Early Detection and Gemcitabine/Cisplatin Combination Positively Effect Survival in Sarcomatoid Carcinoma of the Urinary Bladder

Baseskioglu, Barbaros,Duman, Berna Bozkurt,Kara, I. Oguz,Can, Cavit,Yildirim, Mustafa,Acikalin, Mustafa Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Background and Objectives: This study aimed to present the clinicopathological characteristics and treatment of patients with bladder carcinoma with sarcomatoid differentiation at our institution. Methods: Between 1995-2009, 950 patients were followed-up for bladder carcinoma. Among them, 14 patients with sarcomatoid carcinoma were retrospectively reviewed, and their clinical, pathological features and treatment were recorded. Results: Median age of the patients was 65 years (range: 41-86 years), 12 (86%) being male and 2 (14%) female. All the patients presented with hematuria and 11 (88%) had a history of smoking. The tumor growth pattern was solid in 10 patients, papillary in 2, and mixed in 2. In all, 5 of the patients had urothelial carcinoma with sarcomatoid differentiation and 9 were diagnosed with sarcomatoid carcinoma. Five patients underwent radical cystectomy with ileal conduit surgery, 2 patients refused cystectomy, and 8 patients underwent re-TUR. Following diagnosis, 12 of the patients died in mean 10.7 months (range: 1-48 months). Conclusion: Urothelial carcinomas with sarcomatoid features are aggressive and are usually at advanced stage at the time of diagnosis. The outcomes of multimodal treatment are not satisfactory. Significant findings of the present study are that early diagnosis positively affect survival and that gemcitabine and cisplatin in combination can positively affect survival.

Simultaneous Sulfide and Nitrite Removal from Industrial Wastewaters under Denitrifying Conditions

Esra Can Dogan,Mustafa Türker,Levent Dagasan,Ayla Arslan 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.3

Bio-oxidation of sulfide under denitrifying conditions is a key process in the treatment of gas and liquids that are contaminated with sulfide and nitrite. A lab-scale continuous flow stirred tank reactor (CFSTR)was operated with nitrite as the electron acceptor for the evaluation of the effects of loading rates, hydraulic retention time (HRT) and substrate concentrations on the performance of the autotrophic denitrification process. The influent sulfide concentration was maintained at 0.16 kg/m3and the HRT was decreased from 8.4 to 2 h and for the entire study period, the sulfide removal efficiency was above 80% for the loading rates that ranged from 0.47 to 2.16 kg S-2/m3day. However, lower influent loading of NO2--N that correspond to the stoichiometric ratios was used and the nitrite removal efficiency was close to 100%. The stoichiometry of sulfide oxidation was calculated by assuming the different end-products based on thermodynamic approach. We compared the calculated values with experimental yield values. Bio-oxidation of sulfide under denitrifying conditions is a key process in the treatment of gas and liquids that are contaminated with sulfide and nitrite. A lab-scale continuous flow stirred tank reactor (CFSTR)was operated with nitrite as the electron acceptor for the evaluation of the effects of loading rates, hydraulic retention time (HRT) and substrate concentrations on the performance of the autotrophic denitrification process. The influent sulfide concentration was maintained at 0.16 kg/m3and the HRT was decreased from 8.4 to 2 h and for the entire study period, the sulfide removal efficiency was above 80% for the loading rates that ranged from 0.47 to 2.16 kg S-2/m3day. However, lower influent loading of NO2--N that correspond to the stoichiometric ratios was used and the nitrite removal efficiency was close to 100%. The stoichiometry of sulfide oxidation was calculated by assuming the different end-products based on thermodynamic approach. We compared the calculated values with experimental yield values.

