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Kim, Hojeong,Kim, Changsoo,Seo, Sang Won,Na, Duk L.,Kim, Hee Jin,Kang, Mira,Shin, Hee-Young,Cho, Seong Kyung,Park, Sang eon,Lee, Jeongmin,Hwang, Jung Won,Jeon, Seun,Lee, Jong-Min,Kim, Geon Ha,Cho, Han Cambridge University Press 2015 INTERNATIONAL PSYCHOGERIATRICS - Vol.27 No.1
<B>ABSTRACT</B><B>Background:</B><P>There is increasing evidence of a relationship between underweight or obesity and dementia risk. Several studies have investigated the relationship between body weight and brain atrophy, a pathological change preceding dementia, but their results are inconsistent. Therefore, we aimed to evaluate the relationship between body mass index (BMI) and cortical atrophy among cognitively normal participants.</P><B>Methods:</B><P>We recruited cognitively normal participants (<I>n</I> = 1,111) who underwent medical checkups and detailed neurologic screening, including magnetic resonance imaging (MRI) in the health screening visits between September 2008 and December 2011. The main outcome was cortical thickness measured using MRI. The number of subjects with five BMI groups in men/women was 9/9, 148/258, 185/128, 149/111, and 64/50 in underweight, normal, overweight, mild obesity, and moderate to severe obesity, respectively. Linear and non-linear relationships between BMI and cortical thickness were examined using multiple linear regression analysis and generalized additive models after adjustment for potential confounders.</P><B>Results:</B><P>Among men, underweight participants showed significant cortical thinning in the frontal and temporal regions compared to normal weight participants, while overweight and mildly obese participants had greater cortical thicknesses in the frontal region and the frontal, temporal, and occipital regions, respectively. However, cortical thickness in each brain region was not significantly different in normal weight and moderate to severe obesity groups. Among women, the association between BMI and cortical thickness was not statistically significant.</P><B>Conclusions:</B><P>Our findings suggested that underweight might be an important risk factor for pathological changes in the brain, while overweight or mild obesity may be inversely associated with cortical atrophy in cognitively normal elderly males.</P>
Park, Sang Eon,Kim, Hojeong,Lee, Jeongmin,Lee, Na Kyung,Hwang, Jung Won,Yang, Jin-ju,Ye, Byoung Seok,Cho, Hanna,Kim, Hee Jin,Kim, Yeo Jin,Jung, Na-Yeon,Son, Tae Ok,Cho, Eun Bin,Jang, Hyemin,Jang, Eun Cambridge University Press 2016 INTERNATIONAL PSYCHOGERIATRICS - Vol.28 No.1
<B>ABSTRACT</B><B>Background:</B><P>Decreased hemoglobin levels increase the risk of developing dementia among the elderly. However, the underlying mechanisms that link decreased hemoglobin levels to incident dementia still remain unclear, possibly due to the fact that few studies have reported on the relationship between low hemoglobin levels and neuroimaging markers. We, therefore, investigated the relationships between decreased hemoglobin levels, cerebral small-vessel disease (CSVD), and cortical atrophy in cognitively healthy women and men.</P><B>Methods:</B><P>Cognitively normal women (<I>n</I> = 1,022) and men (<I>n</I> = 1,018) who underwent medical check-ups and magnetic resonance imaging (MRI) were enrolled at a health promotion center. We measured hemoglobin levels, white matter hyperintensities (WMH) scales, lacunes, and microbleeds. Cortical thickness was automatically measured using surface based methods. Multivariate regression analyses were performed after controlling for possible confounders.</P><B>Results:</B><P>Decreased hemoglobin levels were not associated with the presence of WMH, lacunes, or microbleeds in women and men. Among women, decreased hemoglobin levels were associated with decreased cortical thickness in the frontal (Estimates, 95% confidence interval, −0.007, (−0.013, −0.001)), temporal (−0.010, (−0.018, −0.002)), parietal (−0.009, (−0.015, −0.003)), and occipital regions (−0.011, (−0.019, −0.003)). Among men, however, no associations were observed between hemoglobin levels and cortical thickness.</P><B>Conclusion:</B><P>Our findings suggested that decreased hemoglobin levels affected cortical atrophy, but not increased CSVD, among women, although the association is modest. Given the paucity of modifiable risk factors for age-related cognitive decline, our results have important public health implications.</P>
Jaehong Lee(이재홍),Seung-Hoon Um(엄승훈),Min-Young Na(나민영),Hye-Jung Chang(장혜정),Hyung-Seop Han(한형섭),Yu-Chan Kim(김유찬),Hojeong Jeon(전호정) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
Ti alloy, which be commonly used in medical implants for hard tissue, has high corrosion resistance from body fluid. Nevertheless, Ti alloy has been considered as a bio-inert material which might form fibrous tissue and have low osseointegration because of Ti oxide film formed naturally in oxygen environment. To improve the osseointegration, surface roughness and structure modification of bio-inert Ti alloy has been attempted. And currently, the surface modification by laser has been developed for laser induced periodic surface structure (LIPSS) to provide nano/micro scale cell favor morphology to bone cells. However, the bio-inert property inherently cannot be changed to bio-active. In this study, using LIPSS, we coated hydroxyapatite on surface of Ti6Al4V to provide nano/micro scale bio-active morphology to bone cells. The hydroxyapatite coatings on LIPSS were observed and analyzed by SEM, EDX, XRD and TEM. Additionally, the improved cell attachment was showed on LIPSS coated with hydroxyapatite.
Kim, Geon Ha,Im, Kiho,Kwon, Hunki,Seo, Sang Won,Ye, Byoung Seok,Cho, Hanna,Noh, Young,Lee, Jong Min,Kim, Sung Tae,Park, Sang Eon,Kim, Hojeong,Hwang, Jung Won,Kang, Sue J.,Jeong, Jee Hyang,Na, Duk L. Frontiers Media S.A. 2016 FRONTIERS IN AGING NEUROSCIENCE Vol.8 No.-
<P>The purpose of this study was to demonstrate the potential alterations in structural network properties related to physical activity (PA) in healthy elderly. We recruited 76 elderly individuals with normal cognition from Samsung Medical Center in Seoul, Korea. All participants underwent the Cambridge Neuropsychological Test Automated Battery and 3.0T brain magnetic resonance imaging (MRI). Participants were subdivided into quartiles according to the International Physical Activity Questionnaire scores, which represents the amount of PA. Through graph theory based analyses, we compared global and local network topologies according to PA quartile. The higher PA group demonstrated better performance in speed processing compared to the lower PA group. Regional nodal strength also significantly increased in the higher PA group, which involved the bilateral middle frontal, bilateral inferior parietal, right medial orbitofrontal, right superior, and middle temporal gyri. These results were further replicated when the highest and the lowest quartile groups were compared in terms of regional nodal strengths and local efficiency. Our findings that the regional nodal strengths associated with the attentional network were increased in the higher PA group suggest the preventive effects of PA on age-related cognitive decline, especially in attention.</P>