Kainic acid 를 사용한 소뇌피질 단소엽의 손상이 고전적 순막조건화에 미치는 효과

문양호,김기석 한국심리학회 1989 한국심리학회지 생물 및 생리 Vol.1 No.1

본 연구는 소뇌피질 단소엽의 손상이 고전적 순막조건화에 미치는 영향을 검증하기 위한 것이다. 소뇌피질 단소엽이 순막조건화에 필수적인 신경 구조물인가를 확인하고, 또한 순막조건화와 관련된 필수적인 기억흔적이 형성되는 신경가소성이 일어나는 부위인가를 규명하고자 하였다. 이를 위하여 토끼를 대상으로 순막조건화를 실시한 후 소뇌피질 단소엽을 파괴하였으며, 이어서 이전에 확립된 조건반응의 파지 및 재학습 여부, 그리고 전이효과를 검사하였다. 소뇌피질 단소엽의 손상은 신경섬유의 역행성 변성으로 인한 문제를 해결하고자 세포체만을 선택적으로 손상시키는 Kainic acid을 미세주입하였다. 실험결과, 소뇌피질 단소엽이 완전히 손상된 집단은 손상전에 확립된 순막 조건반응의 파지 및 재학습이 불가능하였으나 무조건반응은 영향받지 않았다. 한편, 단소엽이 아닌 다른 소엽에 동일한 양의 Kainic acid에 의한 손상을 받은 통제집단은 이전에 확립된 조건반응이 존속되었다. 이와같은 본 연구의 결과는 소뇌피질 단소엽이 순막조건화에 결정적인 신경구조물임을 밝힌 이전의 연구결과들과 일치하며, 조건화 동안에 기억흔적과 관련된 신경가소성이 소뇌피질 단소엽에서 일어난다는 가설을 지지한다. The present experiment purports to examine effects of the cerebellar cortical simple lobule(HVI) on the classical conditioning of rabbit's nictitating membrane responses(NMR). The study examined whether the lobule HVI is an essential structure for NMR conditioning and whether it is the localized site where the critical memory trace related to classical NMR conditioning is formed. Many of the previous studies which explored the function of the lobule HVI in the MNR neural circuit have employed aspiration lesion techniques. But the aspiration may also damage inferior olive, pontine nuclus and deep cerebellar nucleus by retrograde degenerations of neural fibers as well as the simple lobule. In this study, kainic acid was micro-injected into the lobule HVI in order to overcome such porblems because the kainic acid destroys selectively the cell bodies and leave the fibers intact. Subjects were 16 rabbits. All animals were trained using standard procedures for NMR conditioning. The conditioning involves a tone(1㎑, 85㏈ SPL, 350㎳) as the conditioned stimulus(CS) with a coterminating periorbital electric shock(3㎃, 100㎳) delivered at the right eye as the unconditioned stimulus(US). Following the conditioning, the simple lobule of the right side cerebellum was lesioned. After recovery, animals received 5 days training on the right side to test for retention and reacquisition of conditioned responses. Then, animals received an additional session in which training was switched to the left side. Results show that complete lesions of the lobule HVI abolished previously established conditioning and prevented subsequent reacqusition, while unconditioned responses to US were intact. Lesions of the other cerebellar lobules did not impair the conditioning. The results suggested that the simple lobule is an essential part for classical NMR conditioning and that neural plasticity related to memory trace during the conditioning occurs in the simple lobule rather than in the dentate-interpositus nucleus.

