여고생의 자아 이미지와 의복구매 행동에 관한 연구

全英信,韓明淑 服飾文化學會 1998 服飾文化硏究 Vol.6 No.1

The objective of this study is to measure self-image of adolescence, analyze empirically clothing-purchasing-behavior of adolescence and clarify correlation of two variables, self-image and clothing-purchasing-behavior, For this purpose, the techinques involve theoretical studies and researches based on historical data obtained from previous related studies and surveys. 431 high school female students who reside in Seoul are asked to answer selected survey questions to examine three aspects, clothing-purchasing-behavior, self-image and demographics. The evaluation of surveyed information is analyzed by statistical techniques to improve the accuracy of data, Statistical methods used are as follows: Descriptives (frequency, mean, percentage), Factor Analysis(varimax rotation), Crosstabs(Chi-square), T-test, One-Way ANOVA, Correlation Analysis, Reliability Analysis and Duncan's Multiple Range Test. The major results of this study were as follows : Firstly, there is a discrepancy between real self-image and ideal self-image. Furthermore more significant differences is seen from physical aspects than psychological aspects, Consequently, research proves that the difference derived from their ideal situation and leads to psychological unstableness, In addition, making their real self-image is dependent upon several elements such things as family economic level, pocket money, expenditure on clothing. Therefore, it is critical to combine all factors in order to decide how much to spend for children's clothing and pocket money in parents point of view. Secondly, research shows that there is correlated relationship between average expenditure on clothing and presence of mother's job. Average expenditure on clothing is, generally, influenced by vogue which is tend to be changed seasonally. It, also, shows that there is positive linear regression between expenditure on clothe and sensitivity for vogue. That is to say, dependent vriable, expenditure on clothing, is varied as independent variable, sensitivity for vogue, changes, Female high school students are likely to give much value on brand, moreover people who are spending more money on clothes have higher tendencies in prompt purchases than who are not. Thirdly, the analysis of clothing-purchasing-behavior and self-image shows that the difference between real self-image and ideal self-image draws the main reason of dissatisfaction after purchase of clothes. As a consequence, their unfilled needs lead them to keep making another purchase to satisfy themselves. Therefore, it is strongly recommended that parents' advices and directions on their children's money spending on clothes are imperative to establish well-behaved purchasing patterns.

흰쥐에서 염화비닐 폭로수준에 따른 소변내 thiodiglycolic acid 농도의 변화

왕승준,차봉석,노재훈,신동천,김명수,전근재 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : It is the objective of this research to identify the variation of thiodiglycolic acid(TdGA) in urine with vinyl chloride monamer(VCM) exposure levels through methylation. Methods : After rats were exposed to vinyl chloride monomer of 4 levels, 0㎎/㎥, 50㎎/㎥, 150㎎/㎥, 500㎎/㎥, respectively, of which urine was sampled in each sampling time of 0 hour, 2 hours, 4 hours, 8 hours, 16 hours, 36 hours, 48 hours. After urine had been methylated with diazomethane in the preliminary experiment and the peak of 146 m/z had been verified, the main experiment was done. Results : In the variation of TdGA with sampling times, concentration of TdGA increased rapidly in 4 hours and then decreased after 8 hours. When the variation of urinary TdGA concentration in urine according to exposure level of VGM was verified through Kruskal-Wallis statistical method at each sampling time, the significant increment with the exposure levels at 2 hours, 4 hours, 8 hours after exposure was clarified. Conclusion : TdGA concentration in urine with increment of VCM exposure level increased, especially significantly at 2 hours, 4 hours, 8 hours of sampling time.

[Preclinical experience in stem cell therapy for digestive tract diseases].

