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Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway
( Yue Lu1 ),( Xian Li ),( Young Na Park ),( Okyun Kwon ),( Donggen Piao ),( Young Chae Chang ),( Cheorl Ho Kim ),( Eunkyung Lee ),( Jong Keun Son ),( Hyeun Wook Chang ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.3
The aim of this study was to determine whether britanin, isolated from the flowers of Inula japonica (Inulae Flos), modulates the generation of allergic inflammatory mediators in activated mast cells. To understand the biological activity of britanin, the authors investigated its effects on the generation of prostaglandin D2 (PGD2), leukotriene C4 (LTC4), and degranulation in IgE/Ag-induced bone marrow-derived mast cells (BMMCs). Britanin dose dependently inhibited degranulation and the generations of PGD2 and LTC4 in BMMCs. Biochemical analyses of IgE/Ag-mediated signaling pathways demonstrated that britanin suppressed the phosphorylation of Syk kinase and multiple downstream signaling processes, including phospholipase Cγ1 (PLCγ1)-mediated calcium influx, the activation of mitogen-activated protein kinases (MAPKs; extracellular signal-regulated kinase 1/2, c Jun NH2-terminal kinase and p38), and the nuclear factor-κB (NF-κB) pathway. Taken together, the findings of this study suggest britanin suppresses degranulation and eicosanoid generation by inhibiting the Syk-dependent pathway and britanin might be useful for the treatment of allergic inflammatory diseases.
나현혜,이루리,이지윤,윤지혜,김윤정 서울여자대학교 컴퓨터과학연구소 2011 정보기술논문지 Vol.9 No.-
본 논문에서는 웹서버 보안 취약점 점검 방안에 대한 연구 동향을 조사하고 분석한다. 우선, 한국인터넷진흥원 인터넷침해대응센타에서 발표한 웹 취약점 공격동향에 대하여 살펴본다. 다음으로, 취약점 점검 항목에는 어떠한 것들이 있는지에 대해 소개하고, 예상 공격 시나리오와 그 공격들을 방어하는 방법에 대해 설명한다. 이들 점건 항목들은 주로 OWASO(Open Web Application Security Project)를 기반으로 한다. 그리고, 현재 이용되고 있는 웹 서버 보안 취약점 점건 도구들에 대하여 살펴본다. 본 연구 결과를 이용하여 웹서버를 안전하게 관리함으로써, 안전한 컴퓨터 및 네트워크 환경에 기여하고자 한다.
Surface Characterization of the Activated Carbon Fibers After Plasma Polymerization of Allylamine
Lu, Na,Tang, Shen,Ryu, Seung-Kon,Choi, Ho-Suk Korean Carbon Society 2005 Carbon Letters Vol.6 No.4
Plasma polymerization of allylamine subsequently after plasma pre-treatment was conducted on the activated carbon fibers (ACFs) for the immobilization of amine groups in the surface of ACFs. The change of structural properties of ACFs with respect to different polymerization conditions was investigated through BET method. The change of surface morphologies of ACFs with respect to different plasma polymerization power was also studied through AFM. It was found that the structural properties such as specific surface area and micropore volume could be optimized under certain plasma deposition conditions. It was reckoned that treatment and deposition showed adverse effect on plasma polymerization, in which the former developed the micro-structures of the ACFs and the latter tended to block the micro pores. The Fourier transform infrared spectroscopy (FTIR) revealed that the poly(allylamine) was successfully immobilized on the surface of ACFs and the amount of the deposited polymer layer was related to the plasma polymerization power. SEM results showed that the plasma deposited polymer layer were small and homogenously distributed. The size and the distribution of particles deposited were closely related to the plasma polymerization power, too.
Surface Characterization of the Activated Carbon Fibers After Plasma Polymerization of Allylamine
Na Lu,Shen Tang,Seung-Kon Ryu,Ho-Suk Choi 한국탄소학회 2005 Carbon Letters Vol.6 No.4
Plasma polymerization of allylamine subsequently after plasma pre-treatment was conducted on the activated carbon fibers (ACFs) for the immobilization of amine groups in the surface of ACFs. The change of structural properties of ACFs with respect to different polymerization conditions was investigated through BET method. The change of surface morphologies of ACFs with respect to different plasma polymerization power was also studied through AFM. It was found that the structural properties such as specific surface area and micropore volume could be optimized under certain plasma deposition conditions. It was reckoned that treatment and deposition showed adverse effect on plasma polymerization, in which the former developed the micro-structures of the ACFs and the latter tended to block the micro pores. The Fourier transform infrared spectroscopy (FTIR) revealed that the poly(allylamine) was successfully immobilized on the surface of ACFs and the amount of the deposited polymer layer was related to the plasma polymerization power. SEM results showed that the plasma deposited polymer layer were small and homogenously distributed. The size and the distribution of particles deposited were closely related to the plasma polymerization power, too.
