Candesartan과 Lercanidipine의 병용투여에 의한 혈압 하강 상승효과

한주희,이정진,김요한,명창선 충남대학교 약학대학 의약품개발연구소 2011 藥學論文集 Vol.26 No.-

국내 의료종사자에서 HHV-8의 항체양성률에 대한 연구

주우철,최용준,박재은,이혜명,이진수,정문현,김수미,문지혜 대한감염학회 2008 감염과 화학요법 Vol.40 No.4

HHV-8 virus is known to be associated with Kaposi's sarcoma (KS) in HIV seropositive patients and its seroprevalence has geographic difference, In South Korea, incidence of KS is low not only in general population but also in HIV patients compared to other countries, It is speculated that low seroprevalence of HHV-8 has contributed to the low incidence of KS in South Korea. We examined the seroprevalence of anti HHV-8 IgG of HIV seronegative health care workers in one University hospital. Enzyme-linked immunosorbent assay(ELISA) was used for diagnosis. One person (0.6% 1/164) was seropositive, six were equivocal (3.7%,6/164) and 157 people were seronegative (95.73%, 157/164). This study revealed that seroprevalence of HHV-8 in general population was. low in South Korea. Further studies are needed to be carried out to evaluate the low HHV-8 seroprevalence in Korea.

만성정신분열증 환자의 그림에 관한 현상학적 고찰 : 반복되는 주제를 중심으로

주명진 大韓神經精神醫學會 1979 신경정신의학 Vol.18 No.3

One frequently meets with the stereotypy in drawings during art therapy; the same motif is repeated several times in drawings. The author intended to reveal the characteristics of the stereotypy in this study. The subjects of the study include 12 chronic schizophrenics who revealed the stereotypy in their drawings. Control group include 20 chronic schizophrenics and non-schizophrenics who didn't show the stereotypy. The phenomenological characteristics of drawings of the study groups are as follows: 1. It showed more landscapes and still-lifes composed of plants and inanimate objects than the control groups, drawing. However, it revealed less human figures. 2. In terms of placement of the objects, it revealed more symmetricity than the control groups one. 3. It was composed of more cold colors than the contol groups' one. 4. In the structure of their drawings, it showed more baselines than the control groups' one. The characteristics of the study group compared with the control groups in views of clinical aspects are as follows: 1. Most of them were introvert in their premorbid personality. 2. Their ward activites and involvement to are therapy were passive in general.

척추 골다공증에서의 골절 위험 한계치

박진영,유문집,유석주,이성철,박희곤,김명호 대한골대사학회 1995 대한골대사학회지 Vol.2 No.2

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

흉요추부 골절의 수술적 치료

김명호,유문집,이성철,박진영,유석주,박희곤 단국대학교 1996 論文集 Vol.30 No.-

The purpose of operative treatment in thoracolumbar spine fractures is anatomical reduction and stabilization of the fractures and thus promote neurological recovery and early rehabilitation. To achieve these goals, complete preoperative assessment and recognition of the fracture pattern is necessary in addition to good surgical technique. The authors analyzed 27 cases of thoracolumbar spine fractures operated from Jun. 1994 to Dec.1995 at the Department of orthopaedic surgery, Dan-kook University Hospital. All cases were analysed according to McAfee classification. In deciding the appropriate surgical approach, fracture pat-tern, stability and neurologic status were considered. The result were as follows; 1. Unstable burst fracture, 11 cases, was the most frequent type. 2. 1st lumbar fracture was the most common level in this series. 3. Fall down, 15 cases out of 27, was the most common cause on thoracolumbar spine fracture. 4. Anterior approach was performed in 8 cases and posterior approach was performed in 19cases. 5. Good results were obtained through firm fixation and early rehabilitabion.

