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( Morteza Entezari ),( Alireza Ramezani ),( Mehdi Yaseri ) 대한안과학회 2012 Korean Journal of Ophthalmology Vol.26 No.2
In a clinical case series, 5 patients with not-resolved central serous choroidoretinopathy (CSC) lasting more than 1 year received one intravitreal bevacizumab injection (IVB, 1.25 mg) injection. All patients underwent a through ophthalmic examination 1 day, 1 week, and 1, 2, and 6 months after the injection. Best corrected visual acuity (BCVA) and central macular thickness were compared before and after treatment by optical coherence tomography. Mean BCVA was improved significantly (p=0.020) from 0.60±0.25 to 0.50±0.18 and 0.29±0.19 logarithm of minimum angle of resolution at 6 and 18 weeks, respectively. Central macular thickness was also decreased significantly (p=0.010) from 370±65 to 208±23 μm at 4 months. No recurrence was occurred during follow-up. IVB injection may have beneficial effect in the treatment of refractory CSC.
Alireza Ramezani,Morteza Entezari,Mohammad Mehdi Shahbazi,Yosef Semnani,Homayoun Nikkhah,Mehdi Yaseri 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.2
Purpose: To evaluate the analgesic effect of topical sodium diclofenac 0.1% before retinal laser photocoagulationfor diabetic retinopathy. Methods: Diabetic patients who were candidates for peripheral laser photocoagulation were included in a randomized,placebo-controlled, intraindividual, two-period, and crossover clinical trial. At the first session andbased on randomization, one eye received topical sodium diclofenac 0.1% and the other eye received an artificialtear drop (as placebo) three times before laser treatment. At the second session, eyes were given thealternate drug. Patients scored their pain using visual analogue scale (max, 10 cm) at both sessions. Patientsand the surgeon were blinded to the drops given. Difference of pain level was the main outcome measure. Results: A total of 200 eyes of 100 patients were enrolled. Both treatments were matched regarding the appliedlaser. Pain sensation based on visual analogue scale was 5.6 ± 3.0 in the treated group and 5.5 ± 3.0 in thecontrol group. The calculated treatment effect was 0.15 (95% confidence interval, –0.27 to 0.58; p = 0.486). The estimated period effect was 0.24 (p = 0.530) and the carryover effect was not significant (p = 0.283). Conclusions: Pretreatment with topical sodium diclofenac 0.1% does not have any analgesic effect during peripheralretinal laser photocoagulation in diabetic patients.
Predictors and Outcomes of Vitrectomy and Silicone Oil Injection in Advanced Diabetic Retinopathy
Alireza Ramezani,Hamid Ahmadieh,Amin Rozegar,Masoud Soheilian,Morteza Entezari,Siamak Moradian,Mohammad H Dehghan,Homayoun Nikkhah,Mehdi Yaseri 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.3
Purpose: To evaluate visual and anatomical results and identify factors that influence vitrectomy and silicone oil(SO) injection outcomes in proliferative diabetic retinopathy (PDR). Methods: This retrospective study included 236 eyes with PDR that were undergoing vitrectomy and SO injectionwith >3-month follow-up. The primary outcomes were final best-corrected visual acuity (BCVA) and retinalattachment rate. Results: At the final visit (mean, 88 ± 58 weeks), complete, partial, and no retinal attachment were observed in86.9%, 10.6%, and 2.5% of patients, respectively. A total of 155 eyes had experienced SO removal, while 81had SO in place. The mean initial BCVA was 1.9 ± 0.7 logarithm of the minimum angle of resolution (logMAR)and significantly improved to 1.7 ± 0.8 logMAR (p = 0.001). Initial macular detachment (adjusted odds ratio[AOR], 0.25), development of iatrogenic break (AOR, 0.25), and use of heavy SO (AOR, 0.13) were independentlyassociated with a lower risk of final retinal attachment, and SO removal was associated with a higherincidence (AOR, 7.55). Better baseline BCVA was associated with a higher risk of final BCVA ≥20 / 200. Conclusions: Despite an encouraging outcome based on anatomical data in advanced PDR treated with vitrectomyand SO, the functional prognosis was not satisfying for patients. Eyes with better vision at baseline hada more favorable prognosis, whereas eyes with initial macular detachment, intraoperative iatrogenic break, orheavy SO showed more unfavorable outcomes. In selected cases, extending the time of SO use did not worsenthe prognosis.