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류장근,김용문,노병의 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1996 Journal of biomedical laboratory sciences Vol.2 No.1
대구 및 경북지역 일부 유치원생들의 최근 요충감염 상태를 조사하기 위하여 도시지역으로는 대구광역시 수성구 지역 14개 유치원과 농촌지역으로는 경북 경산시의 면단위 소재지 11개 유치원에서 4, 5, 6, 7세 어린이 1,087명(남:611, 여:476)을 대상으로 Graham씨의 Scotch tape법으로 1회 항문주위도말검사를 실시하였다. 도시지역 유치원생들의 요충감염율은 검사자 643명중 양성자가 62명으로 9.6%였고, 농촌지역은 444명중 양성자가 45명으로 10.1%였다. 연령별 검사성적에서는 7세에서 도시지역에서는 128명중 7명이 양성자로 나타나 5.5%의 양성률을 보였고, 농촌지역에서는 87명중 21명이 양성자로 나타나 24.1%의 양성률을 보여 농촌지역 유치원생들이 도시지역 유치원생들 보다 요충감염율이 훨씬 높게 나타났다(P<0.01). 도시지역 연령별 전체 요충감염 상태는 4세 6.3%, 5세 8.4%, 6세 19.3%로 연령이 높아질수록 증가하는 경향을 보였으나 7세에서는 5.5%로 낮게 나타났다(P<0.01). 농촌지역 연령별 전체 요충감염 상태는 4세가 2.3%, 5세가 7.0%, 6세가 9.8%, 7세가 24.1%로 연령이 높아질수록 감염율이 높았다(P<0.01). Recent patterns of Enterobius vermicularis infection in some kindergarten children was performed in Taegu and Kyongbuk Area from June, 1995 through August 30, 1995. A total of 1,087 children (male 611 and female 476) were examined by Graham's, and of 444 rural children, 45(10.1%) were infected. Of 354 male children in urban area 40(11.3%) were E. vermicularis positive and of 257 male children in rural area, 28(10.9%) were E. vermicularis positive. Of 128 children in the age of 7 years old in urban area, 7(5.5%) were E. vermicularis positive but of 87 children in the same age group in rural area, 21(24.1%) were E. vermicularis positive (P<0.01). Of 354 male children in urban area, 40(11.3%) were E. vermicularis positive and 289 female children in the same area 22(7.6%) were infected by E. vermicularis. The E. vermicularis infection rates in the children in the age group of 4,5, and 6 were 6.3%, 8.4% and 19.3% respectively, and the rate for 7 year old children was 5.5% (P<0.01). In rural area, 28(10.9%) of 257 male children had E. vermicularis and 17(9.1%) of 187 female children had E. vermicularis. The E. vermicularis infection rates in the age groups of 4, 5, 6 and 7 were 2.3%, 7.0% 9.8% and 24.1% respectively and the difference in rates were statistically significant(P<0.01).
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鄭文植,金文昭,盧炳宣 최신의학사 1972 最新醫學 Vol.15 No.3
The demand of water is rapidly increasing with the growth of population in Seoul area. The city government has recently devoted itself to the quantitative production of water without overall supply system planning. Dirty water might leak in the pipe and contaminate the supply water because more than 40 years old pipes are still using by connecting with new pipes, numerous private water companies are continuously installing distribution systems at-.individual houses, and the supply is intermittent in some areas. A survey was undertaken to find out the pollution status of supply, mainly, by leakage of pipes. Coliform groups by the membrane filter technic and residual chlorine were examined with 93 samples of tap water collected in whole Seoul areas from June 29 to September 26, 1970, and following results were obtained: 1. Do residual chlorine was found at 24(26%) out of 93 samples, while 49 samples(53%) contained 0. 1 to 0. 5 ppm, 17(18%), 0.6 to 1. 0 ppm, and 3(3%), 1. 1 to 1. 5 ppm. At Mapo-ku, 6 out of 11 samples have no residual chlorine and 4 out of 10 have no at Sudaemoon-ku. 2. coliform groups were found at 13(14%) out of 93 samples when 100 ml tap waters were tested by the membrane filter technic and other microorganisms at 6(6%). Coliforms were detected at 4 out of 11 samples in Sungbuk-ku, 3 out of 11 in Dongdaemoon-ku, 1 out of 5 at Yungdungpo-ku while no coliforms were detected from 12 samples at Yongsan-ku. 3. coliform groups positives were 4(17%) out of 24 samples with no residual chlorine, 8(16%) out of 49 with 0.1 to 0.5 ppm, 1 out of 17 with 0.6 to 1.0 ppm and none out of 3 with 1.1 to 1.5 ppm.