척추 수술시 자가혈액 수혈기를 이용한 자가수혈의 효과

김명호,유문집,유석주,박진영,정홍근,박희곤,문기혁 단국대학교 2000 論文集 Vol.35 No.-

Study Design : Spine fusion with fixation procedure is associated with substantial operative blood loss, which frequently necessitates transfusion. The authors evaluated the safety and efficacy of intraoperative autotransfusion using Cell Saver during spinal surgery. Summary of Literature Review : It has been reported that the contraindications to the use of intraoperative autologous transfusion are malignancy, infection, and gross wound contamination. Objectives : The purpose of this study was to evaluate the safety and efficacy of intraoperative autotransfusion using Cell Saver during spine surgery. Material and Methods : We retrospectively reviewed 62 patients who had operation for lumbosacral spinal stenosis and hypotensive anesthesia. Among them, Group Ⅰwhich received autotrans fusion using Cell Savers included 26 patients with fusion of 2 segments, and Group Ⅱ as control group included 13 patients. Group Ⅲ which received autotransfusion using Cell Savers included 17 patients with function of 3 segments, and Group Ⅳ as control group included 6 patients. We analyzed the amount of intraoperative blood salvage using a Cell Saver, the amount of total homologous transfusion amount, intraoperative blood loss, the amount of postoperative drainage amount and perioperative changes of hemoglobin, hematocrit and platelet count. Results : There was no statistical significance between Cell-Saver group and control group in amount of total homologous transfusion and intraoperative(except in 2 segment of fusion using cell saver: 86.5% increased) & postoperative blood loss(p>0.05). The circulatory balance(amount of intraoperative blood salvage using a Cell Saver plus amount of total homologous transfusion minus amount of total blood loss) was statistical significance between Cell-Saver group and Control group. The Cell-Saver group had positive balance and Control group had negative balance. There were no statistical differance in the evolusion of hemoglobin, hematoocrit and platelet count between Cell-Saver group and Control group(p>0.05). There was no transfusion reaction and thromboembolic disease in all group. Conclusion : In retrospective study, Cell Savers was safe and immediate availability in orthopedic surgery such as spinal surgery. It was effective methods for storing a sufficient volume of blood for spine surgery without affecting the patient's postoperative hemodynamic ststes, too. It was possible to operation without intraoperative homologous blood transfusion in 2 or 3 segment fusion. We may need further study.

都市 中心商業地域의 規制指針에 관한 硏究

김주현,이진욱,배혜진,하재명 대한건축학회 2003 대한건축학회논문집 Vol.19 No.3

The purpose of this study is to develop the control guidelines of central business district of city. In the first steps, the CBD is classified as five sub-districts; urban central commercial district, urban central service district, urban central resident district, urban central transportation district, and urban preservation district. And in the next step, to develop a new control guidelines according to each district character, we analyzed control guidelines of U.S.A and Japanese CBD which had several regulation system to control them in detail. The control guidelines of CBD can be subdivided into urban planning guidelines and urban design guidelines. The zoning regulation as urban planning guidelines is divided by density and use of CBD. Japanese and U.S.A special district planning and district planning as urban design guidelines are making practical application of several different regulation guidelines. Through these analyses, the organized factors of the control guidelines in CBD are arranged as follows; 1. Site guidelines about uses and pedestrian spaces, 2. Building guidelines about building locations, building scales, elevations, 3. Parking and loading guidelines, 4. Signs and lighting guidelines, 5. Landscaping guidelines.

何首烏 및 白首烏엑스가 흰쥐의 實驗的 高脂血症에 미치는 影響

丁明鉉,文永熙,李炳柱,鄭銀津 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1

This study was attempted to investigate the effect of Polygoni multiflori Radix and Cynanchi wilfordii Radix extract on the activities of S-GOT, S-GPT and level of total lipid, triglyceride. β-lipoprotein, phospholipid and total cholesterol in the serum of experimentally induced hyperlipermic rats, and on the effect of body, liver and spleen weight in rats. The results were shown as fouow; a) Polygoni multiflori Radix The activity of S-GOT was remarkably decreased, and activity of S-GPT was significantly decreased in all sample group, when compared with the control group(high lipid diet). The level of triglyceride and total cholesterol were remarkably decreased in all sample group, when compared with the control group. The level of total lipid and phospholipid were remarkably decreased on the 7 days after admistration of all sample group. The body weight of the rats decreased and the liver weight increased in control group were shown reduced as normal group on the administration of sample extract. b) Cynanchci wilfordii Radix The activities of S-GOT, S-GPT were remakably decreased in sample 100, 300㎎/㎏, when compared with the control group. The level of triglyceride and total cholesterol were remarkably decreased in sample 100, 300㎎/㎏. The level of phospholipid was significantly decreased in sample 100㎎/㎏. In sample treated group the death rate on the rats were 50 percentage in sample 500㎎/㎏. therefore in administration of sample 300, 500㎎/㎏ were very toxics. The body weight of the rats were remarkably decreased in all sample group, when compared with the normal and control group.