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Yamaguchi, Eiki,Fukushi, Fumio,Hirayama, Naoki,Kubo, Takemi,Kubo, Yoshinobu Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.19 No.2
For reducing construction cost, two-plate-girder bridges are getting popular in Japan. This type of bridge employs a PC slab, which is often cast-in-place. In such a case, concrete is not usually cast over the whole slab at one time: some portions are constructed earlier than the rest. Therefore, a construction joint is inevitably created. Due to the drying shrinkage of concrete, tension stress may occur in concrete slab. High tensile stress can be expected near the construction joint where concretes with different ages meet. Moreover, prestressing is not applied over the whole length of slab at one time. This may also serve as a source of tensile stress in the slab. Thus there is a chance that cast-in-place PC slab, especially near the construction joint, may be subjected to tensile cracking. In the present study, stress states near the construction joint in the cast-in-place PC slab of a two-plate-girder bridge are investigated numerically. The finite element method is employed and the three-dimensional analysis is conducted to see the influence of dry shrinkage and prestressing. The stress states in the PC slab thus obtained are discussed. The simplified model of a plate girder for this class of analysis is also proposed.
Plengsuriyakarn, Tullayakorn,Matsuda, Naoki,Karbwang, Juntra,Viyanant, Vithoon,Hirayama, Kenji,Na-Bangchang, Kesara Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
Opisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) is an important cancer in the Great Mekong region, particularly in Thailand. Limitations of treatment options and the lack of an effective diagnostic tool for early detection of CCA are major concerns for the control of this type of cancer. The aim of the study was to investigate anti-CCA activity of the ethanolic extract of Atractylodes lancea (Thunb.) DC., and the applicability of positron emission tomography-computed tomography (PET-CT) as a tool for detection and monitoring the progression of CCA in Opisthorchis viverrini (OV)/dimethylnitrosamine (DMN)-induced CCA hamsters. Male Syrian hamsters were used for toxicity tests and anti-CCA activity evaluation. Development of CCA was induced by initial feeding of 50 metacercariae of OV, followed by drinking water containing 12.5 ppm of DMN in hamsters. The ethanolic extract of A. lancea (Thunb.) DC. was administered orally for 30 days. PET-CT was performed every 4 weeks after initiation of CCA using 18F-fluorodeoxyglucose ($^{18}F-FDG$). Results from the present study suggest that the ethanolic extract of A. lancea (Thunb.) DC. rhizome exhibited promising anti-CCA activity and safety profile in the OV/DMN-induced hamster model. To successfully apply PET-CT as a tool for early detection of tumor development and progression, modification of radiolabeling approach is required to improve its specificity for CCA cells.