주의력결핍/과잉운동 장애(ADHD) 남자 아동들에서 Methylphenidate 치료 전후에 Tc-99m ECD SPECT로 측정된 국소 뇌혈류 이상과 인지적 특성변화와의 연관관계 : Statistical Parametric Mapping(SPM)과 전산화된 한국판 주의력 장애 진단 시스템(ADHD Diagnostic System, ADS)을 이용한 정량적 분석 Quantitative Analysis by Using Statistical Parametric Mapping(SPM) and ADHD Diagnostic System(ADS)

오은영,황이삭,문재석,조선미,윤석남,이명훈 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.2

Objective The purpose of this study was to examine the regional cerebral blood-flow (CBF) difference between boys with pure ACHD and normal controls before and after methylphenidate treatment, and also we examined the association between rCBF changes and cognitive characteristics of boys with pure ADHD before and after methylphenidate treatment. Methods The rCBF of 5 boys with pure AOHD and 5 control boys were examined by Tc-99m ECD brain SFECT and cognitive characteristics by ADS and every 5 ADHD boys took MPH for 12 to 16 weeks After that all ADHD boys took Tc-99m ECD brain SPECT and checked ADS again rCBF difference and changes before and after MPH treatment were quantified and analyzed by using SPM And associations between types of cognitive changes measured by ADS and rCBF changes were examined and quantitative associations between them were also analyzed by using Pearson's coefficient correlation. Results 1) Before MPH treatment, rCBF of ADHD boys were significantly decreased in left orbitofrontal area and left caudate nucleus compared to normal controls 2) After MPH treatment. rCBF of the same regions were significantly increased. 3) There was positive correlation between the degree of commission error(impulsivity disinhibition) among the ADS variables and the degree of blood-flow decrease in above two areas before MPH treatment but after MPH treatment, only with the degree of rC3F increase in Lt orbitofrontal area. Conclusion : These results suggest that the pathophysiology of impulsivity of disinhibition of the characteristic symploms of AOHD boys IS associated with hypoactivties of left orbibfrontal area and left caudate nucleus, and MPH pharmacodynamics in ADHD boys is associated to their actions on these two areas.

정신분열증 환자군에서 낮병원 치료가 경각심과 정신운동기능에 미치는 영향에 대한 예비 연구

오태성,김도훈,오병훈,현명호,유계준 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

Objectives : The aim of study is to compare the neuropsychological function changes between day hospital schizophrenic patients and out patient schizophrenic patients and to examine the effect of day hospital program on the cognitive function of schizophrenics. Methods : Neuropsychological test was done two times at discharge and 2 months later in 11 day hospital schizophrenic patients and 10 out patient schizophrenic patients by DSM-Ⅳ criteria. Vigilance, motor performance series are used as a computerized neuropsychological batteries. Results : Day hospital patients have significantly increased performance in some of motor performance series test items, but sustained attention have no tendency for increasing in day hospital patients. Conclusion : This results are preliminary. But this study suggest that psychomotor function of schizophrenics can be changed following day hospital treatment. And also we suggest that further day hospital treatment program expecially including congnitive rehabilitation needed.

스테로이드를 투여 받는 환자에서 발생한 Nocardia farcinica 뇌 종양 1예

심성훈,박혜인조,김충종,전재현,김의종,오명돈,김남중,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.5

Nocardiosis occurs mostly in the immunocompromised patients. N. farcinica is known to have resistance to some antibiotics and significant increase in morbidity and mortality in patients requiring long-term treatment. Nocardia farcinica infection, especially brain abscess, has not been reported in Korea. Here, we report a case of N. farcinica brain abscess in a patient receiving steroid treatment. The patient was a 64 year-old male with gouty arthritis, He received steroid for more than two months, because of allopurinol-hypersensitivity syndrome with skin rash. After three months of steroid therapy, he visited other hospital with mild fever and left thigh pain and was diagnosed of intramuscular abscess due to gram positive bacilli. One month later, he visited our hospital with right side weakness and was diagnosed as brain abscess. The causative organism turned out to be N. farcinica, which was confirmed by means of 16S rRNA sequencing. Antibiotics were selected by E-test results and treatment was successful.

