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Mahshid Nikpour Nezhati,Gholam Hossein Riazi,Homayon Ahmad Panahi,Elham Moniri,Nasir Ahmad Rajabi,Mohammad Mehdi Sadughi,Natasha Rahmani Zaker,Robab Ardekani,Reihaneh Kooshkestani 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.3
The sodium salt of di ((1-hydroxy-2-benzothiazolium-1-yl) ethyliden-1,1-H-bisphosphonic acid) orthophosphate was synthesized and its toxicity and viability effects screened on two different human neuroblastoma cell lines. This novel derivative of benzothiazole provides a new compound in connection with research and therapeutic application for tumor cell growth inhibition. Benzothiazole was alkylated in reaction with bromoacetic acid and then converted to its H-bisphosphonic acid derivative in presence of H3PO3/POCl3. The procedure led to formation of two molecules of corresponding H-bisphosphonic acid which attached together via a phosphate bridge. The investigated compound exhibits activities (IC50 value) ranging from 14-23 μM (corresponding to human neuroblastoma SK-BE (2)and SK-NM-C cells).