大學校 敎職員의 健康實態에 관한 基礎的 調査硏究

양점홍,황철문,남태호,백영호,윤양진,황영성 부산대학교 사범대학 1993 교사교육연구 Vol.26 No.-

The purpose of this study was to analyze the staffs' health of P. University through survey research. Also, the staffs's health problem was analyzed by the regular health test's result and their lifestyle. The results were as following: 1. The analysis of lifestyle (1) A habit of smoking 1. It was presented the male smokers(55.9%) and females smokers(0.6%) of P. university staffs were found in this study. 2. It was presented the male smokers smoked average 18.2 pieces a day. Also, they began to smoke cigarette 21.5 years old. 3. The persistent smokers were 24.6% and 52.2% of smokers be going to quit smoking cigarette someday in the future. (2) A habit of drinking 1. It was presented 85.7% of males and 59.1% of females subject drinking normally. 2. It was presented 3.7% of male subjects were drinking alcohol almost everyday in a week. 3. The most frequent kind of alcohol is as following order a beer(males 67.6% & females 79.6%) and a soju(males 28.3% & females 4.3%). Males drunken average amount of beer was 2 bottles(640ml) and females drunken average amount of beer was 0.8 bottles in a week. (3) A habit of exercise 1. It was presented males (29.0%) and females (15.1%) were exercising regularly, but males (23.3%) and females (38.6%) of staffs were not exercise at all. 2. It was found males' regular kind of exercise was as following order mountain-climbing, tennis, and jogging and females' regular kind of exercise was as order swimming, free handing exercise, and mountain-climbing. 3. It was presented 25.1% of staffs exercised 6 times a week regularly. And each times of exercise, 37.3% of staffs spent less than 30 minutes. 4. It was presented staffs exercised for health (72.4%) and 48.4% of staffs could not exercise as following reasons of not enough times, home work, research.... 5. Male staffs prefer as following order kind of sport tennis, swimming, and golf and female staffs prefer as following order kind of sport swimming, tennis, and bowling in the future. (4) A habit of eating 1. It was presented 5.5% of males and 16.6% of females did not have a breakfast regularly. 2. Concerning balance of food content: do not concerning food (males 34.7% & females 23.8%) and subjects like vegetables 9males 25.7% & females 32.7%) were found. 3. It was presented 8.5% of males and 5.4% of females took the vitamin regularly. (5) Health condition 1. In present evaluation for subject's health condition, very healthy (males 7.5% & females 6.0%) and poor health (males 2.0% & females 1.8%) were found in this study. 2. In present evaluation criterion for subject's health condition, the ability of adaptation on fatigue was appeared the most (males 35.9% & females 40.7%). 3. It was presented subjects have a digestive trouble (males 23.5% & females 33.1%) which were the best health problem in subjects. 2. A analysis of result of regular health test (1) Physique test 1. It was presented height (males 169.5cm & females 158.6cm) and body weight (males 65.9kg & females 53.1kg) were found in this study. 2. According to this study, obesity (males 11.2% & females 5.6%) and low body weight (males 8.8% & females 14.8%) were found in this study. 3. A high blood pressure subject (males 8.7% & females 2.5%) over than a contraction blood pressure 140mmHg and A high blood pressure subject (males 8.5% & females 1.9%) over than a expansion blood pressure 90mmHg were found in this study. (2) A blood test 1. Normal hemoglobin of subject (males 99.8% & females 62.3%) and 37.7% of females less than normal hemoglobin were found in this study. 2. 5.3% of males and 2.5% of females have greater than a concentration of glucose 140mg/dl, but there was anyone less than a concentration of glucose 50mg/dl. 3. The greater than 251mg/dl staff''s T.C.(males 7.1% & females 4.9%) and the less than 130mg/dl staffs' T.C.(males 2.0% & females 3.7%) were found in this study. 4. It was found males 5.3%, 11.6% & females 1.9%, 4.3% were presented greater than GOT and GPT 341U/L. (3) Hepatitis, Urinary Sugar, and Urinary Protein test 1. According to this study result, positive hepatitis was presented males (6.5%) and female(4.3%). 2. Urinary sugar is greater than +- males (1.8%) and females (2.4%) were found in this study. 3. Urinary protein is greater than +- males (1.6%) and females (1.8%) were found in this study. (4) Chest X-ray test 1. It was found male (1.6%) suffered from tuberculosis of the lungs. (5) Dental test 1. It was presented 77.3% of males and 88.9% of females was not existed the upper caries. Also, 75.7% of males and 90.7% of females was not existed the bottom caries. 2. It was presented 96.8% of males and 99.4% of females had the non-deficit of teeth in the upper part of teeth. Also, 93.9% of males and 98.1% of females had the non-deficit of teeth in the bottom part of teeth. 3. It was presented 19% of males and 3.7% of females have the periodontal disease. (6) General report and judgment 1. In general report, it was found 75.3% of males and 91.4% of females were the normal health condition. It was presented 9.1% of males and 4.9% of females were the liver disease, 4.9% of males and 1.2% of females were the sugar diabetes, 4.9% of males and 0.6% of females were the high blood pressure, and 1.4% of males and 1.9% of females were high arrest of bleeding. 2. In general judgment, it was presented 75.5% of males and 91.4% of females were the normal health condition. However, it was presented 17.8% of males and 7.4% of females were required high observation, 6.7% of males and 1.2% of females were required simple observation. As presented P. University staffs' lifestyle, it was found still many staffs have not right living habit. It is necessary to be wellness of lifestyle and satisfaction of life through correction of self responsibility and management in their life. Therefore, it is possible to live with healthy in better quality of life which is high quality of life and new concept of health were offered. Also, researcher expected the regular health examination be more practical contents than informal contents. Researcher recommended that it is necessary to support the university administration to be more flexibility of the regular health examination day than set the certain day of regular health examination and it required to create a way of using the P. university hospital.

