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Moon, Hae-Jeong,Lee, Bo-Young,Choi, Giltsu,Shin, Dong-Jin,D. Theertha Prasad,Lee, Ok-Sun,Kwak, Sang-Soo,Kim, Doh-Hoon,Nam, Jae-Sung,Bahk, Jeong-Dong,Hong, Jong-Chan,Lee, Sang-Yeol,Cho, Moo-Je,Lim, Cha Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-
NDP kinases (NDPKs) are multifunctional proteins that regulate a variety of eukaryotic cellular activities, including cell proliferation, development, and differentiation. However, much less is known about the functional significance of NDPKs in plants. We show here that NDPK is associated with H_(2)O_(2)-mediated mitogen-activated protein kinase signaling in plants. H_(2)O_(2)stress strongly induces the expression of the NDPK2 gene in Arabidopsis thaliana (AtNDPK2). Proteins from transgenic plants overexpressing AtNDPK2 showed high levels of autophosphorylation and NDPK activity, and they have lower levels of reactive oxygen species (ROS) than wild-type plants. Mutants lacking AtNDPK2 had higher levels of ROS than wild type. H_(2)O_(2) treatment induced the phosphorylation of two endogenous proteins whose molecular weights suggested they are AtMPK3 and AtMPK6, two H_(2)O_(2)-activated A. thaliana mitogen-activated protein kinses. In the absence of H_(2)O_(2) treatment, phosphorylation of these proteins was slightly elevated in plants overexpressing AtNDPK2 but markedly decreased in the AtNDPK2 deletion mutant. Yeast two-hybrid and in vitro protein pull-down assays revealed that AtNDPK2 specifically interacts with AtMPK3 and AtMPK6. Furthermore, AtNDPK2 also enhances the myelin basic protein phosphorylation activity of AtMPK3 in vitro. Finally, constitutive overexpression of AtNDPK2 in Arabidopsis plants conferred an enhanced tolerance to multiple environmental stresses that elicit ROS accumulation in situ. Thus, AtNDPK2 appears to play a previously uncharacterized regulatory role in H_(2)O_(2)-mediated MAPK signaling in plants.
Moon, Hae-Jeong,Baek, Dong-Won,Lee, Bo-Young,D. Theertha Prasad,Lee, Sang-Yeol,Cho, Moo-Je,Lim, Chae Oh,Choi, Myung-Suk,Bahk, Jeong-Dong,Kim, Myeong-Ok,Hong, Jong-Chan,Yun, Dae-Jin Plant molecular biology and biotechnology research 2002 Plant molecular biology and biotechnology research Vol.2002 No.-
Bax, a mammalian proapoptotic member of the Bcl-2 family, can induce cell death when expressed in yeast or plant cells. To identify plant Bax inhibitors, we cotransformed a soybean cDNA library and the Bax gene into yeast cells and screened for expressed genes that prevented Bax-induced apoptosis. From the Bax-inhibiting genes isolated, ascorbate peroxidase (aAPX) was selected for characterization. The transcription of aAPX in plants was specifically induced by oxidative stress. Moreover, overexpression of aAPX partially suppressed the H_(2)D_(2)-sensitive phenotype of yeast cytosolic catalase T (Δctt)- and thermosensitive phenotype of cytochrome c peroxidase (Δccp)-deleted mutant cells. Examination of reactive oxygen species (ROS) production using the fluorescence method of dihydrorhodamine 123 oxidation revealed that expression of Bax in yeast cells generated ROS, which was greatly reduced by coexpression with sAPX. Our results collectively suggest that sAPX inhibits the generation of ROS by Bax, which in turn suppresses Bax-induced cell death in yeast.
임재현,이혜란,심영보,한연석,이윤우,박문향,송태의,서상렬 인제대학교 백병원 2001 仁濟醫學 Vol.22 No.2
A 41-year-old female patient was admitted with uncontrolled gum bleeding and severe pancytopenia. She had a history of systemic lupus erythematosus(SLE) for 2 years prior to the identification of marrow fibrosis. Myelofibrosis is characterized by excessive deposition of collagen, laminin, and fibronectin within the bone marrow stroma. These changes can be due to primary myeloproliferative disorders, a variety of malignant processes, endocrine disturbances, or inflammatory diseases. Myelofibrosis is a rare cause of cytopenias in SLE, and conversely SLE is an uncommon etiology for myelofibrosis. We report a case of myelofibrosis secondary to systemic lupus erythematosus which was reversed by the treatment with glucocorticoid.
