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- 저자 : Mount, C.W. (검색결과 12 건)
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The Mount Sinai Hospital Institute for critical care medicine response to the COVID-19 pandemic
Jennifer Wang,Evan Leibner,Jaime B. Hyman,Sanam Ahmed,Joshua Hamburger,Jean Hsieh,Neha Dangayach,Pranai Tandon,Umesh Gidwani,Andrew Leibowitz,Roopa Kohli-Seth,Mount Sinai Anesthesiology and Critical C 대한중환자의학회 2021 Acute and Critical Care Vol.36 No.3
Background: The coronavirus disease 2019 (COVID-19) pandemic resulted in a surge of critically ill patients. This was especially true in New York City. We present a roadmap for hospitals and healthcare systems to prepare for a Pandemic. Methods: This was a retrospective review of how Mount Sinai Hospital (MSH) was able to rapidly prepare to handle the pandemic. MSH, the largest academic hospital within the Mount Sinai Health System, rapidly expanded the intensive care unit (ICU) bed capacity, including creating new ICU beds, expanded the workforce, and created guidelines. Results: MSH a 1,139-bed quaternary care academic referral hospital with 104 ICU beds expanded to 1,453 beds (27.5% increase) with 235 ICU beds (126% increase) during the pandemic peak in the first week of April 2020. From March to June 2020, with follow-up through October 2020, MSH admitted 2,591 COVID-19-positive patients, 614 to ICUs. Most admitted patients received noninvasive support including a non-rebreather mask, high flow nasal cannula, and noninvasive positive pressure ventilation. Among ICU patients, 68.4% (n=420) received mechanical ventilation; among the admitted ICU patients, 42.8% (n=263) died, and 47.8% (n=294) were discharged alive. Conclusions: Flexible bed management initiatives; teamwork across multiple disciplines; and development and implementation of guidelines were critical accommodating the surge of critically ill patients. Non-ICU services and staff were deployed to augment the critical care work force and open new critical care units. This approach to rapidly expand bed availability and staffing across the system helped provide the best care for the patients and saved lives.
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Mount, Matthew P.,Zhang, Yi,Amini, Mandana,Callaghan, Steve,Kulczycki, Jerzy,Mao, Zixu,Slack, Ruth S.,Anisman, Hymie,Park, David S. American Society for Biochemistry and Molecular Bi 2013 The Journal of biological chemistry Vol.288 No.20
<P>We have earlier reported the critical nature of calpain-CDK5-MEF2 signaling in governing dopaminergic neuronal loss <I>in vivo</I>. CDK5 mediates phosphorylation of the neuronal survival factor myocyte enhancer factor 2 (MEF2) leading to its inactivation and loss. However, the downstream factors that mediate MEF2-regulated survival are unknown. Presently, we define <I>Nur77</I> as one such critical downstream survival effector. Following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment <I>in vivo</I>, <I>Nur77</I> expression in the nigrostriatal region is dramatically reduced. This loss is attenuated by expression of MEF2. Importantly, MEF2 constitutively binds to the <I>Nur77</I> promoter in neurons under basal conditions. This binding is lost following 1-methyl-4-phenylpyridinium treatment. <I>Nur77</I> deficiency results in significant sensitization to dopaminergic loss following 1-methyl-4-phenylpyridinium/MPTP treatment, <I>in vitro</I> and <I>in vivo</I>. Furthermore, <I>Nur77</I>-deficient MPTP-treated mice displayed significantly reduced levels of dopamine and 3,4-Dihydroxyphenylacetic acid in the striatum as well as elevated post synaptic FosB activity, indicative of increased nigrostriatal damage when compared with WT MPTP-treated controls. Importantly, this sensitization in <I>Nur77</I>-deficient mice was rescued with ectopic <I>Nur77</I> expression in the nigrostriatal system. These results indicate that the inactivation of <I>Nur77</I>, induced by loss of MEF2 activity, plays a critical role in nigrostriatal degeneration <I>in vivo</I>.</P>
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Sellers, D.L.,Kim, T.H.,Mount, C.W.,Pun, S.H.,Horner, P.J. IPC Science and Technology Press 2014 Biomaterials Vol.35 No.31
Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local injection of heparin before a spinal cord injury reduces cell proliferation and astrogliogenesis associated with scarring. We sought to create depot-formulations of PLGA microsphere and Pluronic F-127 for sustained local delivery of two thrombin inhibitors, heparin and hirudin. Each hydrogel depot-formulation showed delayed drug release compared to microspheres or hydrogel alone. Animals with a lateral demyelination lesion showed a reduction in CD68+ macrophages when treated with hirudin-loaded PLGA/F-127 gels compared to control and heparin-treated animals. Moreover, hirudin-loaded materials showed an accelerated recovery in coordinated stepping and increased oligodendrocyte densities. Together, these data demonstrate that controlled delivery of hirudin accelerates functional recovery from a demyelination lesion in the spinal cord.
