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      • Formal Verification of Twin Clutch Gear Control System

        Muhammad Zaman,Amina Mahmood,Muhammad Atif,Muhammad Adnan Hashmi,Muhammad Kashif,Mudassar Naseer International Journal of Computer ScienceNetwork S 2024 International journal of computer science and netw Vol.24 No.3

        Twin clutch model enables the power-shifts as conventional planetary automatic transmission and eradicates the disadvantages of single clutch trans- mission. The automatic control of the dual clutches is a problem. Particularly to control the clutching component that engages when running in one direction of revolution and disengages when running the other direction, which exchange the torque smoothly during torque phase of the gearshifts on planetary-type automatic transmissions, seemed for quite a while hard to compensate through clutch control. Another problem is to skip gears during multiple gearshifts. However, the twin clutch gear control described in ["M Goetz, M C Levesley and D A Crolla. Dynamics and control of gearshifts on twin clutch transmissions, Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering 2005"], a significant improvement in twin clutch gear control system is discussed. In this research our objective is to formally specify the twin clutch gear control system and verify it with the help of formal methods. Formal methods have a high potential to give correctness estimating techniques. We use UPPAAL for formal specification and verification. Our results show that the twin clutch gear control model partially fulfills its functional requirements.

      • Formal Analysis of Distributed Shared Memory Algorithms

        Muhammad Atif,Muhammad Adnan Hashmi,Mudassar Naseer,Ahmad Salman Khan International Journal of Computer ScienceNetwork S 2024 International journal of computer science and netw Vol.24 No.4

        The memory coherence problem occurs while mapping shared virtual memory in a loosely coupled multiprocessors setup. Memory is considered coherent if a read operation provides same data written in the last write operation. The problem is addressed in the literature using different algorithms. The big question is on the correctness of such a distributed algorithm. Formal verification is the principal term for a group of techniques that routinely use an analysis that is established on mathematical transformations to conclude the rightness of hardware or software behavior in divergence to dynamic verification techniques. This paper uses UPPAAL model checker to model the dynamic distributed algorithm for shared virtual memory given by K.Li and P.Hudak. We analyse the mechanism to keep the coherence of memory in every read and write operation by using a dynamic distributed algorithm. Our results show that the dynamic distributed algorithm for shared virtual memory partially fulfils its functional requirements.

      • Ki67 Index in Breast Cancer: Correlation with Other Prognostic Markers and Potential in Pakistani Patients

        Haroon, Saroona,Hashmi, Atif Ali,Khurshid, Amna,Kanpurwala, Muhammad Adnan,Mujtuba, Shafaq,Malik, Babar,Faridi, Naveen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

        Introduction: Breast cancer aggressiveness can be correlated with proliferation status of tumor cells, which can be ascertained with tumor grade and Ki67 indexing. However due to lack of reproducibility, the ASCO do not recommend routine use of Ki67 in determining prognosis in newly diagnosed breast cancers. We therefore aimed to determine associations of the Ki67 index with other prognostic markers like tumor size, grade, lymph node metastasis, ER, PR and HER2neu status. Methods: A total of 194 cases of newly diagnosed breast cancer were included in the study. Immunohistochemical staining for ER, PR, HER2neu and Ki67 was performed by the DAKO envision method. Associations of the Ki67 index with other prognostic factors were evaluated both as continuous and categorical variables. Results: Mean age of the patients was 51.7 years (24-90). Mean Ki67 index was 26.9% (1-90). ER, PR, HER2neu positivity was noted in 90/194 cases (46.4%), 74/194 cases (38.1%) and 110/194 cases (56.70%) respectively. Significant association was found between Ki67 and tumor grade, PR, HER2neu positivity and lymph node status, but no link was apparent with ER positivity and tumor size. There wasan inverse relation between Ki67 index and PR positivity, whereas a direct correlation was seen with HER2neu positivity. However, high Ki67 (>30%) was associated with decreased HER2neu positivity as compared to intermediate Ki67 (16-30%). The same trend was established with lymph node metastasis. Conclusion: Our study indicates that with high grade tumors, clinical utility of ki67 is greater in combination with other prognostic markers because we found that tumors with Ki67 higher than 30% have better prognostic profile compared to tumors with intermediate Ki67 level, as reflected by slightly lower frequency of lymph node metastasis and HER2neu expression. Therefore we suggest that Ki67 index should be categorized into high, intermediate and low groups when considering adjuvant chemotherapy and prognostic stratification.

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