Review of Cohort Studies for Mood Disorders

Hong Jin Jeon,Ji Hyun Baek,Yong Min Ahn,김세주,Tae Hyun Ha,Bo-Seok Cha,Eun Soo Moon,강희주,Vin Ryu,조철현,Jung-Yoon Heo,Ki-Won Kim,Heon-Jeong Lee,Mood Disorders Cohort Research Consortium 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.3

This paper aimed to review currently available cohort studies of subjects with mood disorders such as major depressive disorder (MDD) and bipolar disorder (BD). Using the PubMed and KoreaMed databases, we reviewed eight major cohort studies. Most studies recruited participants with MDD and BD separately, so direct comparison of factors associated with diagnostic changes was difficult. Regular and frequent follow-up evaluations utilizing objective mood ratings and standardized evaluation methods in a naturalistic fashion are necessary to determine detailed clinical courses of mood disorders. Further, biological samples should also be collected to incorporate clinical findings in the development of new diagnostic and therapeutic approaches. An innovative cohort study that can serve as a platform for translational research for treatment and prevention of mood disorders is critical in determining clinical, psychosocial, neurobiological and genetic factors associated with long-term courses and consequences of mood disorders in Korean patients.

승강장 스크린도어의 유한 요소해석을 통한 피로하중 안전성 검토

최문덕(Mood-duck Choi),조종두(Chon-gdu Cho),최원준(Won-june Choi),김정엽(Jung-yup Kim) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5

Subway railway systems are being increasingly adopted in metro cities to ease the passenger transportation. But there are some concerns related to the safety of the passengers. Nowadays, PSD(Platform Screen Doors) are commonly used to assure the safety of passengers. PSD is used to prevent the fire disasters, air turbulence, and dust which may pose a threat to the passenger's safety. Moreover the design of PSD itself has to take some parameters into consideration, crowd loading, wind pressure, etc. In our present study we perform a fatigue analysis considering these parameters. Commercial finite element software package ANSYS Workbench 11.0 has been used for the structural analysis. In correlation with this analysis, the structural safety of the testing PSD equipment was confirmed, and the critical load condition was found.

플랜트 모듈의 변형 및 상태감지 시스템 개발

문수진(Soojin, Mood),오민균(Mingyun Oh),정진우(Jinwoo, Jung),나영우(Youngwoo Na) 대한토목학회 2019 대한토목학회 학술대회 Vol.2019 No.10

A Study on the Relationship between Online Community Characteristics and Loyalty Focused on Mediating Roles of Self-Congruency, Consumer Experience, and Consumer to Consumer Interactivity