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Identification of Potential Serum Biomarkers in Mercury-Treated Mice Using a Glycoproteomic Approach
Kim, Bong-Hwa,Moon, Pyong-Gon,Lee, Jeong-Eun,Lee, Soyoung,Kim, Sook-Kyung,Lee, Jong Kwon,Kim, Sang-Hyun,Baek, Moon-Chang SAGE Publications 2013 International journal of toxicology Vol.32 No.5
<P>Mercury is a well-recognized health hazard and a deleterious environmental contaminant. Exposure to mercury can cause neurotoxic manifestations, nephrotoxicity, and immune function alterations; however, the mechanisms and related proteins responsible for these effects are still unclear. Our goal is to understand the relationship between the toxicity of mercury and the proteins affected by this toxic heavy metal and to define biomarkers for mercury intoxication. Two different forms of mercury, organic methylmercury or inorganic mercury sulfide, were orally administered to the mice for 4 weeks. To reduce complexity of the serum proteome, we enriched glycoproteins from mice serum with lectin concanavalin A resin, and the tryptic peptides of the purified glycoproteins were subjected to nanoultra performance liquid chromatography-Quadrupole time-of-flight for identification and label-free quantification. In this study, we characterized approximately 209 proteins from mice serum, and, among them, 21 proteins were differentially expressed in organic methylmercury-treated mice serum compared with the control group. Two proteins, serum amyloid P component (SAP) and inter α-trypsin inhibitor heavy chain 4 (ITI-H4), were upregulated in organic methylmercury-treated mice and confirmed with different doses of both types of mercury by Western blot analysis. Results of immunohistochemistry also confirmed the validity of SAP and ITI-H4 as biomarker candidates for organic methylmercury exposure. Findings of this study may assist in understanding the relationship between toxicity of mercury and upregulated proteins in mouse serum. Furthermore, the proteins identified here might be used as biomarker candidates in mercury intoxication.</P>
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Lee, Eun-Jung,Woo, Moon-Sook,Moon, Pyong-Gon,Baek, Moon-Chang,Choi, In-Young,Kim, Won-Ki,Junn, Eunsung,Kim, Hee-Sun Williams Wilkins 2010 JOURNAL OF IMMUNOLOGY Vol.185 No.1
<P>The mutation or overexpression of alpha-synuclein protein plays a pivotal role in the pathogenesis of Parkinson's disease. In our preliminary experiments, we found that alpha-synuclein induced the expression of matrix metalloproteinases (MMPs) (MMP-1, -3, -8, and -9) in rat primary cultured microglia. Thus, the current study was undertaken to determine the roles of MMPs in alpha-synuclein-induced microglial activation. The inhibition of MMP-3, -8, or -9 significantly reduced NO and reactive oxygen species levels and suppressed the expression of TNF-alpha and IL-1beta. Notably, MMP-8 inhibitor suppressed TNF-alpha production more efficaciously than MMP-3 or MMP-9 inhibitors. Inhibition of MMP-3 or -9 also suppressed the activities of MAPK, NF-kappaB, and AP-1. Previously, protease-activated receptor-1 (PAR-1) has been associated with the actions of MMPs, and thus, we further investigated the role of PAR-1 in alpha-synuclein-induced inflammatory reactions. A PAR-1-specific inhibitor and a PAR-1 antagonist significantly suppressed cytokine levels, and NO and reactive oxygen species production in alpha-synuclein-treated microglia. Subsequent PAR-1 cleavage assay revealed that MMP-3, -8, and -9, but not alpha-synuclein, cleaved the synthetic peptide containing conventional PAR-1 cleavage sites. These results suggest that MMPs secreted by alpha-synuclein-stimulated microglia activate PAR-1 and amplify microglial inflammatory signals in an autocrine or paracrine manner. Furthermore, our findings suggest that modulation of the activities of MMPs and/or PAR-1 may provide a new therapeutic strategy for Parkinson's disease.</P>
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김준평,오문헌 中央大學校 遺傳工學硏究所 1991 遺傳工學硏究論集 Vol.4 No.1
