanh Hoang Phuong Phan,Thao Thi Phuong Doan,Linh Ngoc Khanh Nguyen,Minh Hoang Dang,Thien Thanh Ly,Thu Dang Anh Phan 대한병리학회 2024 Journal of Pathology and Translational Medicine Vol.58 No.4
Background: The identification of idiopathic inflammatory myopathies (IIMs) requires a comprehensive analysis involving clinical manifestations and histological findings. This study aims to provide insights into the histopathological and immunohistochemical aspects of IIMs. Methods: This retrospective case series involved 56 patients diagnosed with IIMs at the Department of Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, from 2019 to 2023. The histology and immunohistochemical expression of HLA-ABC, HLA-DR, C5b-9, Mx1/2/3, and p62 were detected. Results: We examined six categories of inflammatory myopathy, including immunemediated necrotizing myopathy (58.9%), dermatomyositis (DM; 23.2%), overlap myositis (8.9%), antisynthetase syndrome (5.4%), inclusion body myositis (IBM; 1.8%), and polymyositis (1.8%). The average age of the patients was 49.7 ± 16.1 years, with a female-to-male ratio of 3:1. Inflammatory cell infiltration in the endomysium was present in 62.5% of cases, perifascicular atrophy was found in 17.8%, and fiber necrosis was observed in 42 cases (75.0%). Rimmed vacuoles were present in 100% of cases in the IBM group. Immunohistochemistry showed the following positivity rates: HLA-ABC (89.2%), HLA-DR (19.6%), C5b-9 (57.1%), and Mx1/2/3 (10.7%). Mx1/2/3 expression was high in DM cases. p62 vacuole deposits were noted in the IBM case. The combination of membrane attack complex and major histocompatibility complex I helped detect IIMs in 96% of cases. Conclusions: The diagnosis of IIMs and their subtypes should be based on clinical features and histopathological characteristics. Immunohistochemistry plays a crucial role in the diagnosis and differentiation of these subgroups.
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Quan T. Lai,Vu Anh Tuan,Dinh Kim Dieu,Alexander B. Orfinger,Ngo Minh Ly,Nguyen Thanh Ha,Trinh Truong Giang 한국해양과학기술원 2022 Ocean science journal Vol.57 No.4
This study aimed to analyze the sex ratio, spawning seasons, length at first maturity, length distribution, length–weight relationship, and relative condition factor of Cultellus maximus (Gmelin, 1791) in Southern Vietnam. A total of 1037 individuals of C. maximus were collected at 3 sampling sites from June, 2019 to June, 2020. The sex ratio was found to be female biased in Can Gio and male biased in Phu Tan and Ngoc Hien. The clam spawns throughout the year, peaking at Q2 and Q3 during the rainy season. Pooled length at first maturity was 10.12 cm (9.65–10.49 cm CI 95%, P-value < 2.2·10–16). The length–weight relationship indicates positive allometric growth. This study suggests that imposing a minimum harvest size limit on C. maximus using the length at first maturity as reference and with harvest seasons in Q1 in Ngoc Hien and Can Gio and Q2 or Q3 in Phu Tan would be ideal for consumption of this species.
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