2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

非行靑少年의 行動障碍分類를 위한 理論的 背景의 小考

文宣和,李璟禧 부산대학교 사회과학대학 1990 社會科學論叢 Vol.9 No.1

In helping the child who has problems, measuring method is required in order to identify what the problem is. By the way, the tests of juvenile delinquent have not been made systematically yet. We are aware that the methods of coping with juvenile delinquents will be not so useful unless the bases for treating and correcting them fundamentally are provided. Accordingly, in this study we attempt to consider about tools to measure their adaptive-maladaptive behaviors as the first step of a series of helping process in order that the child can live as a sound citizen and the significance of his problem can be minimized through helping to assess it correctly. Though it defines and classifies differently according to settings which a behavior rises and is evaluated, the adaptive behavior, here, is defined one which can be accepted socially in accordance with his age and development, and can meet the members' expectation in the society. Then, the child who shows anti-sociality, anxiety, regression introvert behavior and passive and autistic tendency, is defined as a maladaptive behavior. By the definition, we referred to some ABS as adaptive-maladaptive measures to diagnose the mental retardation and the emotional/behavioral disorder, and considered the way which those are used in practice and what is asked about each measure. And we investigated all kinds of testing methods being used presently in order to identify and understand their backgrounds, in our Juvenile Justice System. Each setting to be able to apply to the ABS in this process was also considered.

루터의 십자가 신학과 득의

문선희 연세대학교 신과대학 2004 신학논단 Vol.35 No.-

D-Amino Acid Aminotransferase 활성보유 고온성미생물의 탐색 및 분류학적 특성 연구

곽미선,이승구,정상철,서승현,이재흥,전영중,김영호,성문희 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

To acquire an industrially useful biocatalyst for the enzymatic synthesis and production of various D-amino acids, 1,300 thermophiles isolated from the soil of Korea were analyzed for D-amino acid aminotransferase (D-AAT) activity. The enzyme activity was found from 110 strains of isolated thermophiles revealing its wide occurrence in thermophiles. Enzyme activity and thermal stability of the D-AAT producers were compared. Finally we have selected four thermophiles as producers of potent biocatalysts for the D-amino acid production; two therrnophiles, Bacillus sp. LK-I and LK-2, having higher specific activity and two thermophiles, B. stearothermophilus KL-01 and Bacillus sp. KLS-0l, having higher thermal stability than the D-AAT producers. Taxonomic and physiological characteristics of the four isolated thermophiles were described herein.

2-[(4-Cyanophenyl)amino]-3-chloro-1,4-naphthalenedione(NQ-Y15)의 돌연변이원성

김봉희,정기화,유충규,창동신,이기선,전선덕,소동수,채상호,문창규 한국환경독성학회 2000 환경독성보건학회지 Vol.15 No.4

2-[(4-Cyanophenyl)amino]-3-chloro-1, 4-naphthalenedione (NQ-Y15) was asssayed for its genotoxic potential by using Salmonella typhimurium reversion assay and in vitro chromosome aberration test on Chinese hamster lung cells. In the Ames test, NQ-Y 15 induced his+ revertants of Salmonella typhimurium TA 98 and TA1537, reaching levels twice the negative control values. But, NQ-Y15 induced only his^(+) revertants of Salmonella typhimurium TA1537 more than twice the control values under the condition with metabolic activation system. In the cytogenetic test on chinese hamster lung cells, NQ-Y15 showed significant chromosomal aberrations, but the incidence was significantly reduced in the presence of metabolic activation.

공구형상인자에 따른 공구응력 변화 특성

이영문,손재환,김선일,정희철 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

In this study, a series of FE-simulations, using the DEFORM software, on tool stersses of orthogonal cutting are carried out. As cutting input conditions, the tool shape factor such as tool relief angle and the cutting velocity are changed in the analyses. The results reveal that the patterns of stress distribution are same, that is signs of stress are divided at the points, wherever the chips leave the tool. And as the relief angle increases the more sterss concentration occurs at the tool tip.