방사선 측정 및 해석 연구 : 원자로 냉각수중의 방사능해석에 의한 결함핵연료봉의 평가 Assessment of Defected Fuel by Analysis of Reactor Coolant Activities

양재춘,오희필,전재식,이호연,오헌진,정문규,박해용 충남대학교 기초과학연구소 1987 연구논문집 Vol.7 No.-

중성자와 우라늄의 핵반응에 의해 생성된 핵분열생성물의 물리적 특성을 이용하여 원자로 내의 핵연료 상태를 해석하는 모델을 개선하였다. 이 모델에서는 고체 핵연료 내에서 특정핵종의 핵분열생성물의 생성과 이것이 원자로 냉각재까지 방출되는 과정을 계산하고 추적하여 방사능농도와 결함 핵연료봉의 수를 관계짓는 방정식의 계수들을 결정한다. 핵분열생성물의 거동은 이탈(knock out)과 이동(migration) 두 부분으로 나누어 해석하였으며 트램프 우라늄의 영향을 분리할 수 있도록 하였다. 실측자료로는 가압 경수형 원자로인 고리 원자력발전소 1호기의 1차 냉각재를 분석해서 얻은 I-131과 I-133의 방사능 강도를 이용하였다. 이 실험자료와 위 방정식에서 구한 방사능 강도로부터 구한 결함 핵연료의 수는 제3주기에서 9.34±1.13개 제6주기에서 0.294±0.092개로 나타났다. An improved mothod of assessing fuel status by analyzsis of the fission product in the reactor coolant system is proposed. The release mechanism of specific fission products is established for determination of the coefficients in the equations which relate the radioactivities with the amount of detected fuel. Knock-out and migration models are employed in the formulation of the release mechanism. The influence of the tramp uranium is quantified. Sample calculations were made for KNU 1 reactor system using the I-131 and I-133 concentrations in the primary coolant. The estimated number of defected fuel pins in the third and sixth cycles appeared to be 9.34±1.13 and 0.294±0.092, respectively.

