Patterns of Impaired Neurocognitive Performance on the Global Neuropsychological Assessment, and Their Brain Structural Correlates in Recent-onset and Chronic Schizophrenia

Vineeth Mohan(Vineeth Mohan ),Pravesh Parekh(Pravesh Parekh ),Ammu Lukose(Ammu Lukose ),Sydney Moirangthem(Sydney Moirangthem ),Jitender Saini(Jitender Saini ),David J. Schretlen(David J. Schretlen ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Objective: Schizophrenia is associated with impairment in multiple cognitive domains. There is a paucity of research on the effect of prolonged illness duration (≥ 15 years) on cognitive performance along multiple domains. In this pilot study, we used the Global Neuropsychological Assessment (GNA), a brief cognitive battery, to explore the patterns of cognitive impairment in recent-onset (≤ 2 years) compared to chronic schizophrenia (≥ 15 years), and correlate cognitive performance with brain morphometry in patients and healthy adults. Methods: We assessed cognitive performance in patients with recent-onset (n = 17, illness duration ≤ 2 years) and chronic schizophrenia (n = 14, duration ≥ 15 years), and healthy adults (n = 16) using the GNA and examined correlations between cognitive scores and gray matter volumes computed from T1-weighted magnetic resonance imaging images. Results: We observed cognitive deficits affecting multiple domains in the schizophrenia samples. Selectively greater impairment of perceptual comparison speed was found in adults with chronic schizophrenia (p = 0.009, η2 partial = 0.25). In the full sample (n = 47), perceptual comparison speed correlated significantly with gray matter volumes in the anterior and medial temporal lobes (TFCE, FWE p < 0.01). Conclusion: Along with generalized deficit across multiple cognitive domains, selectively greater impairment of perceptual comparison speed appears to characterize chronic schizophrenia. This pattern might indicate an accelerated or premature cognitive aging. Anterior-medial temporal gray matter volumes especially of the left hemisphere might underlie the impairment noted in this domain in schizophrenia.

Effect of inducible co-overexpression of protein disulfide isomerase and endoplasmic reticulum oxidoreductase on the specific antibody productivity of recombinant Chinese hamster ovary cells

Mohan, Chaya,Lee, Gyun Min Wiley Subscription Services, Inc., A Wiley Company 2010 Biotechnology and bioengineering Vol.107 No.2

<P>To enhance specific antibody (Ab) productivity (q<SUB>Ab</SUB>) of recombinant Chinese hamster ovary (rCHO) cells, post-translational limitations in the endoplasmic reticulum during antibody production should be relieved. Previously, we reported that overexpression of protein disulfide isomerase (PDI), which catalyzes disulfide bond exchanges and assists in protein folding of newly synthesized proteins, enhanced q<SUB>Ab</SUB> of rCHO cells by about 27% (Mohan et al., 2007, Biotechnol Bioeng 98:611–615) . Since the rate limiting step in disulfide bond formation is found to be the regeneration of oxidized PDI, the oxidation state of PDI, as well as the amount of PDI, might be important. Endoplasmic reticulum oxidoreductase (ERO1L) maintains PDI in an oxidized state so that disulfide bond formation occurs. Here, PDI and its helper protein, ERO1L were overexpressed in rCHO cells producing an Ab in an attempt to ease the bottleneck in disulfide bond formation, and hence, Ab folding and secretion. Transient expression of ERO1L alone and with PDI resulted in enhanced q<SUB>Ab</SUB> by 37% and 55%, respectively. In contrast, under stable inducible co-overexpression of PDI and ERO1L, the q<SUB>Ab</SUB> was unaffected or negatively affected by varying degrees, depending on the individual expression levels of these genes. In stable clones with altered oxidation state of PDI due to co-overexpression of PDI and ERO1L, secretion of Ab was hindered and PDI-associated retention of Ab was seen in the cells. Under transient gene expression, secretion of Ab was not compromised. The data presented here suggests a possible mechanism of PDI/ERO1L interaction with the target Ab and shows how the expression levels of these proteins could affect the q<SUB>Ab</SUB> of this Ab-producing rCHO cell line. Biotechnol. Bioeng. 2010;107: 337–346. © 2010 Wiley Periodicals, Inc.</P>

Quantum Sensing Research: A Scientometric Assessment of Global Publications during 1991-2020

