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RISS 인기검색어
- 검색키워드
- 저자 : Mohsen Chiani (검색결과 2 건)
- 무료
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Elnaz Asgharkhani,Anahita Fathi Azarbayjani,Shiva Irani,Mohsen Chiani,Zahra Saffari,Dariush Norouzian,Azim Akbarzadeh,Seyed Mohammad Atyabi 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.3
Artemisinin (ART)-loaded niosome and pegylated niosomes were prepared using two different techniques. Nanosized lipid vesicles were physically characterized for entrapment efficacy and stability. Particle sizes were determined and release kinetic of the optimized formulation was carried out by dialysis method. The efficacy of the developed formulation was tested on MCF7 cells and cytotoxicity was accomplished by MTT assay. Common observation was the effect of pegylation on the reduction of vesicle size due to its hydrophilic nature. Span 60 niosomes had slightly larger vesicle size than Span 20 niosomes. Over all the good stability was observed over 60 days. In vitro drug release studies indicate gradual release of niosome over 40 h. similar trend in drug release was observed for most formulation except for the multilammellar pegylated niosomes. Pegylation of niosomes causes increased stability and efficacy of ART. Cytotoxicity ( IC50) was evaluated at different time of incubation at 48 and 72 h for selected niosomal formulations. Pegylated ART niosomes show great advantages in term of interaction with MCF-7 cell membrane. Results suggest that pegylated niosomes may be an appropriate candidate for the clinical administration of ART.
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Amiri, Boshra,Ebrahimi-Far, Meysam,Saffari, Zahra,Akbarzadeh, Azim,Soleimani, Esmaeil,Chiani, Mohsen Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Background: Breast cancer is one of the most frequent cancer types within female populations. Silibinin is a chemotherapeutic agent ative against cancer. Niosomes are biodegradable, biocompatible, safe and effective carriers for drug delivery. Objective:To prepare nanoniosomal silibinin and evaluate its cytotoxicity inthe T-47D breast cancer cell line. Materials and Methods: Niosomes were prepared by reverse phase evaporation of a mixture of span 20, silibinin, PEG-2000 and cholesterol in chloroform and methanol solvent (1:2 v/v). The solvent phase was evaporated using a rotary evaporator and the remaining gel phase was hydrated in phosphate buffer saline. Mean size, size distribution and zeta potential of niosomes were measured with a Zetasizer instrument and then nanoparticles underwent scanning electron microscopy. The drug releasing pattern was evaluated by dialysis and the cytotoxicity of nanoniosomes in T-47D cells was assessed by MTT assay. Results: Particle size, size variation and zeta potential of the niosomal nanoparticles were measured as $178.4{\pm}5.4nm$, $0.38{\pm}0.09$ and $-15.3{\pm}1.3mV$, respectively. The amount of encapsulated drug and the level of drug loading were determined $98.6{\pm}2.7%$ and $22.3{\pm}1.8%$, respectively; released drug was estimated about $18.6{\pm}2.5%$ after 37 hours. The cytotoxic effects of nanoniosome were significantly increased when compared with the free drug. Conclusions: This study finding suggests that silibinin nanoniosomes could serve as a new drug formulation for breast cancer therapy.
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