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RISS 인기검색어
- 검색키워드
- 저자 : Moon Su-Yuon (검색결과 2 건)
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Shin, Soo Jung,Jeong, Yuon,Jeon, Seong Gak,Kim, Sujin,Lee, Seong-kyung,Choi, Hong Seok,Im, Cheong Su,Kim, Seong Hee,Kim, Soo Hwan,Park, Jae Ho,Kim, Jin-il,Kim, Jwa-Jin,Moon, Minho Elsevier 2018 Neurochemistry International Vol.121 No.-
<P><B>Abstract</B></P> <P>One of the pathological hallmarks of Alzheimer's disease (AD) is the abnormal aggregation of amyloid beta (Aβ) peptides. <I>Uncaria rhynchophylla</I> (UR), one of the <I>Uncaria</I> species, has long been used to treat neurodegenerative disease. In particular, it has been reported that UR inhibits aggregation of Aβ <I>in vitro.</I> However, little is known about the histological effects of UR treatment on Aβ pathology in AD animal models. In the present study, we investigated the effect of UR on Aβ aggregation, Aβ-mediated pathologies and adult hippocampal neurogenesis in the brain of 5XFAD mice. First, using the thioflavin T assay and amyloid staining, we demonstrated that UR treatment effectively inhibited Aβ aggregation and accumulation in the cortex and subiculum. Second, immunofluorescence staining showed that administration of UR attenuated gliosis and neurodegeneration in the subiculum and cortex. Third, UR treatment ameliorated impaired adult hippocampal neurogenesis. The present results indicate that UR significantly alleviates Aβ deposition and Aβ-mediated neuropathology in the brain in 5XFAD mice, suggesting the potency of UR as a preventive and therapeutic agent for AD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>Uncaria rhynchophylla</I> (UR) inhibited Aβ aggregation and accumulation. </LI> <LI> UR alleviated neuroinflammation induced by Aβ. </LI> <LI> Treatment of UR relieved synaptic and neuronal loss in AD mice. </LI> <LI> UR attenuated impaired hippocampal neurogenesis induced by Aβ. </LI> </UL> </P>
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손창현,최승,문수연,김재영,이열화,Sohn Chang-Hyun,Choi Seung,Moon Su-Yuon,Kim Jae-Yung,Lee Yul-Hwa 한국군사과학기술학회 2004 한국군사과학기술학회지 Vol.7 No.3
Matching inviscid and boundary layer methods are developed for analysis of hypersonic flow with thick boundary layer. The new equations match all the boundary layer properties with a variation in the inviscid solution near the edge, except for the normal velocity. Computational comparison are peformed for incompressible and compressible flows over a flat plate. Results from the present method are compared with Wavier-Stokes solutions. The present results are in good agreement with Wavier-Stokes solutions. They show that the new technique can provide improved predictions of heating rates and skin friction predictions for preliminary design of vehicles where shear layers and entropy layer swallowing are importantfor for preliminary design.
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