Standardized Uptake Values Highly Correlate with Tumor Size and Fuhrman Grade in Patients with Clear Cell Renal Cell Carcinoma

Polat, Emre Can,Otunctemur, Alper,Ozbek, Emin,Besiroglu, Huseyin,Dursun, Murat,Ozer, Kutan,Horsanali, Mustafa Ozan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Background: We investigated the correlation between standardized uptake value (SUVmax), tumor size and Fuhrman grade in patients with renal cell carcinoma (RC). Materials and Methods: We retrospectively analyzed the data of 54 patients with clear cell renal cell carcinoma histopathologically diagnosed who underwent fluorine-18 fluoro-2 deoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) between January 2005 and March 2014. Results: Avarage tumor sizes were $5.64{\pm}1.85$, $6.85{\pm}2.24$ and $7.98{\pm}2.45$ in low, medium and high SUVmax groups, respectively. The Spearman's correlation coefficient between the tumor size and SUVmax was 0.385 (p=0.004) and between the Fuhrman grade and SUVmax was 0.578 (p<0.001). Conclusions: SUVmax appears highly correlated with tumor size and Fuhrman grade in patients with histopathologically confirmed clear cell RC. Multicenter studies are needed to provide larger series for more accurate results.

Methamphetamine Use Disorder and Inflammation: A Case-Control Study

Nilifer Gürbüzer,Mustafa Can Güler,ibrahim Hakkı Tör 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.5

Objective : Methamphetamine use disorder (MUD) is a global health condition that impairs a person’s health which may result in mor-bidity and mortality. Inflammation is a crucial process playing a vital role in MUD. For this reason, it is necessary to examine biochemi-cal parameters for follow-up and treatment alternatives. Methods : We aimed to reveal the relationship between inflammatory response and MUD by evaluating peripheral hemogram parame-ters, leukocyte count, subtypes, and their ratios to each other, systemic immune inflammation index (SII), monocyte/high-density lipo-protein (HDL) ratio, and human C-reactive protein (CRP) in adult men with MUD. We included 76 adult male participants in the pa-tient group and 70 adult male participants in the control group. We calculated the neutrophil/lymphocyte rate (NLR), monocyte/lymphocyte rate (MLR), platelet/lymphocyte rate (PLR), and basophil/lymphocyte rate (BLR). In addition, we obtained the SII and the monocyte/HDL rate. Results : The patients’ leukocyte (p<0.001), platelet (p<0.001), plateletcrit (PCT) (p=0.002), neutrophil (p<0.001), monocyte (p=0.002), CRP (p<0.001), NLR (p=0.001), PLR (p=0.004), MLR (p=0.009), SII (p<0.001) and monocyte/HDL ratio (p<0.001) were higher than the control group. We observed a significant and positive relationship between the daily methamphetamine intake, and methamphetamine use duration (p=0.002), PCT (p=0.044), neutrophil (p=0.021), NLR (p=0.001), PLR (p=0.004), MLR (p=0.029), and SII (p<0.001). Daily methamphetamine intake had a significant and positive effect on SII. A one-unit increase in daily methamphetamine intake elevated SII by 165.53 units. Conclusion : The results confirm the presence of peripheral subclinical inflammation and systemic immune inflammation in adult men with MUD.

Corrosion and Wear Characteristics of Electroless Ni–P, Ni–P–W and Composite Ni–P–W/Al2O3 Coatings on AZ91 Sheet

Selim Taşci,Reşat Can Özden,Mustafa Anik 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.2

Electroless Ni–P–W was coated on AZ91 sheets with various W contents and both the corrosion and wear resistance characteristicsof these coatings were observed. The increase in W content resulted in a decrease in P content and an increase inthe crystallinity of the electroless coatings. The corrosion resistance of the electroless coatings increased upon increase inW content of the electroless coatings up to approximately 5%. Above this content, however, the corrosion resistance tendedto decrease due to the disturbed grain structure of the electroless coating. But both the surface hardness and wear resistanceincreased concurrently due to the positive contribution of W solid solution hardening. The applied heat treatment resulted ina decrease in the corrosion resistance due to the disappearance of the amorphous structure and increase in both the surfacehardness and wear resistance due to the precipitation hardening. Al2O3dispersion was better with the nonionic surfactant,as compared to the anionic and cationic surfactants. Composite coating reduced the corrosion resistance and increased thewear resistance of the electroless Ni–P–W coatings. The applied heat treatment was observed to have positive contributionto Ni–P–W coatings in getting the optimum corrosion and wear resistance combination.

