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Byun, Sung-Hyun,Kwon, Mookwang,Lee, Sun Min,Noh, Hogyun,Yoon, Keejung Academic Press 2019 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>The protein activator of protein kinase R (PKR) (PACT) is known to play important roles in PKR regulation and microRNA biogenesis. Based on the observation that PACT is specifically expressed in the ventricular zone (VZ) at the mid-neurogenic period, we examine the role of PACT in this embryonic neural stem cell niche. Here, we provide the first evidence that PACT increases neurosphere formation, as well as expression of Notch target genes and the neural stem cell marker Sox2 in primary neural stem cells <I>in vitro</I>. Consistently, introduction of PACT into the mouse embryonic brain <I>in utero</I> increased the fraction of cells localizing to the VZ. We also show that the PACT-enhanced stemness of neural stem cells is PKR-independent. At the molecular level, PACT was revealed to physically interact with C promoter binding factor 1 (CBF1) and dramatically strengthen the association between CBF1 and Notch intracellular domain (NICD), which indicates stabilization of the Notch transcriptional coactivation complex responsible for Notch target gene expression. Taken together, our study indicates that PACT is a novel transcriptional coactivator of the Notch pathway playing a pivotal role during mammalian brain development.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PACT enhances mammalian embryonic neural stem cell properties as assessed <I>in vitro</I> and <I>in vivo.</I> </LI> <LI> PACT-increased neural stemness is independent of PKR. </LI> <LI> PACT augments the Notch signaling pathway, a master regulator of neural stem cell fate, at the transcriptional level. </LI> <LI> PACT stabilizes the Notch coactivational complex by enhancing association between NICD and CBF1. </LI> </UL> </P>
Production of Urban Debris Flow Hazard Maps: Case study in Daegu, Korea
Yoonkyung Park,Mookwang Sung,Wooyoung Cha,Sangdan Kim 한국방재학회 2017 Journal of Disaster Management Vol.2 No.1
Abstract : This study is classified as a possible indirect and direct damage caused by landslides in Daegu and produces urban debris flow hazard maps. The range of urban debris flow is identified in the spatial scale of census output areas using Flow-R forced by landslide hazard maps. After dividing the type of building in each census output area into two (reinforced concrete structures and non-reinforced concrete structures), the physical hazard is assessed in applying the corresponding vulnerability function. An index-based model is proposed to represent indirect damages, using this model application, the socioeconomic hazard is also assessed. The urban debris flow hazard is finally assessed by integrating two hazard assessments. The assessment maps produced in this study can be used in identifying debris flow risk regions in the Daegu metropolitan and are expected to serve as basic data to prepare debris flow protection facilities. Abstract : This study is classified as a possible indirect and direct damage caused by landslides in Daegu and produces urban debris flow hazard maps. The range of urban debris flow is identified in the spatial scale of census output areas using Flow-R forced by landslide hazard maps. After dividing the type of building in each census output area into two (reinforced concrete structures and non-reinforced concrete structures), the physical hazard is assessed in applying the corresponding vulnerability function. An index-based model is proposed to represent indirect damages, using this model application, the socioeconomic hazard is also assessed. The urban debris flow hazard is finally assessed by integrating two hazard assessments. The assessment maps produced in this study can be used in identifying debris flow risk regions in the Daegu metropolitan and are expected to serve as basic data to prepare debris flow protection facilities.
Jang, Jiwon,Byun, Sung-Hyun,Han, Dasol,Lee, Junsub,Kim, Juwan,Lee, Nayeon,Kim, Inhee,Park, Soojeong,Ha, Soobong,Kwon, Mookwang,Ahn, Jyhyun,Chung, Woo-Jae,Kweon, Dae-Hyuk,Cho, Jae Youl,Kim, Sunyoung,Yo Mary Ann Liebert 2014 STEM CELLS AND DEVELOPMENT Vol.23 No.23
<P>Notch has a broad range of regulatory functions in many developmental processes, including hematopoiesis, neurogenesis, and angiogenesis. Notch has several key functional regions such as the RBP-Jκ/CBF1 association module (RAM) domain, nuclear localization signals (NLS), and ankyrin (ANK) repeats. However, previous reports assessing the level of importance of these domains in the Notch signaling pathway are controversial. In this study, we have assessed the level of contribution of each Notch domain to the regulation of mammalian neural stem cells in vivo as well as in vitro. Reporter assays and real-time polymerase chain reactions show that the ANK repeats and RAM domain are indispensable to the transactivation of Notch target genes, whereas a nuclear export signal (NES)-fused Notch intracellular domain (NICD) mutant defective in nuclear localization exerts a level of activity comparable to unmodified NICD. Transactivational ability appears to be tightly coupled to Notch functions during brain development. Unlike ANK repeats and RAM domain deletion mutants, NES-NICD recapitulates NICD features such as promotion of astrogenesis at the expense of neurogenesis in vitro and enhancement of neural stem cell character in vivo. Our data support the previous observation that intranuclear localization is not essential to the oncogenesis of Notch1 in certain types of cells and imply the importance of the noncanonical Notch signaling pathway in the regulation of mammalian neural stem cells.</P>