가족성 고콜레스테롤혈증 유병자에서 HMG Co-A Reductasen Inhibitor 및 Bile Acid Resin의 투여로 인한 아킬레스건 황색종의 감소

채인호,한기훈,박영배,조주희,김효수,손대원,김철호,오병희,이명묵,최윤식,서정돈,이영우 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

접착제와 와동형성의 차이에 따른 5급 복합레진 수복의 전향적 임상연구

이경욱,정세준,한영철,손호현,엄정문,오명환,조병훈 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.4

본 연구의 목적은 복합레진을 이용한 비우식성 치경부 5급 병소 수복에 있어서, 3가지 다른 접착제를, 유지구를 부여한 치아와 부여하지 않은 치아에 적용하였을 때의 임상적인 효능의 차이를 비교하기 위함이다. 총 150개의 치아를 각각 25개씩 6개의 군으로 나누었다. A군 Scotchbond Multi-Purpose (SBMP, 3M ESPE, St, Paul, MN, USA, 4세대 접착제)를 사용하고 유지구를 부여하지 않음. B군: SBMP를 사용하고 유지구를 부여. C군: BC Plus (Vericom Co., Anyang, Gyeonggido, Korea, 5세대 접착제)를 사용하고 유지구를 부여하지 않음. D군: BC Plus를 사용하고 유지구를 부여. E군: Adper Prompt (3M ESPE, Seefeld, Germany, 6세대 접착제)를 사용하고 유지구를 부여하지 않음. F군: Adper Prompt를 사용하고 유지구를 부여. 모든 치아는 복합레진인 Denfil(Vericom Co., Anyang. Gyonggido. Korea)을 이용하여 충전하였다. 수복 직후와, 수복 6개월 후에 modified USPHS (United States Public Health Service) criteria에 따라 수복물을 임상적으로 평가하였다. 추가적으로 임상사진을 촬영하였으며, 에폭시 레진을 이용하여 복제한 후 주사전자현미경을 이용하여 이를 관찰하였다. 6개월 후 관찰 결과. alpha rating의 수가 각 실험군마다 동일하지는 않았지만, 통계적으로는 3가지의 접착제간에 유의할만한 차이는 없었고, 기계적인 유지구를 부여한 군과 부여하지 않은 군 간에도 유의할만한 차이는 없었다 (p > 0.05). 그러나 6개월의 관찰 기간은 일반적으로 기대되는 레진의 수명보다 짧기 때문에, 각 실험군 간의 차이를 알아보기 위해서는 추후 더 오랜 기간의 관찰이 요구된다. The purpose of this study is to evaluate prospectively the effect of different bonding systems and retention grooves on the clinical performance of resin restorations in non-carious cervical lesions (NCCLs). Thirty nine healthy adults who had at least 2 NCCLs in their promolar areas were included in this study. One hundred and fifty teeth were equally assigned to six groups; (A) Scotchbond Multi-Purpose (SBMP, 3M ESPE, St, Paul, MN, USA, 4th generation bonding system) without retention grooves; (B) SBMP with retention grooves: (C) BC Plus (Vericom Co., Anyang, Gyeonggido, Korea, 5th generation bonding system) without retention grooves; (D) BC Plus with retention grooves; (E) Adper Prompt (3M ESPE, Seefeld, Germany, 6th generation bonding system) without retention grooves: (F) Adper Prompt with retention grooves. All cavities were filled with a hybrid composite resin, Denfil (Vericom Co., Anyang, Gyeonggido, korea) by one operator. Restorations were evaluated at baseline and at 6-month recall, according to the modified USPHS (United states Public Health Service) criteria, Additionally, clinical photographs were taken and epoxy resin replicas were made for SEM evaluation. At 6-month recall, there were some differences in the number of alpha ratings among the experimental groups. But, despite the differences in the number of alpah ratings, there was no significant difference among the 3 adhesive systems (p > 0.05). There was also no significant difference between the groups with or without mechanical retention (p > 0.05). Follow-ups for longer periods than 6 months are needed to verify the clinical performance of different bonding systems and retention grooves. 〔J Kor Acad Cons Dent 31(4):300-311, 2006〕

Galvanic Replacement Reactions in Metal Oxide Nanocrystals

Oh, Myoung Hwan,Yu, Taekyung,Yu, Seung-Ho,Lim, Byungkwon,Ko, Kyung-Tae,Willinger, Marc-Georg,Seo, Dong-Hwa,Kim, Byung Hyo,Cho, Min Gee,Park, Jae-Hoon,Kang, Kisuk,Sung, Yung-Eun,Pinna, Nicola,Hyeon, Ta American Association for the Advancement of Scienc 2013 Science Vol.340 No.6135