Efficacy of magnetic resonance imaging for diagnosis of penile fracture: A controlled study

Erkin Saglam,Fatih Tarhan,Mustafa B. Hamarat,Utku Can,Alper Coskun,Emre Camur,Kemal Sarica 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.4

Purpose: To evaluate the diagnostic value of magnetic resonance imaging (MRI) in patients with suspected penile fracture. Materials and Methods: A total of 122 patients admitted to our inpatient clinic with a suspicion of penile fracture following a recent history of penile trauma and who underwent surgical exploration were included this study. A thorough physical examination, a detailed medical history, description of the trauma, and preoperative International Index of Erectile Function (IIEF) scores were obtained for each patient prior to surgery. Thirty-eight of these patients were evaluated with MRI before the surgical exploration. Intraoperative findings were also recorded. Physical findings and IIEF scores were also recorded at postoperative 6 months. Results: The mean age of our patient group was 36.5±12.3 years. Penile fracture was detected in 105 of 122 patients in whom surgical exploration was performed owing to a suspected diagnosis. The mean time interval from penile trauma to hospital admittance was 9.9±15.1 hours. No cavernosal defect was detected in 9 of 84 patients (10.7%) who were not evaluated with MRI prior to surgery. Compared with surgical exploration, MRI findings showed 100% (30 of 30) sensitivity and 87.5% (7 of 8) specificity in the diagnosis of penile fracture. MRI had a high negative predictive value of 100% (7 of 7) and a positive predictive value of 96.7% (30 of 31) with just 1 misdiagnosed patient. Conclusions: MRI is a reliable diagnostic tool in the diagnosis of penile fractures. Compared to history and physical findings taken all together, the high sensitivity and specificity of this imaging technique can decrease the number of unnecessary surgical explorations.

Synthesis, characterization and photovoltaic properties of novel molecules based on triarylamine dyes

Sule Erten-Ela,Magdalena Marszalek,Serpil Tekoglu,Mustafa Can,Siddik Icli 한국물리학회 2010 Current Applied Physics Vol.10 No.3

We report the synthesis, electrochemical and photovoltaic properties of triphenylamine based novel organic sensitizer, comprising donor, electron-conducting and anchoring group. Different triphenylamines were synthesized as donor unit and connected to cyano-acidic acid acceptor over vinyl group. In this work, we studied on two novel dyes (TPA2, TPA3) by attaching methyl to m-position and diphenylamine to p-position of the basic triphenylamine structure, respectively. All derivatives absorb at visible region of solar spectrum in the range of 350–632 nm. By introducing strong electron injection groups to triphenylamine ring, band gap becomes narrower while EHOMO–ELUMO levels are tuned. All current voltage (I–V)measurements were done under 100 mW/㎠ light intensity and AM 1.5 conditions. TPA3 chromophore with the lowest band gap shows the best cell performance with an efficiency (η) of 4.12%, a short-circuit photocurrent density (Isc) of 8.07 mA/㎠, an open-circuit voltage (Voc) of 714 mV and a fill factor (FF) of 0.72.

Unroofed Coronary Sinus Atrial Septal Defect Misdiagnosed as Ostium Primum Defect

Semi Ozturk,Gunduz Durmus,Muhsin Kalyoncuoglu,Mustafa Sari,Ozlem Ozbek,Mehmet Can 대한심장학회 2018 Korean Circulation Journal Vol.48 No.1

Cisplatin Plus Gemcitabine for Treatment of Breast Cancer Patients with Brain Metastases: a Preferential Option for Triple Negative Patients?