TiO₂에 담지된 금속 산화물 촉매상에서 TCE 산화분해반응

양원호,김문현 한국환경과학회 2006 한국환경과학회지 Vol.15 No.3

敗令散 및 補中治濕湯이 Puromycin Aminonucleoside로 誘發된 白鼠의 腎症에 미치는 影響

梁文浩,曺東鉉,安世永,鄭定烈,杜鎬京 慶熙大學校韓醫科大學韓醫學硏究所 1995 慶熙韓醫大論文集 Vol.18 No.2

The effects of Paeryungsan and Bojungchiseubtang on rats with nephrosis induced by a single intravenous injection of puromycin aminonucleoside(PAN), 2.5mg/100g of body weight were evaluated in the present study. The effects of Paeryungsan and Bojungchiseubtang on PAN nephrosis were evaluated by measuring ①the concentrations of albumin, total protein, total lipid, cholesterol, triglyceride, creatinine, blood urea nitrogen and uric acid in the serum, ②the amount of volume, protein, glucose and creatinine of the 24hours urine ③the concentration of blood in the urine, intake water, and by observing the changes of microscopic findings of kidney. The results are summerized as follows; 1. In the control group, the concentrations of cholesterol, creatinine, blood urea nitrogen in the serum, the amount of protein and glucose of 24 hours urine, creatinine of 24 hours urine and 24 hours urine volume on the 22th day were significantly increased. On the other hand, the concentration of albumin in the serum, the amount of creatinine of 24 hours urine on the 8th day, the volume of 24 hours urine and the intake water on the 8th, 15th day were decreased significantly. Electron microscopic findings were the segmental obliteration of the foot processes, swelling and villous transformations of the visceral epithelial cells and partial increase of the mesangial matrix. 2. In Paeryungsan group, the decrease of albumin in the serum and intake water were inhibited significantly. But the increase of the concentrations of cholesterol and blood urea nitrogen in the serum were inhibited significantly. And the amount of creatinine of 24 hours urine was increased significantly. There was no significant difference between Paeryungsan group and the control group in electron microscopic findings. 3. In Bojungchiseubtang group, the decrease of albumin in the serum and intake water were inhibited significantly. But the increase of the concentrations of cholesterol, total lipid, creatinine, blood urea nitrogen in the serum and the amount of protein in the 24 hours urine were inhibited significantly. The concentration of protein in the serum was increased significantly. There was no significant difference between Bojungchiseubtang group and the control group in electron microscopic findings. To conclude, PAN nephrosis was induced by a single intravenous injection of PAN 2.5mg/100g of body weight on rats. It can be inferred that Paeryungsan group has the effects of improving hypoalbuminemia in nephrotic syndrome and relieving azotemia when nephrotic syndrome is accompanied by the acute renal failure. It can be inferred that Bojungchiseubtang may improve proteinuria, hypoalbuminenia, hyperlipidemia in nephrotic syndrome. But there was no significant difference between Paeryungsan and the control group, between Bojungchiseubtang group and the control group in electron microscopic findings. So I hope that there will be further studies on the effect on the alterations of glomerular polyanion sites, and on the functioning mechanism of Paeryungsan and Bojungchiseubtang in the future.

핵연료에서 핵분열 생성물의 방출 기구에 관한 연구

양재춘,이호연,정문규 충남대학교 기초과학연구소 1986 연구논문집 Vol.6 No.-

중성자와 우라늄의 핵 반응에 의해 생성된 핵분열 생성물의 물리적 특성을 이용하여 원자로 내의 핵연료 상태를 해석하는 새로운 모델을 도입하였다. 고체 핵연료 내에서 핵분열 생성물의 생성과 이것의 원자로 냉각재까지 방출되는 과정을 계산하는 방정식을 세웠다. 이 방정식으로 핵분열 생성물의 source term을 계산하고, 이것이 고체 핵연료 내에서 방출되어 gap과 핵연료 피복재를 통하여 원자로 냉각재까지 방출하는 양을 계산하였으며, 원자로 1차 냉각재에서의 tramp uranium양을 계산하였다. 이 방정식을 computer로 계산하기 위하여 전산화 하였다. 실험 자료로는 가압 수형 원자로 (Pressurized Water Reactor)인 고리 원자력 발전소 1호기의 제 3주기 동안에 핵연료의 상태를 감시하기 위해 1차 냉각재를 분석해서 얻은 핵분열 생성물의 방사능 강도를 이용하였다. 이 실험 자료와 위 방정식에서 계산한 방사능 강도를 비교하여 결함 핵연료 수와 tramp uranium 양을 구하였다. 이렇게 구한 결과와 고리 1호기의 제 3주기 말에 핵연료 재장진을 위해 수행한 sipping test 결과를 비교해 보았다. 그 결과 본 연구에서 도입한 모델이 잘 맞는 것을 알 수 있었다. We propose the new model which analyzes the nuclear fuel state of the reactor from the physical characteristics of nuclear fission products which are produced by reactions between neutron and uranium 235. The main feature of this model is to calculate the generation of fission products inside the solid nuclear fuel and the release mechanism of fission products into the reactor coolant. Using the computer we solved the equation of the model and put the experimental activity data of the fission products to determine the number of failed fuel rods and amount of tramp uranium. These data had been taken from the primary coolant of the Kori Nuclear Generating Station, Unit 1. This result of our calculation is in a fairly good agreement with the result of the sipping test during the refueling period for cycle 3 of the Kori Nuclear Generating Station, Unit 1. As a result of this research we conclude that our model for the release mechanism of unclear fission products in reactor fuel is well describing the actual processes.

시계열 스트림 시퀀스 매칭을 위한 효율적인 내장형 알고리즘

문양세,김진호 강원대학교 정보통신연구소 2006 정보통신논문지 Vol.10 No.-

For handheld devices, minimization of CPU operations is the most important factor in performance. In this paper, we propose the efficient algorithms that extract sequences similar to the given query sequence from the time-series stream sequence matching as the problem of finding similar to the given query sequence from the time-series stream such as network traffic data, stock prices, and sensor data. First, we formally define th stream sequence matching as the problem of finding similar sequences from the time-series stream. Second, we propose an efficient window-based approach by using the window construction mechanism of traditional subsequence matching methods. Third, we provide the notion of window MBR and propose two different stream sequence matching algorithms based on the notion. Fourth, we formally prove correctness of the proposed algorithms by presenting related theorems. Last, through extensive experiments, we show that our approach improves performance significantly compared with the naive approach. Overall, we believe that our methods would be very suitable for handheld devices as the embedded algorithms.

