Frequency of K-RAS and N-RAS Gene Mutations in Colorectal Cancers in Southeastern Iran

Naseri, Mohsen,Sebzari, Ahmadreza,Haghighi, Fatemeh,Hajipoor, Fatemeh,Razavi, Fariba Emadian Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

Background: K-RAS and N-RAS gene mutations cause resistance to treatment in patients with colorectal cancer. Based on this, awareness of mutation of these genes is considered a clinically important step towards better diagnosis and appropriate treatment. Materials and Methods: Fifty paraffin-embedded blocks of colorectal cancer were obtained from Imam Reza Hospital of Birjand, Iran. Following DNA extraction, the samples were analyzed for common mutations of exons 2, 3 and 4 of KRAS and NRAS genes using real time PCR and pyrosequencing. Results: According to this study, the prevalence of mutations was respectively 28% (14 out of 50) and 2% (1 out of 50) in KRAS and NRAS genes. All the mutations were observed in patients >50 years old. Conclusions: Mutations were found in both KRAS and NRAS genes in colorectal cancers in Iranian patients. Determining the frequency of these mutations in each geographical region may be necessary to benefit from targeted cancer therapy.

Insights into the Mechanical Properties and Correlation Between Strain Path and Crystallographic Texture of the AA2024 Alloy During Severe Plastic Deformation

Majid Naseri,Mohsen Reihanian,Ahmad Ostovari Moghaddam,Davood Gholami,Mohammad Alvand,Ehsan Borhani,Evgeny Trofimov 대한금속·재료학회 2024 METALS AND MATERIALS International Vol.30 No.2

This study examined mechanical properties of AA2024 alloy and its correlation between strain path and crystallographictexture. Accumulative roll bonding (ARB) and cross accumulative roll bonding (CARB) were used to severely deformAA2024 alloys. Electron backscatter diffraction (EBSD) studies demonstrated that nano/ultrafine grains were formed by thestrain routes after eight cycles. It was also found that the lamellar boundary spacing and the mean boundary spacing were~ 360 ± 10 nm and 845 ± 10 nm after eight ARB cycles. In contrast to the ARB, the CARB specimen had equiaxed microstructurescharacterized by grains with a size of 150 and 100 nm. The CARB processed specimen exhibited a mean misorientationangle of 41.83° and a fraction of high angle grain boundaries of 78%, these values were 34.57° and 67% for ARB treatedspecimen, respectively. It was observed that the evolved texture is greatly affected by the strain paths. The ARB processedspecimen revealed strong Copper {112} <111>, Dillamor {4 4 11} <11 11 8>, S {123} <634>, and Brass {011} <211>components. In contrast, the CARB processed specimen showed major texture with prominent Copper {112} <111>, Brass{011} <211>, Rotated Cube {001} <110>, S {123} <634>, and Goss {011} <100> components. In the CARB specimen, theGoss/Brass texture ratio was intensified and the mechanical properties were superior (tensile strength: 535 MPa, microhardness:182 HV, elongation: 11.9%) compared with the ARB processed specimen (tensile strength: 455 MPa, microhardness:145 HV, elongation: 9.2%). Further, the change in strain path did not significantly affect the intensity of Goss and Cubecomponents, ruling out any further recrystallization tendency.

Effect of In-Service Strengthening on the Axial Load Carrying Capacity of Steel Box Columns

Saeed Erfani,Mohsen Naseri,Vahid Akrami 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.1

