Risk factor analysis of coexisting endometrial carcinoma in patients with endometrial hyperplasia: a retrospective observational study of Taiwanese Gynecologic Oncology Group

Yu-Li Chen,Kung-Liahng Wang,Min-Yu Chen,Mu-Hsien Yu,Chen-Hsuan Wu,Yu-Min Ke,Yi-Jen Chen,Yin-Yi Chang,Keng-Fu Hsu,Ming-Shyen Yen 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.1

Objective: To evaluate the clinical outcome and parameters related to coexisting endometrial carcinoma in women with tissuediagnosed endometrial hyperplasia. Methods: Between January 1991 and December 2009, three hundred and eighty-six patients with the presumptive diagnosis of endometrial hyperplasia were retrieved. Among these, one hundred and twenty-five patients were identified as having coexisting endometrial carcinoma in hysterectomy specimens. The three hundred and eighty-six patients were divided into two groups: the hyperplasia-benign group (261 cases) and the hyperplasia-malignant group (125 cases). Several clinical parameters including age, menopausal status, history of abnormal uterine bleeding, obstetrical history, medical history of diabetes and hypertension, BMI, and preoperative pathologic results were investigated. Results: Age ≥53 (odds ratio [OR], 2.40; 95% confidence interval [CI], 1.26 to 4.57), menopausal status (OR, 2.07; 95% CI, 1.14to 3.76), diabetes history (OR, 7.33; 95% CI, 2.79 to 19.26), abnormal uterine bleeding (OR, 3.99; 95% CI, 1.22 to 13.02), atypical endometrial hyperplasia (OR, 7.38; 95% CI, 4.03 to 13.49), and body mass index ≥27 (OR, 3.24; 95% CI, 1.76 to 5.97) were independent risk factors for prediction of endometrial hyperplasia coexisting with endometrial carcinoma. The diagnostic efficacy of atypical endometrial hyperplasia to predict the endometrial hyperplasia coexisting with endometrial carcinoma was better than or similar to those of other independent factors and combinations of these factors. Conclusion: Coexisting malignancy should be considered when examining endometrial hyperplasia patients with the related risk factors, especially atypical endometrial hyperplasia.

Correlation between Non-Alcoholic Fatty Liver Disease and Visceral Adipose Tissue in Non-Obese Chinese Adults: A CT Evaluation

Ai-Hong Yu,Yang-Yang Duan-Mu,Yong Zhang,Ling Wang,Zhe Guo,Yong-Qiang Yu,Yu-Sheng Wang,Xiao-Guang Cheng 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.5

Objective: To investigate the correlation between non-alcoholic fatty liver disease and visceral adipose tissue in non-obese Chinese adults using computed tomography (CT). Materials and Methods: The study included 454 subjects undergoing abdominal CT scan. Degree of CT attenuation in liver and spleen, and the degree of fat infiltration in liver were evaluated according to three indices: the attenuation value of liver parenchyma (CTLP), the attenuation ratio of liver and spleen (LSratio) and the attenuation difference between liver and spleen (LSdif). Visceral fat area (VFA) and total fat area (TFA) at L2/3 and L4/5 levels were measured, and the abdominal subcutaneous fat area (SFA) was calculated. Bivariate correlation analysis was carried out to determine the correlation among these factors. Results: In men, VFA, SFA and TFA at L2/3 and L4/5 levels showed significant differences in terms of the three indices to distinguish fatty liver from non-fatty liver (all, p < 0.001). In men, all the three indices showed negative correlation with TFA, SFA and VFA (all, p < 0.001). The negative correlation between the three indices and VFA at the L2/3 level was higher than at L4/5 level (r = -0.476 vs. r = -0.340 for CTLP, r = -0.502 vs. r = -0.413 for LSratio, r = -0.543 vs. r = -0.422 for LSdif, p < 0.001, respectively). The negative correlation between LSratio, LSdif and VFA at L2/3 and L4/5 levels was higher than SFA at the corresponding level. In women, all the three indices showed negative correlation with VFA and TFA at L2/3 and L4/5 levels, and the negative correlation between CTLP and VFA was higher at L2/3 level than at L4/5 level (r = -0.294 vs. r = -0.254, p < 0.001). Conclusion: In non-obese Chinese adults, the degree of hepatic fatty infiltration showed a strong correlation with abdominal fat on CT. VFA at L2/3 level was more closely related to fatty liver compared with VFA at L4/5 level.