Genetic Polymorphism in Corticotropin-releasing Hormone Receptor Type-1 in Preeclamptic Korean Women
Lim, Ji-Hyae,Kim, Shin-Young,Park, So-Yeon,Kim, Do-Jin,Kim, Mi-Jin,Ahn, Hyun-Kyong,Han, Jung-Yeol,Kim, Moon-Young,Park, Hyun-Young,Lee, Kwang-Soo,Kim, Young-Ju,Ryu, Hyun-Mee Korean Society of Medical Genetics and Genomics 2011 대한의학유전학회지 Vol.8 No.2
목적: Corticotropin-releasing hormone receptor type 1(CRHR1)은 자간전증과 같은 비정상적인 태반의 기능을 가지는 산모에서 감소되어 나타나며, 그것의 발현이나 기능은 유전적으로 영향을 받는다. 이번 연구의 목표는 한국인에서 CRHR1 유전자 다형성인 c.33+8199C>T과 자간전증 사이의 연관성을 조사하는 것이었다. 대상 및 방법: CRHR1 유전자 다형성은 SNapShot kit와 ABI Prism3100 Genetic analyzer를 이용하여 203명의 자간전증 임산부와 211명의 정상 임산부에서 측정되었고, 유전자 다형성과 자간전증 위험도 사이의 연관성을 분석하였다. 결과: CRHR1 유전자 다형성의 유전자형과 대립유전자 빈도는 자간전증 임산부와 정상 임산부 사이에 다르지 않았다. 자간전증 발생 위험도는 분석된 유전자 다형성의 드문 대립 형질(C)을 지닌 이종접합 유전자형(TC)이나 동형접합 유전자형(CC)을 수반하는 그룹에서 증가되지 않았다. CRHR1 유전자의 동형접합 유전자형(CC)을 수반하는 그룹에서 중증 자간전증과 조기 자간전증과 같은 자간전증의 합병증 발병 위험에도 차이가 없었다. 결론: 이 연구는CRHR1 유전자 다형성인 c.33+8199C>T가 한국인 임신부의 자간전증 발생과 연관이 없음을 나타낸다. Purpose: Placental corticotropin-releasing hormone receptor type 1 (CRHR1) expression is reduced in pregnancies with abnormal placental function such as preeclampsia (PE), and the levels and/or function of CRHR1 are genetically influenced. The aim of this study was to investigate the association between the c.33+8199C>T polymorphism in the CRHR1 gene and PE in a Korean population. Materials and Methods: Using a case-control design, the association between the CRHR1 polymorphism and the risk of PE was investigated in 203 individuals with PE and 211 normotensive controls. Genotypes were determined using a SNapShot kit and an ABI Prism 3100 Genetic analyzer. Results: Genotypes and allele frequencies for the CRHR1 polymorphism did not differ between PE and normotensive pregnancies. The variant T allele was more frequent than the ancestral C allele in both of the groups and was more frequent in the controls than in the cases. In risk analysis for PE, there was not an increased risk of preeclampsia in subjects who were concomitant homozygous rare allele genotypes (CC) (OR, 0.3; P=0.15) or heterozygous rare allele genotypes (TC) (OR, 0.8; P=0.29). There were no differences in the complications of PE such as severity or preterm delivery in patients with the CRHR1 polymorphism. Conclusion: Our findings indicate that the CRHR1 polymorphism was not associated with PE in the present Korean study group.
Woo-Yeol Shin,Gi-Moon Hong,Hyongmin Lee,Jae-Duk Han,Kyu-Sang Park,Dong-Hyuk Lim,Sunkwon Kim,Daeyong Shim,Jung-Hoon Chun,Deog-Kyoon Jeong,Suhwan Kim IEEE 2013 IEEE transactions on components, packaging, and ma Vol.3 No.5
<P>In this paper, we introduce an impedance-matched bidirectional multidrop (IMBM) DQ bus, together with a 4.8-Gb/s transceiver for a memory controller that supports this bus. Reflective ISI is eliminated at each stub of the IMBM DQ bus by resistive unidirectional impedance matching. A prototype memory controller transceiver is designed and fabricated in a 0.13-μm CMOS process and operates with a 1.2-V supply voltage. Its effectiveness is shown on various multidrop channel configurations. At 4.8 Gb/s, this transceiver with a 4-slot, 8-drop IMBM DQ bus has an eye opening of 0.39 UI in TX mode and 0.58 UI in RX mode, at a threshold of 10<SUP>-9</SUP> BER, whereas a comparable transceiver with a conventional 4-slot, 8-drop stub series terminated logic has no timing margin under the same test conditions. Our transceiver consumes 14.25 mW/Gb/s per DQ in TX mode, and 13.69 mW/Gb/s per DQ in RX mode.</P>