β-Amylase (α-1, 4-D-glucan maltohydrolase, EC 3.2.1.2) was isolated and purified from wheat(Triticum aestivum var. Gerumil) produced in Korea. The homogeneity of β-amylase was examined by polyacrylamide disc gel electrophoresis(PAGE), Wheat β-amylase was purified by using the methods of ammonium sulfate fractionation, ion-exchange chromatography on DEAE-cellulose, calcium phosphate gel absorption, Sephadex G-100 gel filtration, hydroxyapatite column chromatography. The enzyme was futher fractionated into three fractions A, B and C by hydroxyapatite column chromatography. The two major fractions A and C showed 37.9 and 33.1 times higher activity than crude enzyme, respectively, and the specific activity was found to be 246.1 and 215.2 unit/mg, respectively. The molecular weight of β-amylase was determined by SDS electrophoresis and it was found to be 54,500 daltons. The isoelectric points of fractions A and C were 4.96 and 4.61, respectively. The N-terminal amino acids of the fractions A and C determined by DABITC's method were glycine. The fractions A and C of wheat β-amylase were estimated to have 512 and 516 amino acid residues/mole, respectively. The activity of wheat β-amylase was decreased by ??, ??, ?? and ?? ions, whereas it was increased by ?? and ?? ions. Km values of the fractions A and C of wheat β-amylase for soluble starch were 0.19 and 0.56%, respectively, indicating high affinity between fraction A and substrate. Optimum temperature and pH for the fractions A and C of wheat β-amylase were 50℃ and 6.0. and both the fractions were stable at 0-60℃ anc at pH 4.5-7.5.
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치주 질환 심도와 치은열구액내 β-glucuronidase에 관한 연구
문진균,김평환,김형섭 全北大學校 齒醫學硏究所 1990 전북치대논문집 Vol.8 No.1
Because traditional clinical measures of human periodontal disease cannot be detected or predicted the occurance of clinical attachment loss, new biochemical workers were developed in diagnosis of periodontal disease. β-glucuronidase, for such a marker associated with tissue breakdown, was analysed from gingival crevicular fluid of 101 periodontal patients aged 27-62 years. The filter paper strip was inserted into the gingival sulcus of the labial surface of the maxillary left central incisor and gingival crevicular fluid colleted. By the modification of the method of Dingle (9172), β-glucuronidase was assayed spectrophotometrically from supernatant enzyme preparation, and compared with clinical parameters such as pocket depth or sulcus bleeding index. 1. As the grade of sulcus bleeding index was increased, the periotron units and β-glucuronidase activity were increased significant(P<0.05). 2. Correlation between SBI and β-glucuronidase, SBI and periotron units, periotron units and β-glucuronidase were relatively low. Those correlation between periotron units and β-glucuronidase was the highest (γ=0.34). 3. As the grade or pocket depth was increased, periotron units and β-glucuronidase were not increased significantly(P>0.05).
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김준평,손태화,석호문,남영중,윤형식,박용곤 한국농화학회 1988 Applied Biological Chemistry (Appl Biol Chem) Vol.31 No.4
Physicochemical properties of starch isolated from the naked barley seeds during germination were investigated, The germinated barley seeds showed an apparent increase in amylose component of the starches, and water binding capacities of the starches decreased initially and then increased with longer germination time. The size frequency distribution of starch granules showed that the granules larger than 20.2μ in diameter were preferentially degraded, and moreover the rate of degradation was higher than that of granules of any other size. It was apparent that the mean diameter of granules was 12.7∼20.2μ at all stages of germination. The results of differential scanning calorimetry, swelling power, solubility and X-ray diffraction patterns of starch granules isolated at various stages of germination showed little changes during germination. Scanning electron microscopy revealed that the starch granules have been damaged extensively by degradative enzymes during germination, but all the starch granules were not degraded uniformly.
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