Na-na Li,Jian-liang Lu,Xin-qiang Zheng,Yue-rong Liang 한국차학회 2015 한국차학회지 Vol.- No.S
Albino tea cultivars have precious white shoots or yellow shoots and are widely cultivated in China to produce high quality green tea with fresh taste and high aroma, including temperature-sensitive albino mutants and light-sensitive albino mutants. Physiological and biochemical indicators showed that the levels of pigments, total catechins and caffeine decreased, the content of total amino acids, especially theanine increased, and the chloroplast structure were abnormal in albino leaves; molecular studies displayed that expression of genes encoding chloroplast structure and chlorophyll synthesis, such as light harvesting chlorophyll a/b-binding protein, glutamyl-tRNA reductase, Mg-chelatase H subunit, S-adenosylmethionine synthetase and glutamine synthetase, suppressed in albino period
Ni-Na Song,Xu Huang,Hong-Li Lu,Chen Lu,Jie Chen,Wen-Xie Xu 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.2
Background/AimsThe gastrointestinal symptom of diabetes mellitus, chronic constipation, seriously affects patients’ life. Whereas, the mechanism of chronic constipation is still ambiguous, resulting in a lack of effective therapies for this symptom. As a part of the smooth muscle cells, interstitial cells of Cajal, and platelet-derived growth factor receptor alpha-positive (PDGFRα+) cells syncytium (SIP syncytium), PDGFRα+ cells play an important role in regulating colonic motility. According to our previous study, in PDGFRα+ cells in colons of diabetic mice, the function of the P2Y1 purinergic receptor/type 3 small-conductance calcium-activated potassium (SK3) channel signaling pathway is strengthened, which may lead to colonic dysmotility. The purpose of this study is to investigate the changes in SK3 channel properties of PDGFRα+ cells in diabetic mice. MethodsWhole-cell patch clamp, Western blotting, superoxide dismutase activity measurement, and malondialdehyde measurement were main methods in the present study. ResultsThe present study revealed that when dialysed with low calcium ion (Ca2+) solution, the SK3 current density was significantly decreased in PDGFRα+ cells from diabetic mice. However, the SK3 current density in PDGFRα+ cells was enhanced from diabetic mice when dialysed with high Ca2+ solution. Moreover, hydrogen peroxide-treatment mimicked this phenomenon in SK3 transgenic HEK293 cells. The subunit of SK3 channels, protein kinase CK2, was up-regulated in colonic muscle layers and hydrogen peroxide-treated HEK293 cells. Additionally, protein phosphatase 2A, the subunit of SK3 channels, was not changed in streptozotocin-treated mouse colons or hydrogen peroxide-treated HEK293 cells. ConclusionThe diabetic oxidative stress-induced upregulation of CK2 contributed to modulating SK3 channel sensitivity to Ca2+ in colonic PDGFRα+ cells, which may result in colonic dysmotility in diabetic mice.
Computed Tomography Manifestations of Histologic Subtypes of Retroperitoneal Liposarcoma
Lu, Jing,Qin, Qin,Zhan, Liang-Liang,Yang, Xi,Xu, Qing,Yu, Jing,Dou, Li-Na,Zhang, Hao,Yang, Yan,Chen, Xiao-Chen,Yang, Yue-Hua,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Objective: Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20% of all mesenchymal malignancies, often occurring in deep soft tissue of retroperitoneal space. Accurate preoperative diagnosis is therefore necessary. We explored whether computed tomography (CT) could be used to differentiate between the various types of retroperitoneal liposarcoma (RPLS). Method: Forty-seven cases of RPLS, diagnosed surgically and histologically, were analyzed retrospectively. CT features were correlated with postoperative pathological appearance. Results: The study radiologist identified 29, 11, 2, 2 and 3 RPLS as atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL), dedifferentiated liposarcoma (DDL), myxoid/round cell liposarcoma (ML/RCL), pleomorphic liposarcoma (PL) and mixed-type liposarcoma. Analysis of CT scans revealed the following typical findings of the different subtypes of RPLS: ALT/WDL was mainly visible as a well-delineated fatty hypodense tumor with uniform density and integrity margin; DDL was marked by the combination of focal nodular density and hypervascularity. ML/RCL, PL and mixed liposarcoma showed malignant biological behaviour and CT findings need further studies. Conclusions: CT scanning can reveal important details including internal components, margins and surrounding tissues. Based on CT findings, tumor type can be roughly evaluated and biopsy location and therapeutic scheme guided.
Lu Liu,Xiumei Zhang,Dianrong Sun,Tianxiang Gao,Na Song 한국해양과학기술원 2019 Ocean science journal Vol.54 No.2
The population genetic studies of marine fishes usually show complex patterns of genetic differentiation which were influenced by both historical process and contemporary gene flow. Genetic structure of eight different populations for eastern keelback mullet, Liza affinis, collected from the coast along eastern and southern China, was examined using six microsatellite loci. We found strong genetic similarities among most of the samples except the Dongguan population and most microsatellite variation was found within populations. All loci were characterized by high genetic variability with expected heterozygosities ranging from 0.871 to 0.928. The Bayesian cluster analysis of the microsatellite data detected four genetic groups with no relation to geographic areas. The bottleneck results also showed no significant values. Based on these data we postulated that complex marine currents and larval dispersal shaped the genetic structured of studied populations. The present study illustrated the importance of understanding the biological significance of genetic differentiation when using molecular data in identifying units for management and protection.