<P><B>Hollowing Out Metal Oxide Nanoparticles</B></P><P>Corrosion is normally a problem, but it can be useful, for example, when you wish to create hollow metal nanoparticles, whereby the reduction of one metal species in solution drives the dissolution of the core of the particle. <B>Oh <I>et al.</I></B> (p. 964; see the Perspective by <B>Ibáñez and Cabot</B>) adapted this approach to metal oxide nanoparticles by placing Mn<SUB>3</SUB>O<SUB>4</SUB> nanocrystals in solution with Fe<SUP>2+</SUP> ions, which replaces the nanocrystal exterior with γ-Fe<SUB>2</SUB>O<SUB>3</SUB>. At sufficiently high Fe<SUP>2+</SUP> concentrations, hollow γ-Fe<SUB>2</SUB>O<SUB>3</SUB> nanocages formed. These hollow structures could be used as anode materials for lithium ion batteries.</P>

Lessons learned from 100 initial cases of laparoscopic liver surgery

Young Hoon Kim,Young Hoon Roh,Sung Yong Oh,Jin Han Cho,Jong Hoon Lee,Sung Wook Lee,Myoung Hwan Roh,Jin Sook Jeong,Sang Young Han,Ghap Joong Jung 대한외과학회 2010 대한외과학회 학술대회 초록집 Vol.2010 No.11

정신분열병 치료효과에 대한 신경인지기능의 예측력에 관한 연구

오병훈,이희상,최의헌,현명호,조현상,유계준 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.6

연구목적 : 신경인지기능검사가·정신분열 병 환자의 혜후 및 치료에 대한 반응을 예측할 수 있는 인자로 작용할 수 있다는 연구결과들이 있었다. 이들 연구에서는 인지기능을 측정하는 검사도구 중 일부를 이용하여 치료 결과를 예측해 본 것이므로 저자들은 보다 광범위한 신경인지기능검사를 이용하여 이들 중 어떤 검사결과가 정신분열 병 환자들에 대한 치료결과를 얼마나 예측해 줄 수 있는지를 알아보기 위해 본 연구를 수행하였다. 방법: 연구대상은 BSM-IV 진단기준에 의거 정 신분열병으로 진단된 입원 환자 33명을 대상으로 최소 1주일 이상의 약물세척 후 약물투여 직전에 K-WAIS. WMS-R Vienna Test System 중 Signal Detection,Decision-Reaction Timer. Motor Performance Series 등의 신경인지기능검사를 시행하였다. 치료에 대한 반응의 평가는 Brief Psychatric Rating Scale(BPRS)와 Clinical Global Impression(CGI)을 사용하여 약물투여 전과 약물투여 후 8주에 시행하였다. 연구대상을 약물투여후 8주째의 BPRS점수가 약물투여 전의 BPRS 점수에 비해 20% 이상 호전이 있으면서 CGl 점수가 3이하인 경우를 기준으로 호전군과 비호전군으로 나눈 다음 두 군 사이의 신경인지기능검사 결과를 비교해보았다. 결 과: 신경인지기능정사에서 K-WAIS 중 언어성지능, 전체지능 Vienna Teat System 중 신호탐지력검사의 정확한 반응수, 반응 결정시간검사의 정확한 반응수 등에서 호전군과 비호전군 사이에 통계적으로 유의한 차이가 있었다. 이들 변인을 가지고 호전군과 비호전군을 구분하는 판별분석을 시행한 결과 66.7%의 환자를 정확하게 핀별하여 주었으나 통계적으로 유의하지는 않은 것으로 나타났다. 결론 : 판별 분석에 의하여 신경인지기능검사로써 환자군을 호전군과 비호전군으로 구분한 결과는 통계적으로 유의한 수준은 아니었으나, 신경인지기능검사가 정신분열병의 치료결과를 예측할수 있는 인자로 활용 될 가능성이 있음을 시사 한다. Objectives : This study was to investigate a wider range of neurocognitive function tests to find out how accurately each subtest could predict the outcomes of treatment in schizophrenics. Methods : The subjects were 33 inpatients diagnosed as schizophrenia according to DSM-IV. Each subject had a drug wash-out period of at least 1 week and had been given K-WAIS, WMS-R, and Signal Detection, Derision Reaction Timer, and Motor Performance Series in Vienna Test System just before drug administration. Treatment response was evaluated with BPRS and CGI scales before and 8 weeks artier drug treatment. We divided the subjects into responders and non-responders according to the outcomes of the above clinical scales in week 8. The responder group was defined with having 20% increase in BPRS score and a CGI score of less than 3.Then we compared the neuropsychological test results between the two groups. Results : Significantly different results between responders and non-responders were Verbal IQ and Full Scale IQ in K-WAIS, the number of correct responses in Signal Detection and Decision Reaction Timer in Vienna Test System. In discrimination analysis of the two groups using these subtests as variables, we could predict the responders with 66.7% accuracy, even though statistically non-significant. Conclusion : Although discriminating between responders and non-responders using negro-cognitive function tests were proven to be statistically non-significant, the possibility that neurocognitive function tests can be utilized to predict the treatment outcome in schizophrenia cannot be completely ruled out.