Brij Mohan Gupta,Surinder Mohan Dhawan,Ghouse Modin Mamdapur 건국대학교 GLOCAL(글로컬)캠퍼스 지식콘텐츠연구소 2022 International Journal of Knowledge Content Develop Vol.12 No.3

The study presents a global research scenario in the domain of quantum sensing in quantitative and qualitative terms. The study is based on an analysis of 588 global publications in the field, sourced from the Scopus database for the period 1991-2020. The study identified key countries, organizations and authors, network collaborative linkages at national, institutional, and author level. In addition, it identified broad subject areas intersecting quantum sensing research, key journals for research communications, and broad characteristics of highly-cited papers. The study finds that the USA and Germany lead the world ranking in quantum sensing research with a combined share of 50% to the global output. The USA, Germany, and Italy are the home countries to 13 of the top 15 most productive organizations, and also the home countries to 14 of the top 15 most productive authors in the subject. The top journals publishing most research publications are Physical Review A, Physical Review Letters and New Journal of Physics. However, in the most cited journals list in the subject, Agriculture & Forest Meterology, Science and Physical Review A tops the list.

The role of rectal diclofenac and aggressive hydration with Ringer's lactate in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients

Sharma Vivek Mohan,Mathur Amit,Goyal Mohan Babu,Jat Shankar Lal 소화기인터벤션의학회 2023 International journal of gastrointestinal interven Vol.12 No.2

Background: Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is a common complication of therapeutic endoscopy. The aim of this trial was to determine whether a combination of rectal diclofenac and vigorous hydration with Ringer’s lactate is superior to the correspond-ing individual treatments for preventing PEP in high-risk patients. Methods: This randomized, open-label, controlled trial was conducted from August 2020 to January 2022. We included patients who were at high risk of developing PEP. Three intervention groups were made: group A, diclofenac sodium suppository (100 mg); group B, aggressive hydration with Ringer’s lactate; group C, a combination of diclofenac and aggressive hydration. PEP was defined as a serum amylase level > 3 times the upper limit of normal with epigastric pain within 24 hours after endoscopic retrograde cholangiopancreatography.Results: A total of 144 patients were included and 48 cases were randomized to each intervention group. The incidence of PEP was 8.3%, 10.4%, and 8.3% in groups A, B, and C, respectively. A personal history of alcohol consumption and more than one pancreatic duct guidewire cannulation were significantly associated with the development of PEP.Conclusion: No difference in the incidence of PEP was observed with or without the use of aggressive hydration. Combining aggressive hydration with a rectal nonsteroidal anti-inflammatory drug for preventing PEP cannot be recommended.

Dynamic reliability analysis framework using fault tree and dynamic Bayesian network: A case study of NPP

Mohan Rao Mamdikar,Vinay Kumar,Pooja Singh 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.4

The Emergency Diesel Generator (EDG) is a critical and essential part of the Nuclear Power Plant (NPP). Due to past catastrophic disasters, critical systems of NPP like EDG are designed to meet high dependability requirements. Therefore, we propose a framework for the dynamic reliability assessment usingthe Fault Tree and the Dynamic Bayesian Network. In this framework, the information of the component's failure probability is updated based on observed data. The framework is powerful to performqualitative as well as quantitative analysis of the system. The validity of the framework is done byapplying it on several NPP systems.

Short Term Test-Retest Reliability of Contralateral Inhibition of Distortion Product Otoacoustic Emissions

Mohan Kumar Kalaiah,Alina Lasrado,Nikita Pinto,Usha Shastri 대한청각학회 2018 Journal of Audiology & Otology Vol.22 No.4

Background and Objectives: Strength of medial olivocochlear reflex can be measured reliably using contralateral inhibition of distortion product otoacoustic emissions (DPOAEs) when its fine structure is considered. However, measurement of fine structure of DPOAE is difficult with clinical equipment. Thus, this study investigated the clinically relevant test-retest reliability of contralateral inhibition of DPOAEs. Subjects and Methods: Twenty-six young adults withnormal hearing sensitivity participated. DPOAEs were recorded at 27 discrete f2 frequenciesbetween 800 Hz and 8,000 Hz at frequency resolution of 8 points per octave with and withoutcontralateral white noise presented at 50 dB SPL. To check for short term inter-sessionreliability, contralateral inhibition of DPOAEs were recorded in three sessions, two recordingsessions on first day separated by 30 minutes and third time after one week of the first session. Within each session, DPOAEs were recorded twice in single probe-fit condition to testfor intra-session reliability. Results: Cronbach’s alpha was calculated having poor reliability (α≤0.7) of contralateral inhibition of DPOAEs in both intra-session and inter-session conditionsfor most of the tested frequencies. 95% confidence intervals of contralateral inhibition magnitudealso showed large variability. Conclusions: The current results showed that thoughDPOAE amplitudes were highly reliable across sessions, amount of inhibition of DPOAEs wasnot reliable when DPOAEs were measured at discrete frequencies. These findings are concurrentwith the literature.