Jeon, Myung Shin,Hong, Soon Sun Korean Society of Gastroenterology 2011 대한소화기학회지 Vol.58 No.3

<P>Adult stem cells are multipotent and self-renewing cells that contain several functions; i) migration and homing potential: stem cells can migrate to injured and inflamed tissues. ii) differentiation potential: stem cells which migrated to injured tissues can be differentiated into multiple cell types for repairing and regenerating the tissues. iii) immunomodulatory properties: stem cells, especially mesenchymal stem cells can suppress immune system such as inflammation. All those characteristics might be useful for the treatment of the digestive tract diseases which are complex and encompass a broad spectrum of different pathogenesis. Preclinical stem cell therapy showed some promising results, especially in liver failure, pancreatitis, sepsis, and inflammatory bowel disease. If we can understand more about the mechanism of stem cell action, stem cell therapy can become a promising alternative treatment for refractory digestive disease in the near future. In this review, we summarized current preclinical experiences in diseases of the digestive tract using stem cells. (Korean J Gastroenterol 2011;58:133-138).</P>

소화기질환에서의 줄기세포 치료에 대한 전임상 연구

전명신 ( Myung Shin Jeon ),홍순선 ( Soon Sun Hong ) 대한소화기학회 2011 대한소화기학회지 Vol.58 No.3

Adult stem cells are multipotent and self-renewing cells that contain several functions; i) migration and homing potential: stem cells can migrate to injured and inflamed tissues. ii) differentiation potential: stem cells which migrated to injured tissues can be differentiated into multiple cell types for repairing and regenerating the tissues. iii) immunomodulatory properties: stem cells, especially mesenchymal stem cells can suppress immune system such as inflammation. All those characteristics might be useful for the treatment of the digestive tract diseases which are complex and encompass a broad spectrum of different pathogenesis. Preclinical stem cell therapy showed some promising results, especially in liver failure, pancreatitis, sepsis, and inflammatory bowel disease. If we can understand more about the mechanism of stem cell action, stem cell therapy can become a promising alternative treatment for refractory digestive disease in the near future. In this review, we summarized current preclinical experiences in diseases of the digestive tract using stem cells. (Korean J Gastroenterol 2011;58:133-138)

건조효율 향상을 위한 마이크로파 감응형 최적 고온발열체 선정

신명섭(Myung-Seop Shin),전미진(Mijin Jeon),정성대(Seong-Dae Jeong),전용우(Yong-Woo Jeon) 한국신재생에너지학회 2017 한국신재생에너지학회 학술대회논문집 Vol.2017 No.5

Poly-γ-Glutamic Acid Induces Apoptosis via Reduction of COX-2 Expression in TPA-Induced HT-29 Human Colorectal Cancer Cells

Shin, Eun Ju,Sung, Mi Jeong,Park, Jae Ho,Yang, Hye Jeong,Kim, Myung Sunny,Hur, Haeng Jeon,Hwang, Jin-Taek MDPI 2015 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.16 No.4

<P>Poly-γ-glutamic acid (PGA) is one of the bioactive compounds found in <I>cheonggukjang</I>, a fast-fermented soybean paste widely utilized in Korean cooking. PGA is reported to have a number of beneficial health effects, and interestingly, it has been identified as a possible anti-cancer compound through its ability to promote apoptosis in cancer cells, although the precise molecular mechanisms remain unclear. Our findings demonstrate that PGA inhibits the pro-proliferative functions of the phorbol ester 12-<I>O</I>-tetradecanoylphorbol-13-acetate (TPA), a known chemical carcinogen in HT-29 human colorectal cancer cells. This inhibition was accompanied by hallmark apoptotic phenotypes, including DNA fragmentation and the cleavage of poly (ADP-ribose) polymerase (PARP) and caspase 3. In addition, PGA treatment reduced the expression of genes known to be overexpressed in colorectal cancer cells, including cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS). Lastly, PGA promoted activation of 5' adenosine monophosphate-activated protein (AMPK) in HT-29 cells. Taken together, our results suggest that PGA treatment enhances apoptosis in colorectal cancer cells, in part by modulating the activity of the COX-2 and AMPK signaling pathways. These anti-cancer functions of PGA make it a promising compound for future study.</P>

Pilot Study on Microwave Dryer for Dehydration of Sewage Sludge Cake

Myung Seop Shin,Yong-Woo Jeon,Seohyeon Pak,Hyun-Jung Kim 한국폐기물자원순환학회 2015 한국폐기물자원순환학회 학술대회 Vol.2015 No.05

Dewatering for reduction of moisture content in sludge cake is one of the main procedure in sludge treatment processing. Through dehydration process, the volume of sludge cake are substantially decreased. It led efficiency improvement of further processing such as transport and disposal of sludge as well as drying cake could be utilized as solid refuse fuel. Microwave dryer is energy efficient process in comparison with thermal types. For these reason, we developed microwave dryer for real field applications. Firstly, with 4kW scale microwave dryer, operation conditions were optimized in terms of generator power, shape of drying champer, and height of microwave generator. Based on the results, 10kW scale microwave dryer was designed and manufactured successfully.