Neoadjuvant chemoradiotherapy affects the indications for lateral pelvic node dissection in mid/low rectal cancer with clinically suspected lateral node involvement: a multicenter retrospective cohort study.

Oh, Heung-Kwon,Kang, Sung-Bum,Lee, Sung-Min,Lee, Soo Young,Ihn, Myoung Hun,Kim, Duck-Woo,Park, Ji Hoon,Kim, Young Hoon,Lee, Kyung Ho,Kim, Jae-Sung,Kim, Jin Won,Kim, Jee Hyun,Chang, Tae-Young,Park, Sun Raven Press 2014 Annals of Surgical Oncology Vol.21 No.7

<P>Although lateral pelvic node dissection (LPND) is recommended for rectal cancer with clinically metastatic lateral pelvic lymph nodes (LPNs), LPNs may respond to neoadjuvant chemoradiotherapy (nCRT). Our aim was to determine the optimal indication for LPND after nCRT for mid/low rectal cancer.</P>

Lipid production in <i>Porphyridium cruentum</i> grown under different culture conditions

Oh, Sung Ho,Han, Jae Gun,Kim, Young,Ha, Ji Hye,Kim, Seung Seop,Jeong, Myoung Hoon,Jeong, Hyang Suk,Kim, Na Young,Cho, Jeong Sub,Yoon, Won Byong,Lee, Shin Young,Kang, Do Hyung,Lee, Hyeon Yong Elsevier 2009 Journal of bioscience and bioengineering Vol.108 No.5

<P><B>Abstract</B></P><P>Autotrophic growth of <I>Porphyridium cruentum</I> under 18:12?h and 12:12?h light:dark cycles showed the maximum cell concentration of 2.1?g-dry wt./L, whereas the specific growth rate, 0.042 (1/h), at 18:6?h is faster than that of 12:12?h, 0.031 (1/h), respectively. The highest lipid accumulation level, 19.3 (%, w/w), was achieved at 12:12?h cycle. Under dark cultivation condition with 10?g/L of glucose, the lipid accumulation in the cell was 10.9 (%, w/w), whereas the heterotrophic growth with glycerol as the carbon resource showed low level of cell concentration and lipid production, compared to that of glucose. The glucose was decided to be a suitable carbon resource for the heterotrophic growth of <I>P. cruentum</I>. The lipids from <I>P. cruentum</I> seemed be feasible for biodiesel production, because over 30% of the lipid was C<SUB>16</SUB>–C<SUB>18:1</SUB>. The cultivation time and temperature were important factors to increase the maximum cell concentration. Extending the cultivation time helps maintain the maximum cell concentration, and higher lipid accumulation was achieved at 25?°C, compared to 35?°C. The fed-batch cultures showed that, under the light condition, the specific production rate was slightly decreased to 0.4% lipid/g-dry wt./day at the later stage, whereas, under the dark condition, the specific production rate was maintained to be a maximum value of 1.1% lipid/g-dry wt./day, even in the later stage of cultivation. The results indicate that the heterotrophic or 12:12?h cyclic mixotrophic growth of <I>P. cruentum</I> could be used for the production of biodiesel in long-term fed-batch cultivation of <I>P. cruentum</I>.</P>