김문태(Kim, Mood-Tae),옥정원(Jung-Won Ock) 한국마케팅과학회 2008 마케팅과학연구 Vol.18 No.4

온라인 커뮤니티에 대한 연구는 학자들과 실무자들의 많은 관심을 받아온 분야이다. 과거 많은 연구자들이 온라인 커뮤니티를 통해 큰 상업적 성과를 거둘 수 있다고 했지만 현실은 그렇지 못하며 마케팅 연구 분야에서도 상업적 성공을 이끄는 변수들에 대한 연구가 많이 이루어지지 못한 것이 사실이다. 이러한 점에서 본 연구는 온라인 커뮤니티 사이트들이 콘텐츠 관련 마케팅 노력을 통해 소비자들의 자아일치성을 높이고 긍정적 체험을 유도하면서 커뮤니티 사이트 내에서 소비자 간의 상호작용성 등을 높여 결국 커뮤니티 사이트의 방문충성도 및 구매충성도를 실현시킬 수 있는 프레임 웍을 제시하였다. 연구결과 온라인 커뮤니티 사이트에서 소비자 간 상호작용성이 방문충성도 그리고 특히 구매충성도의 구축에 매우 중요한 요인으로 밝혀졌고 온라인 커뮤니티 사이트에 대한 자아일치성 지각 및 긍정적인 소비자 체험 또한 소비자의 상호작용성 방문충성도 그리고 커뮤니티에 대한 애정에 상당히 중요한 요인임을 알 수 있었다 또한 이러한 매개변수에 주된 영향요소로서 콘텐츠 우수성 사이트 생동감 네비게이션 용이성 고객화 등의 콘텐츠 관련 마케팅 노력의 역할의 중요성을 강조하였다. The popularity of communities on the internet has captured the attention of marketing scholars and practitioners. By adapting to the culture of the internet, however, and providing consumer with the ability to interact with one another in addition to the company, businesses can build new and deeper relationships with customers. The economic potential of online communities has been discussed with much hope in the many popular papers. In contrast to this enthusiastic prognostications, empirical and practical evidence regarding the economic potential of the online community has shown a little different conclusion. To date, even communities with high levels of membership and vibrant social arenas have failed to build financial viability. In this perspective, this study investigates the role of various kinds of influencing factors to online community loyalty and basically suggests the framework that explains the process of building purchase loyalty. Even though the importance of building loyalty in an online environment has been emphasized from the marketing theorists and practitioners, there is no sufficient research conclusion about what is the process of building purchase loyalty and the most powerful factors that influence to it. In the study, the process of building purchase loyalty is divided into three levels, characteristics of community site such as content superiority, site vividness, navigation easiness, and customerization, the mediating variables such as self congruency, consumer experience, and consumer to consumer interactivity, and finally various factors about online community loyalty such as visit loyalty, affect, trust, and purchase loyalty are those things. And the findings of this research are as follows. First, consumer-to consumer interactivity is an important factor to online community purchase loyalty and other loyalty factors. This means, in order to interact with other people more actively, many participants in online community have the willingness to buy some kinds of p개ducts such as music, content, avatar, and etc. From this perspective, marketers of online community have to create some online environments in order that consumers can easily interact with other consumers and m맏 some site environments in order that consumer can feel experience in this site is interesting and self congruency is higher that at other community sites. It has been argued that giving consumers a good experience is vital in cyber space, and websites create an active (rather than passive) customer by their nature. Some researchers have tried to pin down the positive experience, with limited success and less empirical support. Web sites can provide a cognitively stimulating experience for the user. We define the online community experience as playfulness based on the past studies. Playfulness is created by the excitement generated through a website's content and measured using three descriptors. Marketers can promote using and visiting online communities, which deliver a superior web experience, to influence their customers' attitudes and actions, encouraging high involvement with those communities Specially, we suggest that transcendent customer experiences(TCEs) which have aspects of flow and/or peak experience, can generate lasting shifts in beliefs and attitudes including subjective self-transformation and facilitate strong consumer's ties to a online community. And we find that website success is closely related to positive website experiences consumers will spend more time on the site, interacting with other users. As we can see figure 2, visit loyalty and consumer affect toward the online community site didn't directly influence to purchase loyalty. This implies that there may be a little different situations here in online community site compared to online shopping mall studies that show close relations between revisit intention and purchase intention. There are so many alternative sites on web, consu

Increase in the Th1-Cell-Based Immune Response in Healthy Workers Exposed to Low-Dose Radiation - Immune System Status of Radiology Staff

Gholamreza Karimi,Mahdi Balali-Mood,Seyed-Ali Alamdaran,Hassan Badie-Bostan,Elaheh Mohammadi,Adel Ghorani-Azam,Mahmood Sadeghi,Bamdad Riahi-Zanjani 대한약침학회 2017 Journal of pharmacopuncture Vol.20 No.2