The feasibility of detecting endometrial and ovarian cancer using DNA methylation biomarkers in cervical scrapings

Cheng-Chang Chang,Hui-Chen Wang,Yu-Ping Liao,Yu-Chih Chen,Yu-Chun Weng,Mu-Hsien Yu,Hung-Cheng Lai 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.1

Objective: We hypothesized that DNA methylation of development-related genes may occur in endometrial cancer (EC)/ovarian cancer (OC) and may be detected in cervical scrapings. Methods: We tested methylation status by quantitative methylation-specific polymerase chain reaction for 14 genes in DNA pools of endometrial and OC tissues. Tissues of EC/normal endometrium, OC/normal ovary, were verified in training set using cervical scrapings of 10 EC/10 OC patients and 10 controls, and further validated in the testing set using independent cervical scrapings in 30 EC/30 OC patients and 30 controls. We generated cutoff values of methylation index (M-index) from cervical scrapings to distinguish between cancer patients and control. Sensitivity/specificity of DNA methylation biomarkers in detecting EC and OC was calculated. Results: Of 14 genes, 4 (PTGDR, HS3ST2, POU4F3, MAGI2) showed hypermethylation in EC and OC tissues, and were verified in training set. POU4F3 and MAGI2 exhibited hypermethylation in training set were validated in independent cases. The mean M-index of POU4F3 is 78.28 in EC and 20.36 in OC, which are higher than that in controls (6.59; p<0.001 and p=0.100, respectively), and that of MAGI2 is 246.0 in EC and 12.2 in OC, which is significantly higher that than in controls (2.85; p<0.001 and p=0.480, respectively). Sensitivity and specificity of POU4F3/MAGI2 were 83%–90% and 69%–75% for detection of EC, and 61% and 62%–69% for the detection of OC. Conclusion: The findings demonstrate the potential of EC/OC detection through testing for DNA methylation in cervical scrapings.

Pristimerin Inhibits Breast Cancer Cell Migration by Up-regulating Regulator of G Protein Signaling 4 Expression

Mu, Xian-Min,Shi, Wei,Sun, Li-Xin,Li, Han,Wang, Yu-Rong,Jiang, Zhen-Zhou,Zhang, Lu-Yong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Background/Aim: Pristimerin isolated from Celastrus and Maytenus spp can inhibit proteasome activity. However, whether pristimerin can modulate cancer metastasis is unknown. Methods: The impacts of pristimerin on the purified and intracellular chymotrypsin proteasomal activity, the levels of regulator of G protein signaling 4 (RGS 4) expression and breast cancer cell lamellipodia formation, and the migration and invasion were determined by enzymatic, Western blot, immunofluorescent, and transwell assays, respectively. Results: We found that pristimerin inhibited human chymotrypsin proteasomal activity in MDA-MB-231 cells in a dose-dependent manner. Pristimerin also inhibited breast cancer cell lamellipodia formation, migration, and invasion in vitro by up-regulating RGS4 expression. Thus, knockdown of RGS4 attenuated pristimerin-mediated inhibition of breast cancer cell migration and invasion. Furthermore, pristimerin inhibited growth and invasion of implanted breast tumors in mice. Conclusion: Pristmerin inhibits proteasomal activity and increases the levels of RGS4, inhibiting the migration and invasion of breast cancer cells.