韓國人血液群 A,B,및 AB 赤血球의 被疑集性에 關한 硏究

梁學道,李楨浩,尹秉文,芮薰海,全東雨,李文玉,金晉郁 醫藥係社 1955 綜合 醫學 Vol.12 No.8

음식점 비흡연 종업원의 간접흡연 노출량 지표로써 이산화질소 이용

양원호,고영림,한인규,이정민,정문식,정문호 대한위생학회 2000 대한환경위생공학회지 Vol.15 No.3

There, is increasing evidence suggesting that passive smoking increases the risk of lung cancer and other disease. though the potential health effects of exposure to environmental tobacco smoke (ETS) is a controversial subject. Since smoking in restaurant is prevalent in Korea. The concern on passive smoking exposure of non smoking service workers has been. requested. ETS exposure of non smoking service workers at restaurant was assessed because they have spent their times in restaurant indoors. The purpose of this study was feasibility of nitrogen dioxide(NO_(2))as exposure marker of ETS. The results of the study were as follows: 1. Average NO_(2), concentrations in indoor and outdoor at restaurants were 57.01ppb(±12.4) and 54.29ppb(±9.54), respectively. Comparing office-workers, service-workers at restaurants were exposured highly. 2. The personal NO_(2) measurement as exposure marker of ETS could cause The exposure error because NO_(2) can he generated by combustion appliances in indoor. 3. Service-workers spent their most time (86.6%) in indoor. Mean time spent at restaurant indoors and at home was 9.4 hours and 10.9 hours. respectively. 4. Personal NO_(2) levels correlated with indoor NO_(2) concentrations of restaurant (r=0.70) and of their home (r= 0.52) rather than of outdoor NO_(2) concentration of restaurant (r=0.35). The causes of personal NO_(2) exposure of non-smoking service-workers were considered as smoking of guests and combustion appliance indoors. 5. Personal NO_(2) exposures were estimated using Monte-Carlo simulation and time-weighted model. Estimated personal NO_(2) level was 47.2ppb (±8.3).

방사선 측정 및 해석 연구 : Assessment of Defected Feul by Analysis of Reactor Coolant Activities 원자로 냉각수중의 방사능해석에 의한 결합핵연료봉의 평가

이호연,오헌진,전재식,오희필,양재춘,정문규,박해용 대한방사선 방어학회 1986 방사선방어학회지 Vol.11 No.2

중성자와 우라늄의 핵반응에 의해 생성된 핵분열생성물의 물리적 특성을 이용하여 원자로 내의 핵연료 상태를 해석하는 모델을 개선하였다. 이 모델에서는 고체 핵연료 내에서 특정핵종의 핵분열 생성물의 생성과 이것이 원자로 냉각재까지 방출되는 과정을 계산하고 추적하며 방사능농도와 결합핵연료봉의 수를 관계짓는 방정식의 계수들을 결정한다. 핵분열생성물의 거동은 이탈(knock out)과 이동(migration) 두 부분으로 나누어 해석하였으며 트램프 우라늄의 영향을 분리할 수 있도록 하였다. 실측자료로는 가압 경수형 원자로인 고리 원자력발전소 1호기의 1차 냉각제를 분석해서 얻은 I-131과 I-133의 방사능 강도를 이용하였다. 이 실험자료와 위 방정식에서 구한 방사능 강도로부터 구한 결함 핵연료의 수는 제3주기에서 9.34±1.13개 제6주기에서 0.294±0.092개로 나타났다. An improved method of assessing fuel status by analysis of the fission product in the reactor coolant system is proposed. The release mechanism of specific fission products is established for determination of the coefficients in the equations which relate the radioactivities with the amount of defected fuel. Knock-out and migration models are employed in the formulation of the release mechanism. The influence of the tramp uranium is quantified. Sample calculations were made for KNU 1 reactor system using the I-131 and I-133 concentrations in the primary coolant. The estimated number of defected fuel pins in the third and sixth cycles appeared to be 9.34±1.13 and 0.294±0.092, respectively.