Objectives: Radiation is one of the most important sources of free radical (such as reactive oxygen species) production, which plays an essential role in the etiology of over hundred diseases. The aim of the study was to investigate some immune parameters and hematological indices in healthy workers of the Radiology Department, University Hospital of Mashhad, Iran. Methods: The study was performed on 50 healthy workers: 30 radiology staff as the case group and 20 laboratory workers as the control group. The radiation dose received by the radiology staff participating in the study was less than the annual maximum permissible level, 50 millisievert. Hematological parameters, lymphocyte proliferation and cytokine production were studied in both groups. Results: Among healthy radiology workers, the hematological indices did not differ statistically; however, their proliferation indices and IFN-γ levels showed significant increases in parallel with decreases in the IL-4 levels as compared to controls. The immune system of workers exposed to low-dose ionizing radiation was found to be shifted from a Type 2 to a Type 1 response to promote cellular immunity. Conclusion: Based on our data, exposure to low-dose ionizing radiation may decrease the prevalence, frequency, and recurrence of various cancers and infectious diseases because of an increase in Th1-cell-based response, thus leading to more protection of the human body against tumor cells and foreign agents and possibly increased longevity. However, due to high rate of fluoroscopy use for interventional radiology, we suggest continuing research projects on radiation protection and hazards to prevent irreversible damage. As a recommendation, in future studies, radiology staff with a weakened immunity due to high radiation exposure should be considered as good choices to be treated using acupuncture techniques because acupuncture has been demonstrated to enhance the function and the number of immune cells.

Increase in the Th1-Cell-Based Immune Response in Healthy Workers Exposed to Low-Dose Radiation - Immune System Status of Radiology Staff

Karimi, Gholamreza,Balali-Mood, Mahdi,Alamdaran, Seyed-Ali,Badie-Bostan, Hassan,Mohammadi, Elaheh,Ghorani-Azam, Adel,Sadeghi, Mahmood,Riahi-Zanjani, Bamdad KOREAN PHARMACOPUNCTURE INSTITUTE 2017 Journal of pharmacopuncture Vol.20 No.2

Objectives: Radiation is one of the most important sources of free radical (such as reactive oxygen species) production, which plays an essential role in the etiology of over hundred diseases. The aim of the study was to investigate some immune parameters and hematological indices in healthy workers of the Radiology Department, University Hospital of Mashhad, Iran. Methods: The study was performed on 50 healthy workers: 30 radiology staff as the case group and 20 laboratory workers as the control group. The radiation dose received by the radiology staff participating in the study was less than the annual maximum permissible level, 50 millisievert. Hematological parameters, lymphocyte proliferation and cytokine production were studied in both groups. Results: Among healthy radiology workers, the hematological indices did not differ statistically; however, their proliferation indices and $IFN-{\gamma}$ levels showed significant increases in parallel with decreases in the IL-4 levels as compared to controls. The immune system of workers exposed to low-dose ionizing radiation was found to be shifted from a Type 2 to a Type 1 response to promote cellular immunity. Conclusion: Based on our data, exposure to low-dose ionizing radiation may decrease the prevalence, frequency, and recurrence of various cancers and infectious diseases because of an increase in Th1-cell-based response, thus leading to more protection of the human body against tumor cells and foreign agents and possibly increased longevity. However, due to high rate of fluoroscopy use for interventional radiology, we suggest continuing research projects on radiation protection and hazards to prevent irreversible damage. As a recommendation, in future studies, radiology staff with a weakened immunity due to high radiation exposure should be considered as good choices to be treated using acupuncture techniques because acupuncture has been demonstrated to enhance the function and the number of immune cells.

Continuous Generation of Bijel Microparticles, Fibers and Films Using Solvent Transfer-Induced Phase Separation (STRIPS)

Martin F. Haase,Nima Sharifi-Mood,Kathleen J. Stebe,Daeyeon Lee 한국고분자학회 2015 한국고분자학회 학술대회 연구논문 초록집 Vol.2015 No.10

Continuous generation of bijel microparticles, fibers and films using solvent transfer-induced phase separation (STRIPS)

( Martin F. Haase ),( Nima Sharifi Mood ),( Kathleen J. Stebe ),이대연 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0

Bicontinuous interfacially jammed emulsions (Bijels) are novel soft materials with potential applications in areas ranging from healthcare,cosmetics, and food to energy and diverse chemical technologies. However,their fabrication is currently limited to only two pairs of immiscible liquids with narrow temperature windows for their formation. In such systems, typical bicontinuous domain sizes are in the range of tens of micrometers, and fabrication is inefficient due to its batch-wise nature and expensive starting materials. We explore the formation of bijels by mass transfer induced ternary liquid-liquid phase separation. The use of commercially available silica nanoparticles and ionic surfactants allows us to continuously form bijel fibers and membranes with controllable morphologies and domain sizes down to only a few hundreds of nanometers. We study the dependence of fiber morphology on different control parameters such as particle and surfactant concentration.The hierarchical morphology of STRIPS bijels open avenues to new applications such as interfacial catalysis.