HIF1α promotes prostate cancer progression by increasing ATG5 expression

Kaiyuan Yu,Luxia Xiang,Shaoxun Li,Shuaibin Wang,Chaohao Chen,Haiqi Mu 한국통합생물학회 2019 Animal cells and systems Vol.23 No.5

Prostate cancer (PCa) is the most frequently diagnosed cancer among men. However, the major modifiable risk factors for PCa are poorly known and its specific mechanism of progression remains unclear. Here we reported that, in prostate cancer cells, the autophagy level was elevated under hypoxic condition, as well as the mRNA and protein level of ATG5, which is an important gene related to autophagy. Furthermore, we found HIF1α could directly bind to the promoter of ATG5 and promote the expression of ATG5 on transcriptional level by luciferase assay and ChIP assay. Intriguingly, overexpression of HIF1α by HIF1α-M could increase tumor size and the effect could be abolished by knockdown ATG5 by si-ATG5 in BALB/cA-nu/nu nude mice. Importantly, HIF1α could also promote the metastasis of PC-3 cells by upregulating the ATG5 and autophagy level and knockdown ATG5 and inhibition autophagy both could abolish the effect of overexpression of HIF1α on the migration of PC-3 cells. Taken together, our results, for the first time, proved that HIF1α could promote the proliferation and migration of PC-3 cells by direct upregulating ATG5 and autophagy level in PC-3 prostate cancer cells. Our findings not only provide new perspective for the relationship between hypoxia and autophagy, but also add new potential therapeutic regimens for the treatment of prostate cancers.

Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

An Jen Chiang,Min-Yu Chen,Chia-Sui Weng,Hao Lin,Chien-Hsing Lu,Peng-Hui Wang,Yu-Fang Huang,Ying-Cheng Chiang,Mu-Hsien Yu,Chih-Long Chang 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5

Objective: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT)to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiplemedical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, andprognostic factors of this disease and reviewed related literature. Methods: Pathological reports of 16,001 patients with primary ovarian cancer who weretreated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients withMT of MCT to SCC were identified. Results: Among all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age ofpatients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40cm). We analyzed the patients in our study and those in the literature and determined thatearly identification and complete surgical resection of the tumor are essential for long-termsurvival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be usedto treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTsare suitable indicators predicting the risk of MT of MCT to SCC. Conclusion: Similar to general epithelial ovarian cancers, the early detection of MT of MCTto SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should beevaluated to exclude potential MT to SCC.

AN ECONOMICAL VELOCITY PLANNING ALGORITHM FOR INTELLIGENT CONNECTED EVS BASED ON REAL-TIME TRAFFIC INFORMATION

Mingming Qiu,Lei Wang,Xiaoyu Mu,Wei Yu,Kang Huang 한국자동차공학회 2024 International journal of automotive technology Vol.25 No.2

The energy effi ciency of intelligent networked connected electric vehicle (EV) is directly related to its velocity. Aiming atthe infl uence of real-time traffi c fl ow information on road speed interval, a two-layer speed planning method is proposed. The upper layer extracts the road speed interval according to the traffi c fl ow information, and based on cellular automata andconfi dence interval theory, traffi c information rules are introduced, and a road speed interval extraction method consideringtraffi c density information is established. The lower layer is used to obtain energy-optimal cruising velocity profi le. Takingthe road speed interval as the variable boundary constraint, a dynamic programming algorithm that changes the state quantityboundary in real time is designed, which realizes the effi cient acquisition of the energy-optimized velocity trajectory. To verify the eff ectiveness of proposed approach, the simulation model is formulated based on using collected real traffi cinformation. The simulation results demonstrate that, compared with the conventional constant speed cruising strategy anddynamic programming (DP) strategy based on road speed interval, the strategy proposed in this study not only improvesenergy effi ciency and reduces computing time signifi cantly, but also can predict the traffi c conditions ahead to avoid largefl uctuations in velocity. Besides, the biggest signifi cance of this study is the designed economic velocity planning algorithmbased on real-time traffi c density information improves the adaptability of intelligent networked connected EV controlstrategy to actual traffi c conditions, and extends the optimization dimension of eco-driving.