乳酸菌에 의한 돼지설사 원인균의 生育沮害

姜國熙,成文喜,李仁善,申鉉靖 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.1

E. coli A_2 and G_7 occurring bacterial diarrhea of pigs were inoculated with 10^5/ml into thioglycollate medium without indicator-135C, and then Str. faecium and Str. faecalis var. liquefaciens were inoculated with 10^5/ml and 10^7/ml into previous inoculated samples of E. coli A_2 and G_7. Inoculated samples cultured at 37℃, were tested to determine changes in viable numbers of organisms and pH. The experimental results are summerized as follows: 1. In the mixed culture medium of 10^5/ml E. coli and 10^5/ml Streptococci, E. coli decreased after 8 hours from incubation, and finally decreased to 10^1/ml after 48 hours. 2. In the mixed culture medium of 10^5/ml E. coli and 10^7/ml Streptococci, E. coli drastically decreased, were not disappeared after 36 hours. 3. The pH value of the pure culture of E. coli was 5.30 and in the mixed culture of E. coli and Streptococci the pH value was 4.49-4.80 after 8 hours from incubation.

자연치와 복합레진의 색 분포에 관한 연구

김희선,이인복,엄정문 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.2

The structure of current guides is largely illogical and without any rational use of color ordering. The shade guides are generally made of plastic (rather than the actual composite material) and do not accurately depict the true shade, translucency, or opacity of the composite resin after polymerization. To solve this problem, information based on evaluations of natural teeth and material that use the same method and experimental conditions is necessary. The present investigation measured the color of natural maxillary anterior teeth in vivo and compared the results with those of composite resins. 269 Korean subjects were selected for this study. Intact central incisor, lateral incisor, and canine were selected. The clinical crowns were free of caries or restorations. The middle site of the coronal portion on the labial surface of the tooth was measured by Chroma Meter. The five light activated, resin-based materials(Amelogen, Denfil, Elitefil, Spectrum, Z100) were used in this study. Resin composite was condensed into plastic mold with a diameter of 8mm and a thickness of 4mm, pressed between glass plates to flatten the surfaces, and polymerized using a Visilux II visible light-activation unit, The surfaces were polished sequentially on wet sandpaper. Color measurements of each specimen were accomplished by Chroms Meter. A compute program that compares each tooth color with each composite resin color was written and the minimum CIELAB color difference(ΔE*) between tooth and each material was calculated. Under the conditions of this study: 1.Teeth tend to become darker with advancing age. 2.Canines were darker, more yellow, and less green than incisors. 3.The teeth from the women were lighter, more green, and less yellow than the male teeth. 4.In general, composite resins were lighter, more green, and less yellow than teeth. Deficiencies were noted in Hues in YR range. 5.Mean color differences between the five composite resin products and teeth were detectable to the naked eye(ΔE*>1.0). 6.In comparing the mean ΔE* values of materials, Spectrum showed the least followed by Z100, Elitefil, Amelogen, Denfil in increasing order.

疎風湯의 消炎·鎭痛作用에 관한 硏究

劉善美,林起龍,嚴基鎭,文永熙 조선대학교 약학연구소 1993 藥學硏究誌 Vol.15 No.1

This study was attempted to examine the effect of Sopung-Tang extract(STE) on anti-inflammatory action in rats, analqesic action and the acute, subacute toxicity in mice. In anti-inflammatory activity in rats, STE was shown to have significant preventive effect in the edema induced by Freund's conplete adjuvant and 5% acetic acid. In analgesic activity in mice, STE was shown to have significant analgesic action on the writhing syndrome in mice induced by 0.7% acetic acid. In acute toxicity test in mice, STE showed 10% mortality at 2000㎎/㎏ . and 1200㎎/㎏ i.p. In subacute toxicity test in mice, STE was not showed for 19 days. Serum uric acid in treated by adjuvant method rats were slightly decreaced by comparing with the control group. During the administration of extracts the body weight increased, but the liver and spleen weight was not changed.

2-[(4-Cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15)의 돌연변이원성

김봉희,정기화,유충규,창동신,이기선,전선덕,소동수,채상호,문창규 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1

2-[(4-Cyanophenyl)amino]-3-chloro-1, 4-naphthalenedione (NQ-Y15) was asssayed for its genotoxic potential by using Salmonella typhimurium reversion assay and in vitro chromosome aberration test on Chinese hamster lung cells. In the Ames test, NQ-Y15 induced his+revertants of Salmonella typhimurium TA 98 and TA 1537, reaching levels twice the negative control values. But, NQ-Y15 induced only his+revertants of Salmonella typhimurium TA 1537 more than twice the control values under the condition with metabolic activation system. In the cytogenetic test on chinese hamster lung cells. NQ-Y15 showed significant chromosomal aberrations, but the incidence was significantly reduced in the presence of metabolic activation.