Erten, Cigdem,Demir, Lutfiye,Somali, Isil,Alacacioglu, Ahmet,Kucukzeybek, Yuksel,Akyol, Murat,Can, Alper,Dirican, Ahmet,Bayoglu, Vedat,Tarhan, Mustafa Oktay Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Background: To assess the efficacy and tolerability of Cisplatin plus Gemcitabine combination in patients with brain metastases (BM) from breast cancer (BC). Materials and Methods: Eighteen BC patients with BM who were treated with Cisplatin plus Gemcitabine regimen between 2003-2011 were evaluated. Results: A median of 6 cycles of this regimen were received, in fifteen patients (83.3%) as first-line chemotherapy, in 2 as second-line and in 1 as third-line after diagnosis of BM. Dose reduction was performed in 11 (61.1%) patients; major reasons were neutropenia and leukopenia. Grade III neutropenia and Grade II trombocytopenia rates were 33.3% and 16.7% respectively. Overall response rate (ORR; complete+partial response rate) was 33.4% (n=6) for the entire study population; triple negative patients achieved an 66.6% ORR while hormone receptor (HR) positive patients had 25% and HER2 positive patients 12.5%. Median progression-free survival was 5.6 months (2.4-8.8 months, 95%CI) and longer in patients with triple negative breast cancer (TNBC) (median 7.4 months, 95%CI, 2.4-12.3 months) than the patients with other subtypes (median 5 months for HER2 positive and 3.6 months for HR positive patients). Median PFS of the patients with TNBC who received this regimen as first-line was 9.2 months (5.2-13.2 months, 95%CI). Conclusions: Cisplatin plus Gemcitabine may be a treatment option for patients with BM from breast cancer. Longer PFS and higher response rates are results that support the usage of this regimen especially for the triple negative subtype. However, further prospective and randomized trials are clearly required to provide more exact information.

Second-Line Irinotecan after Cisplatin, Fluoropyrimidin and Docetaxel for Chemotherapy of Metastatic Gastric Cancer

Kucukzeybek, Yuksel,Dirican, Ahmet,Erten, Cigdem,Somali, Isil,Can, Alper,Demir, Lutfiye,Bayoglu, Ibrahim Vedat,Akyol, Murat,Medeni, Murat,Tarhan, Mustafa Oktay Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Aim: Tumors of upper gastrointestinal tract are among the cancers that have a quite lethal course. Cytotoxic chemotherapy is the most efficient therapeutic modality for metastatic gastric cancer. In patients who do not respond to first-line treatment, the response rate to second-line therapies is generally low and the toxicity rates high. This study concerned the efficacy and the side effect profile of second-line therapy with irinotecan in the patients who were being followed-up with the diagnosis of metastatic gastric cancer in $\dot{I}$zmir, Turkey. Materials and Methods: We retrospectively evaluated the efficacy and toxicity in 31 patients with metastatic gastric adenocarcinoma who presented to the polyclinic of Medical Oncology of Izmir Ataturk Education and Research Hospital between May 2008 and July 2011. All received chemotherapy regimens containing cisplatin, fluoropyrimidine (5-FU) and docetaxel as the first-line therapy for late stage disease. Irinotecan as a single agent was given at a dose of 210 mg/$m^2$ on each 21 days. Irinotecan (180 mg/$m^2$ on day 1), 5-FU (500 mg/$m^2$ on days 1-2) and leucovorin (LV; 60 mg/$m^2$ on days 1-2) as a combined regimen were given over a 14 day period. Results: Median age was 54 (range, 31-70). Irinotecan was given as a combined regimen for median 6 cycles (range, 3-12) and as a single agent for median 3 cycles (range, 1-10). Metastases were detected in one site in six patients (19%), in two different sites in 17 patients (55%) and in three or more sites in eight patients (26%). Four patients (12.9%) showed partial response and six patients (19.3%) showed stable disease. Progression-free survival (PFS) was found to be 3.26 months (95% CI, 2.3-4.2). Median overall survival (OS) was found to be 8.76 months (95% CI, 4.5-12.9). The most commonly seen grade 3/4 side effect was neutropenia but the the therapy was generally well-tolerated. Conclusions: In this study, it was demonstrated that second-line therapy with irinotecan given following the first-line therapy with cisplatin, fluoropyrimidine (5-FU) and docetaxel was efficient and safe. Further studies are needed for confirmation.