Polymorphism in TiO2 under the influence of CuO and MnO2

Mohan Das, P.N,Riyas, S.,Krishnan, G. 한양대학교 세라믹연구소 2006 Journal of Ceramic Processing Research Vol.7 No.4

Titanium dioxide shows polymorphism on heating to a higher temperature. This transformation is strongly dependent on temperature and time of heating. Pure Titania pulp containing amorphous titania was heated at different temperatures and for different times. Above 650oC the anatase phase evolved and between 900-1000 oC, an anatase-rutile transformation occurred. The anatase-rutile transformation in TiO2 in the presence of CuO and MnO2 was investigated. The different phases of TiO2 were determined using powder XRD. Other methods such as chemical analysis, scanning electron microscopy, surface area measurements and crystallite size calculations were used for the characterization of the samples. The transformation temperature was found to be much lowered in the presence of the above metal oxides. Also the method of preparation of metal oxide doped TiO2 affects the polymorphism. Titanium dioxide shows polymorphism on heating to a higher temperature. This transformation is strongly dependent on temperature and time of heating. Pure Titania pulp containing amorphous titania was heated at different temperatures and for different times. Above 650oC the anatase phase evolved and between 900-1000 oC, an anatase-rutile transformation occurred. The anatase-rutile transformation in TiO2 in the presence of CuO and MnO2 was investigated. The different phases of TiO2 were determined using powder XRD. Other methods such as chemical analysis, scanning electron microscopy, surface area measurements and crystallite size calculations were used for the characterization of the samples. The transformation temperature was found to be much lowered in the presence of the above metal oxides. Also the method of preparation of metal oxide doped TiO2 affects the polymorphism.

Multilevel Inverter to Reduce Common Mode Voltage in AC Motor Drives Using SPWM Technique

Mohan M. Renge,Hiralal M. Suryawanshi 전력전자학회 2011 JOURNAL OF POWER ELECTRONICS Vol.11 No.1

In this paper, an approach to reduce common-mode voltage (CMV) at the output of multilevel inverters using a phase opposition disposed (POD) sinusoidal pulse width modulation (SPWM) technique is proposed. The SPWM technique does not require computations therefore, this technique is easy to implement on-line in digital controllers. A good tradeoff between the quality of the output voltage and the magnitude of the CMV is achieved in this paper. This paper realizes the implementation of a POD-SPWM technique to reduce CMV using a five-level diode clamped inverter for a three phase induction motor. Experimental and simulation results demonstrate the feasibility of the proposed technique.

Fabrication of polypyrrole/ZnO nanowires based organic–inorganic hybrid p-n junctions

Mohan Kumar, G.,Madhan Kumar, A.,Ilanchezhiyan, P.,Kang, T. W. Springer Science + Business Media 2015 Journal of materials science Materials in electron Vol.26 No.4

A Novel Boost PFC Converter Employing ZVS Based Compound Active Clamping Technique with EMI Filter

Mohan, P. Ram,Kumar, M. Vijaya,Reddy, O.V. Raghava The Institute of Electronics and Information Engin 2008 Journal of semiconductor technology and science Vol.8 No.1

A Boost Power Factor Correction (PFC) Converter employing Zero Voltage Switching (ZVS) based Compound Active Clamping (CAC) technique is presented in this paper. An Electro Magnetic Interference (EMI) Filer is connected at the line side of the proposed converter to suppress Electro Magnetic Interference. The proposed converter can effectively reduce the losses caused by diode reverse recovery. Both the main switch and the auxiliary switch can achieve soft switching i.e. ZVS under certain condition. The parasitic oscillation caused by the parasitic capacitance of the boost diode is eliminated. The voltage on the main switch, the auxiliary switch and the boost diode are clamped. The principle of operation, design and simulation results are presented here. A prototype of the proposed converter is built and tested for low input voltage i.e. 15V AC supply and the experimental results are obtained. The power factor at the line side of the converter and the converter efficiency are improved using the proposed technique.