http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Roles of RIPK3 in necroptosis, cell signaling, and disease
Morgan Michael J.,Kim You-Sun 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the “programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is activated by the death receptor ligands and pattern recognition receptors of the innate immune system, and the findings of many reports have suggested that necroptosis is highly significant in health and human disease. This significance is largely because necroptosis is distinguished from other modes of cell death, especially apoptosis, in that it is highly proinflammatory given that cell membrane integrity is lost, triggering the activation of the immune system and inflammation. Here, we discuss the roles of RIPK3 in cell signaling, along with its role in necroptosis and various pathways that trigger RIPK3 activation and cell death. Lastly, we consider pathological situations in which RIPK3/necroptosis may play a role.
Morgan Chabanon,Hervé Duval,Jérôme Grenier,Claire Beauchesne,Benoit Goyeau,Bertrand David 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.3
BACKGROUND: Tissue engineering represents a promising approach for the production of bone substitutes. The use of perfusion bioreactors for the culture of bone-forming cells on a three-dimensional porous scaffold resolves mass transport limitations and provides mechanical stimuli. Despite the recent and important development of bioreactors for tissue engineering, the underlying mechanisms leading to the production of bone substitutes remain poorly understood. METHODS: In order to study cell proliferation in a perfusion bioreactor, we propose a simplified experimental set-up using an impermeable scaffold model made of 2 mm diameter glass beads on which mechanosensitive cells, NIH-3T3 fibroblasts are cultured for up to 3 weeks under 10 mL/min culture medium flow. A methodology combining histological procedure, image analysis and analytical calculations allows the description and quantification of cell proliferation and tissue production in relation to the mean wall shear stress within the bioreactor. RESULTS: Results show a massive expansion of the cell phase after 3 weeks in bioreactor compared to static control. A scenario of cell proliferation within the three-dimensional bioreactor porosity over the 3 weeks of culture is proposed pointing out the essential role of the contact points between adjacent beads. Calculations indicate that the mean wall shear stress experienced by the cells changes with culture time, from about 50 mPa at the beginning of the experiment to about 100 mPa after 3 weeks. CONCLUSION: We anticipate that our results will help the development and calibration of predictive models, which rely on estimates and morphological description of cell proliferation under shear stress.
Morgan, John J. 강남대학교 부설 한국사회복지연구소 2001 한국사회복지 Vol.5 No.-
Grief is an individual and natural response to a loss, and every person will integrate the death into their life, in their own way. Approximately one-third of bereaved individuals will have enough social support from family, friends and the community at large so that no additional help will be sought. Approximately one-third will require and seek aid from mutual help organizations; others need the support of grief counselling, that is, facilitation with "uncomplicated, or normal, grief to a healthy compoleting of the tasks of grieving within a reasonable time frame," and a small minoity require grief therapy "those specialized techniques ... what are used to help people with abnormal or complicate reactions."
Rethinking the Basis of Security in and for Korea
Morgan, Patrick M. 경희대학교 아태지역연구원 1996 아태연구 Vol.3 No.-
I am greatly honored to have been invited to contribute to this special issue of Asia-Pacific Studies. Since the invitation arrived relatively close to the deadline, I have offered what amounts to an extended essay rather than a research paper, drawing on a recent study of mine on US-North Korean relations^1) and on a study in progress on the future of deterrence in and around the Korean prninsula.
Pentacyclic triterpenes from the stem bark of <i>Combretum hartmannianum</i> Schweinf
Morgan, Abubaker M.A.,Mohamed, Azmey E.,Saophea, Chhon,Park, Sang Un,Kim, Young Ho Elsevier 2018 Biochemical systematics and ecology Vol.77 No.-
<P><B>Abstract</B></P> <P>Chemical investigation of the stem bark of <I>Combretum hartmannianum</I> Schweinf (Combretaceae) led to the isolation and identification of nine compounds with pentacyclic triterpene skeletons. These were identified as three ursane-type triterpenes, ursolic acid (<B>1</B>), pomolic acid (<B>2</B>), and corosolic acid (<B>3</B>); one oleanane-type triterpene, arjunic acid (<B>4</B>); and five oleanane-type triterpene glucosides, arjunglucoside I (<B>5</B>), trachelosperoside E-1 (<B>6</B>), combreglucoside (<B>7</B>), chebuloside II (<B>8</B>), and 2α,3β,6β,19α-tetrahydroxyoleanolic acid 28-<I>O</I>-β-<SMALL>D</SMALL>-glucopyranoside (<B>9</B>). The chemical structures of these compounds were elucidated from spectroscopic data and by comparison of these data with previously published results. This is the first report of triterpene compounds from a species of <I>C. hartmannianum</I> and the first report of compounds <B>2</B> and <B>9</B> from a member of the Combretaceae family.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This study is the first comprehensive chemical investigation of <I>Combretum hartmannianum</I> Schweinf. </LI> <LI> Nine compounds were reported first herein as isolates from <I>C. hartmannianum</I>, and compounds 2 and 9 are reported for the first time from Combretaceae family. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Concurrency Conflicts Resolution for IoT Using Blockchain Technology
Morgan, Amr,Tammam, Ashraf,Wahdan, Abdel-Moneim International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.7
The Internet of Things (IoT) is a rapidly growing physical network that depends on objects, vehicles, sensors, and smart devices. IoT has recently become an important research topic as it autonomously acquires, integrates, communicates, and shares data directly across each other. The centralized architecture of IoT makes it complex to concurrently access control them and presents a new set of technological limitations when trying to manage them globally. This paper proposes a new decentralized access control architecture to manage IoT devices using blockchain, that proposes a solution to concurrency management problems and enhances resource locking to reduce the transaction conflict and avoids deadlock problems. In addition, the proposed algorithm improves performance using a fully distributed access control system for IoT based on blockchain technology. Finally, a performance comparison is provided between the proposed solution and the existing access management solutions in IoT. Deadlock detection is evaluated with the latency of requesting in order to examine various configurations of our solution for increasing scalability. The main goal of the proposed solution is concurrency problem avoidance in decentralized access control management for IoT devices.