공간정보정책 평가요인에 대한 AHP 분석

장우진(Jang, Woo Jin),이왕무(Lee, Wang Mu),유창호(Yu, Chang Ho) 한국지적정보학회 2014 한국지적정보학회지 Vol.16 No.3

본 연구는 지속가능한 공간정보정책 평가체계 구축을 위해 AHP 분석을 이용하여 전문가집단(연구원, 공무원, 교수)의 평가항목별 중요도 인식을 실증적으로 비교 분석하였다. 평가영역으로는 경제적측면, 정책적측면, 기술적측면, 사회적측면 등 4개 평가영역 하에 각각 3개씩의 평가항목으로 구성된 계층모형을 구성하였다. 실증 분석 결과, 집단별로 평가영역 및 평가항목에 대한 중요도 인식에는 차이점이 존재하였다. 그러나 전반적인 중요도 평가정향을 살펴보면, 먼저, 평가영역에 있어서는 사회적측면(.345), 경제적측면(.261), 정책적측면(.231), 기술적측면(.162)로 나타났다. 그리고 복합가중치를 적용하여 분석한 결과, 전반적으로 사회적 편익제공(.151), 민원활용도(.133), 정책의 효과(.109), 부가가치 창출(.108), 비용과 편익(.085), 시스템 연계(.075) 등이 중요한 평가항목으로 인식되고 있음을 확인할 수 있었다. 따라서, 전문가집단별로 공간정보정책 평가항목에 대한 상대적 중요도에 대한 인식에 차이가 있음을 고려할 때, 각 집단의 인식을 종합적으로 고려한 현행 평가지표 및 항목에 대한 재 검토가 이루어져야 할 것으로 판단된다. This study aims to build a sustainable spatial information policy evaluation index. For this reason, experts (researchers, government officials, professors) to the subject, the recognition of the importance of policy evaluation index was demonstrated analyzed using the AHP analysis. Four assessment domains are economic aspect, political aspects, technical aspects and social aspects. Hierarchical model is composed of three evaluation items(index) for each area. The results of empirical analysis, the difference was present in recognition of the importance of the evaluation domain and evaluation index for each group. Importance of the evaluation domain is Social aspects (.345), Economics aspect (.261), political aspects (.231), technical aspects (.162). The results were analyzed by applying the composite weight, provide a social benefit (.151), utilization of the petition (.133), the effect of the policy (.109), the creation of added value (.108), costs and benefits (.085), linkage system (.075) has been recognized as an important evaluation index. These results suggest that there is a difference in recognition to the index of spatial information policy evaluation between the expert group. Based on these findings, a review of the current metrics and items comprehensively considering the recognition of each expert group is determined to what should be done.

The Nedd8‐activating enzyme inhibitor MLN 4924 ( TAK ‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma

Zhang, Wenjuan,Liang, Yupei,Li, Lihui,Wang, Xiaofang,Yan, Zi,Dong, Changsheng,Zeng, Mu‐,Sheng,Zhong, Qian,Liu, Xue‐,Kui,Yu, Jinha,Sun, Shuyang,Liu, Xiaojun,Kang, Jihui,Zhao, Hu,Jeong, Lak BLACKWELL SCIENTIFIC PUBLICATIONS 2019 CELL PROLIFERATION Vol.52 No.2

Diverse Interpretations on Nativeness but Unanimous Subscription to Native-speakerism : Identity of Future Non-native English Teachers in Taiwan

Tzu-Bin Lin,Li-Yi Wang,Mu-Yu Wang 아시아영어교육학회 2018 The Journal of Asia TEFL Vol.15 No.3

In the current body of knowledge about the influence of native English-speaking teachers (NESTs) on the professional identity of non-native English-speaking teachers (NNESTs), the fundamental question of ‘What exactly do native English speakers (NESs) mean to NNESTs?’ has been left unanswered and the voices of preservice NNESTs are largely absent. This study examined the influence of NESTs as ‘significant others’ in the English language teaching profession on preservice NNESTs’ identity by looking into how preservice NNESTs interpret the term native English speakers, accept native speaker norms, and respond to the active recruitment of NESTs through the national policy in Taiwan. Survey and interview data were collected from 258 preservice English teachers. The findings show that although the participants held diverse views on who constitute NESs, they shared a unanimous subscribingto native-speakerism. The participants gave conditional support to the policy of recruiting NESTs while highlighting their opposition to uncertified NESTs and differentiated payment. Implications to teacher education and policy decisions are provided.