P063 : The relationship between Filaggrin gene variations and minor features of atopic dermatitis

( Myung Shin Kim ),( Woo Seok Jeon ),( Joon Hong Park ),( Ji Yeon Kim ),( Yong Goo Kim ),( Mi Sun Park ),( Kyung Eun Jung ),( Hei Sung Kim ),( Young Min Park ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Skin barrier defects caused by FLG gene mutations are thought to play a crucial role in the pathogenesis of AD-associated minor characteristics. Objectives: In this study, we tried to evaluate if FLG mutations or single nucleotide variations (SNVs) can serve as a predictor for minor features of AD. Methods: In total, 68 patients with AD were analyzed for the FLG mutations and SNVs using full sequencing via overlapping long-range PCR method. The allele frequencies in AD-associated minor features were compared to those in controls using the Chi-square test and logistic regression analysis. Results: Fourteen indistinct loss-of-function mutations in the FLG were identified from 12 AD patients (17.6%), which were all located in exon 3. Haplotype analysis revealed that Block 2 CATAGCGGCCG and TGCGCTGAGGG haplotypes showed a significant association with development of non-specific hand or foot dermatitis (NS-HFD) (P = 0.014 and 0.017, respectively). Block 3 CCGCACGAGCATCTTATGA and CTGTGTAGCCCTCCCGTGG haplotypes also revealed a significant association with NS-HFD (P = 0.008 and 0.026, respectively).We found Block 2 TGCGCTGAGGT and CATAGCGGCGG, Block 3 CTGTGTAGCCCTCCCGTGG and CCGCACGAGCATCTTATGA, and Block 4 TGATT haplotypes were associated with development of scalp scale (P=0.016, 0.038, 0.007, 0.019, 0.005, respectively). Conclusion: Our results demonstrated that the FLG SNVs may confer susceptibility to the minor features including NS-HFD and scalp scale.

TGFβ mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation

Shin, Dong-Myung,Jeon, Ju-Hong,Kim, Chai-Wan,Cho, Sung-Yup,Lee, Hye-Jin,Jang, Gi-Yong,Jeong, Eui Man,Lee, Dong-Sup,Kang, Ja-Heon,Melino, Gerry,Park, Sang-Chul,Kim, In-Gyu Federation of American Society for Experimental Bi 2008 The FASEB Journal Vol.22 No.7

<P>Transglutaminase 2 (TGase2) is a ubiquitously expressed enzyme that catalyzes irreversible post-translational modification of protein, forming cross-linked protein aggregates. We previously reported that intracellular TGase2 is activated by oxidative stress. To elucidate the functional role of TGase2 activation in cells under the oxidatively stressed condition, we identified the mediator that activates TGase2. In this study, we showed that low levels of oxidative stress trigger the release of TGFbeta, which subsequently activates TGase2 through the nuclear translocation of Smad3. Analysis of substrate proteins reveals that TGase2-mediated protein modification results in a decrease of protein solubility and a collapse of intermediate filament network, which leads to aggregation of proteins. We confirm these results using lens tissues from TGase2-deficient mice. Among several antioxidants tried, only N-acetylcysteine effectively inhibits TGFbeta-mediated activation of TGase2. These results indicate that TGFbeta mediates oxidative stress-induced protein aggregation through activation of TGase2 and suggest that the formation of protein aggregation may not be a passive process of self-assembly of oxidatively damaged proteins but may be an active cellular response to oxidative stress. Therefore, TGFbeta-TGase2 pathway may have implications for both the pathogenesis of age-related degenerative diseases and the development of pharmaceutics.</P>

First Case of ETV6–RUNX1 Fusion in Adult De Novo Acute Myeloid Leukemia Detected Using Targeted RNA Sequencing

Jeon Seong-Jun,Park Joo-Heon,Lim Ha Jin,Won Eun Jeong,Choi Hyun Woo,Choi Hyun Jung,Kee Seung Jung,Kim Soo Hyun,Shin Jong Hee,Shin Myung Geun 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.1