Differential Wnt11 Expression Related to Wnt5a in High- and Low-grade Serous Ovarian Cancer: Implications for Migration, Adhesion and Survival

Jannesari-Ladani, Farnaz,Hossein, Ghamartaj,Izadi-Mood, Narges Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

Wnt is a powerful signaling pathway that plays a crucial role in cell fate determination, survival, proliferation and motility during development, in adult tissues and cancer. The aims of the present study were three fold: i) to assess Wnt11 immunoexpression and its possible relationship with Wnt5a in high- and low-grade human serous ovarian cancer (HGSC and LGSC) specimens; ii) to assess Wnt11 expression levels in Wnt5a overexpressing SKOV-3 cells; iii) to reveal the role of Wnt11 in viability, adhesion, migration and invasion of SKOV-3 cells using recombinant human Wnt11 (rhWnt11). Immunohistochemistry revealed a significant difference in Wnt11 expression between HGSC and LGSC groups (p=0.001). Moreover, a positive correlation was observed between Wnt5a and Wnt11 expression in the HGSC (r=0.713, p=0.001), but not the LGSC group. The expression of Wnt11 was decreased by 35% in Wnt5a overexpressing cells (SKOV-3/Wnt5a) compared to mock controls. Similarly Wnt11 expression levels were decreased by 47% in the presence of exogenous Wnt5a compared to untreated cells. In the presence of rhWnt11, 31% increased cell viability (p<0.001) and 21% increased cell adhesion to matrigel (p<0.01) were observed compared to control. Cell migration was increased by 1.6-fold with rhWnt11 as revealed by transwell migration assay (p<0.001). However, 45% decreased cell invasion was observed in the presence of rhWnt11 compared to control (p<0.01). Our results may suggest that differential Wnt11 immunoexpression in HGSC compared to LGSC could play important roles in serous ovarian cancer progression and may be modulated by Wnt5a expression levels.

Decreased Levels of Spleen Tissue CD4+CD25+Foxp3+ Regulatory T Lymphocytes in Mice Exposed to Berberine

Gholamreza Karimi,Mahmoud Mahmoudi,Mahdi Balali-Mood,Maryam Rahnama,Shahrzad Zamani Taghizadeh Rabe,Nafiseh Tabasi,Bamdad Riahi-Zanjani 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.2

The effects of isoquinoline alkaloid berberine (BER) on spleen tissue CD4þCD25þFoxp3þ regulatory T (Treg) cells were evaluated in BALB/c mice. Here, BER was administered daily by intraperitoneal injection at doses of 5 mg/kg and 10 mg/kg for 14 days. Following the exposure, mice spleen cellularities, IL-10 production by splenocytes, and spleen Treg/CD4þ cell profiles were studied in all the test groups of animals. The results showed that a high dose of BER (10 mg/kg) could decrease both the absolute and relative percentages of spleen Treg cells as well as decrease the production of IL-10 by splenocytes in the treated mice (p < 0.05). BER at 5 mg/kg did not appear to affect any of these parameters. Based on the finding here, it would seem that BER has effective immunostimulatory properties, which contradicts the results from other studies indicating immunosuppressive effects of BER. Depending on the doses of BER used, it might have a broad spectrum from immunosuppressive to stimulatory effects. Further studies, including more doses, are required to better evaluate the effects of this natural product. Mechanistic studies are required, particularly in case of redox state of the immune cells, to elucidate and determine how BER functions to impart the toxicity effects demonstrated here and in other studies.