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Developing a Smart Grid that Customers can Afford: The Impact of Deferrable Demand
( Wooyoung Jeon ),( Jung Youn Mo ),( Timothy D. Mount ) 한국환경경제학회, 한국자원경제학회 ( 구 한국환경경제학회 ) 2015 한국환경경제학회 학술발표논문집 Vol.2015 No.하계
With more electricity generated from renewable sources, the importance of effective storage capacity is increasing due to its capability to mitigate the inherent variability of these sources, such as wind and solar power. However, the cost of dedicated storage is high and all customers eventually have to pay. Deferrable demand offers an alternative form of storage that is potentially less expensive because the capital cost is shared between providing an energy service and supporting the grid. This paper presents an empirical analysis to illustrate the beneficial effects of Plug-in Hybrid Electric Vehicles (PHEV) and thermal storage on the total system cost using data for a hot summer day in New York City. The analysis shows how customers can reduce total system costs and their bills by 1) shifting load from expensive peak periods to less expensive off-peak periods, 2) reducing the amount of installed conventional generating capacity needed to maintain System Adequacy, and 3) providing ramping services to mitigate the variability of generation from renewable sources. Moreover, this paper demonstrates economic benefits of different types of customers with different deferrable demand capabilities under two bill payment policies, flat price payment and optimum price payment, and it finally shows how long it takes for customers to fully pay back their initial capital costs of PHEV or thermal storage under two different policies.
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Trapping and Cooling of 174Yb+ Ions in a Microfabricated Surface Trap
Rachel Noek,Taehyun Kim,Emily Mount,So-Young Baek,Peter Maunz,Jungsang Kim 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.4
Trapped atomic ions are the leading candidate to act as individual quantum bits in a large quantum information processing system. Ion traps can be conformed to a two-dimensional surface,which provides a way to increase the number of ions while maintaining the ability to move individual ions in a two-dimensional grid. However, surface traps tend to suffer from shallow trap depths and higher motional heating rates. In this work, we report the design, fabrication, and testing of a simple gold-on-fused-silica ion trap optimized for a deep trapping potential and stable motional modes. The desirable trap characteristics include long lifetime, fully-compensated micromotion,and high secular trap frequencies that were measured using a trapped and cooled 174Yb+ ion. This trap design can be integrated with an optical cavity to enhance the ion-photon coupling.
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Nodal probabilistic production cost simulation considering transmission system unavailabilty
Choi, J.,Tran, T.,Kwon, J.,Thomas, R.,Mount, T.,Billinton, R. IET 2008 IET generation, transmission & distribution Vol.2 No.1
<P>A nodal probabilistic production cost simulation method is described for power system long-term expansion planning considering unavailability and delivery limitation constraints of the transmission system. This new nodal production cost simulation model includes capacity constraints and unavailabilities of generators as well as transmission lines. This simulation methodology comes from the nodal composite power system equivalent load duration curve (CMELDC), based on a new effective load model at load points developed by the authors. The nodal CMELDC can be obtained from convolution integral processing of the outage capacity probability distribution function of the fictitious generator and the original LDC. It is expected that the new simulation model based on the nodal CMELDC proposed here will provide solutions to many problems based on nodal and decentralised operation and control of electric power systems under a competition environment. The nodal CMELDC based on the new model at load points can extend application areas of nodal probabilistic production cost simulation, probabilistic congestion cost assessment, analytical outage cost assessment and nodal reliability evaluation and so on at load points. The characteristics and effectiveness of this new proposed methodology are illustrated by a small system case study using a network flow and enumeration method.</P>
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