To avoid any interruption of service and considering economic issues, strengthening of existing columns usually occurs while the member is under service loads. One of the important issues being neglected in the redesign process of retrofitted columns is the effects of significant axial load existing in the columns. This paper presents a numerical study to investigate the behavior and the ultimate bearing capacity of box shaped steel columns reinforced with continuous welded plates while under load. In the first phase of the study, it is intended to evaluate the variation of results with respect to the existing design relations. For this purpose, the ultimate bearing capacity of un-preloaded models is assumed to be in accordance with the selected design code and the corresponding geometric imperfection for each model is defined using several analyses to reach the values obtained with the design code, for further studies. In the second phase, the magnitude of initial imperfection is set to 1/500 of the studied columns. In both phases, the effect of magnitude of existing preload on ultimate bearing capacity is investigated considering two influential parameters, namely the slenderness ratio of the column and the ratio between cross sectional area of the column and reinforcing plates. Results show that by increasing the preload magnitude, the ultimate bearing capacity of reinforced columns with identical reinforcing plates, decreases. This reduction is more notable for the columns with median slenderness ratios. However, as the magnitude of preload increases, the effect of slenderness ratio on the reduction of ultimate bearing capacity becomes more evident. Also, it is found that by using a fixed imperfection ratio of L/500, even for un-preloaded models the ultimate bearing capacity of the strengthened column will be less than the values calculated as per the selected design code. Finally, an empirical relation is proposed to calculate reduction of ultimate bearing capacity for columns affected from various preload level considering different slenderness ratios.

On the mechanical characteristics of fiber reinforced polymer concrete

Asteris, Panagiotis G.,Naseri, Hamid,Hajihassani, Mohsen,Kharghani, Mehdi,Chalioris, Constantin E. Techno-Press 2021 Advances in concrete construction Vol.12 No.4

Polymer Concrete (PC) is a composite material made by fully replacing the cement hydrate binders of conventional cement concrete with polymer binders or liquid resins. As expected, the physico-mechanical properties of PC concrete are governed by the composition of the PC mixture. The present study aims to examine the effect of the aggregate type and of the addition of steel fibers on the mechanical properties of PC. In particular, two PC concrete mixtures, using granite or silica aggregates, have been developed and the effect of the addition of steel fibers has been investigated. The PC mixtures are characterized by mechanical tests such as the compression test, the flexural test, the splitting tensile test and the estimation of the energy absorption. The results of this study demonstrate a relative superiority, in terms of mechanical properties, of the PC made with granite aggregates as compared to that of the silica aggregate mixture. Moreover, the addition of steel fibers on PC mixtures showed a significant increase of the compressive toughness, of the splitting tensile and of the flexural strength, whereas the Young's modulus and compressive strength showed a slight increase.

Is there any Relationship between Food Habits in the Last Two Decades and Gastric Cancer in North-western Iran?

Somi, Mohammad Hossein,Mousavi, Seyed Mohsen,Naghashi, Shahnaz,Faramarzi, Elnaz,Jafarabadi, Mohammad Asghari,Ghojazade, Morteza,Majidi, Alireza,Alavi, Seyed Ahmad Naseri Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

Purpose: The aims of this case-control study were to assess the correlation between some food habits in the last two decades and gastric cancer in East Azerbaijan of Iran. Materials and Methods: In this hospital based case control study, 616 patients (212 gastric cancer patients, 404 cancer free patients) were recruited. Food habits of patients over the past two decades were assessed with a structured questionnaire. We used conditional logistic regression analysis for estimating crude and adjusted odds ratios (OR) and their respective 95% confidence intervals (95%CI). Results: In this study, over-eating, consumption of high fat milk and yogurt and especial types of cheese increased the risk of gastric cancer (All<0.05). Consumption of such especial cheeses such as Koze and Khiki increased the risk of gastric cancer by 12.6 fold (95% CI:1.99-79.36) and 7.36 fold (95% CI:1.33-40.54), respectively. In addition, high fat food, moldy food, and pickled vegetables consumption as well as reuse of cooking oil for frying were significantly associated with gastric cancer risk. Furthermore, intake of Ghorme (deep fried meat) was positively correlated with gastric cancer risk (OR:1.31;95%CI: 0.91-1.87). Conclusions: It can be confirmed that particular food habits which have been very common in East-Azerbaijan in the last two past decades increase risk of gastric cancer. According to our results and taking into account the long latency period of gastric cancer it can be concluded that nutrition education for a healthy diet should be performed from early childhood. However, further well designed cohort studies are needed to achieve more clear results.