Self-centering steel slotted friction device for seismic retrofit of beam-column joints

Mohamed Nour Eldin,Shabir Ahmed,Jinkoo Kim 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.41 No.1

A new self-centering slotted friction device (SC-SFD) is introduced for seismic retrofit and upgrading of beam-column joints. The device can be used for existing or new structures. A framework utilizing a performance-based seismic design procedure combined with a genetic algorithm (GA) optimization is used to obtain the optimum design variables of the device. A 5-story building and one-story industrial structure are used as case studies. The effectiveness of the proposed retrofit is assessed through conducting non-linear time-history response analysis (NLTHA), incremental dynamic analysis (IDA), fragility analysis, and seismic life cycle cost (LCC) evaluation. The obtained results demonstrate that the proposed retrofit is effective in reducing the maximum inter-story drift ratio (MIDR) significantly and in eliminating the residual drift. Additional engineering demand parameters, such as the floor acceleration and the base shear have been investigated to prove the superiority of the proposed retrofit technique compared to the fully rigid joint alternative. A finite element method (FEM) is used to ensure that concrete stresses after retrofit are within the acceptable limits. The retrofitted models show high energy dissipating potential compared to the bare cases. The IDA and fragility analyses show significant improvement in the retrofitted structures in terms of the median collapse capacity and seismic fragility. The probabilities of exceeding different limit states and the LCC of the retrofitted structures have been reduced significantly compared to the bare cases. Based on these findings, the proposed retrofit is recommended for similar structures to improve their resilience against earthquakes and to reduce the total seismic LCC.

Optimum distribution of steel slit-friction hybrid dampers based on life cycle cost

Mohamed Nour Eldin,Jaegoo Kim,김진구 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.27 No.5

This study investigated the seismic performance of a hybrid damper composed of a steel slit plate and friction pads, and an optimum retrofit scheme was developed based on life cycle cost. A sample hybrid damper was tested under cyclic loading to confirm its validity as a damping device and to construct its nonlinear analysis model. The effectiveness of the optimum damper distribution schemes was investigated by comparing the seismic fragility and the life cycle costs of the model structure before and after the retrofit. The test results showed that the damper behaved stably throughout the loading history. Numerical analysis results showed that the slit-friction hybrid dampers optimally distributed based on life cycle cost proved to be effective in minimizing the failure probability and the repair cost after earthquakes.

Seismic retrofit of steel structures with re-centering friction devices using genetic algorithm and artificial neural network

Mohamed Nour Eldin,Masoum M,Jinkoo Kim 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.47 No.2

In this study, a new recentering friction device (RFD) to retrofit steel moment frame structures is introduced. The device provides both self-centering and energy dissipation capabilities for the retrofitted structure. A hybrid performance-based seismic design procedure considering multiple limit states is proposed for designing the device and the retrofitted structure. The design of the RFD is achieved by modifying the conventional performance-based seismic design (PBSD) procedure using computational intelligence techniques, namely, genetic algorithm (GA) and artificial neural network (ANN). Numerous nonlinear time-history response analyses (NLTHAs) are conducted on multi-degree of freedom (MDOF) and single-degree of freedom (SDOF) systems to train and validate the ANN to achieve high prediction accuracy. The proposed procedure and the new RFD are assessed using 2D and 3D models globally and locally. Globally, the effectiveness of the proposed device is assessed by conducting NLTHAs to check the maximum inter-story drift ratio (MIDR). Seismic fragilities of the retrofitted models are investigated by constructing fragility curves of the models for different limit states. After that, seismic life cycle cost (LCC) is estimated for the models with and without the retrofit. Locally, the stress concentration at the contact point of the RFD and the existing steel frame is checked being within acceptable limits using finite element modeling (FEM). The RFD showed its effectiveness in minimizing MIDR and eliminating residual drift for low to mid-rise steel frames models tested. GA and ANN proved to be crucial integrated parts in the modified PBSD to achieve the required seismic performance at different limit states with reasonable computational cost. ANN showed a very high prediction accuracy for transformation between MDOF and SDOF systems. Also, the proposed retrofit showed its efficiency in enhancing the seismic fragility and reducing the LCC significantly compared to the un-retrofitted models.

Anti-proliferative Activities of Metallic Nanoparticles in an in Vitro Breast Cancer Model

Loutfy, Samah A,Al-Ansary, Nadia A,Abdel-Ghani, Nour T,Hamed, Ahmed R,Mohamed, Mona B,Craik, James D,Eldin, Taher A. Salah,Abdellah, Ahmed M,Hussein, Yassmein,Hasanin, MTM,Elbehairi, Serag Eldin I Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Aims: To investigate effect of metallic nanoparticles, silver (AgNPs) and gold nanoparticles (AuNPs) as antitumor treatment in vitro against human breast cancer cells (MCF-7) and their associated mechanisms. This could provide new class of engineered nanoparticles with desired physicochemical properties and may present newer approaches for therapeutic modalities to breast cancer in women. Materials and Methods: A human breast cancer cell line (MCF-7) was used as a model of cells. Metallic nanoparticles were characterized using UV-visible spectra and transmission electron microscopy (TEM). Cytotoxic effects of metallic nanoparticles on MCF-7 cells were followed by colorimetric SRB cell viability assays, microscopy, and cellular uptake. Nature of cell death was further investigated by DNA analysis and flow cytometry. Results: Treatment of MCF-7 with different concentrations of 5-10nm diameter of AgNPs inhibited cell viability in a dose-dependent manner, with IC50 value of $6.28{\mu}M$, whereas treatment of MCF-7 with different concentrations of 13-15nm diameter of AuNPs inhibited cell viability in a dose-dependent manner, with IC50 value of $14.48{\mu}M$. Treatment of cells with a IC50 concentration of AgNPs generated progressive accumulation of cells in the S phase of the cell cycle and prevented entry into the M phase. The treatment of cells with IC50 concentrations of AuNPs similarly generated progressive accumulation of cells in sub-G1 and S phase, and inhibited the entrance of cells into the M phase of the cell cycle. DNA fragmentation, as demonstrated by electrophoresis, indicated induction of apoptosis. Conclusions: Our engineered silver nanoparticles effectively inhibit the proliferation of human breast carcinoma cell line MCF-7 in vitro at high concentration ($1000{\mu}M$) through apoptotic mechanisms, and may be a beneficial agent against human carcinoma but further detailed study is still needed.

Gene Expression Profiling of Non-Hodgkin Lymphomas

Zekri, Abdel-Rahman Nabawy,Hassan, Zeinab Korany,Bahnassy, Abeer Ahmed,Eldahshan, Dina Hassan,El-Rouby, Mahmoud Nour Eldin,Kamel, Mahmoud Mohamed,Hafez, Mohamed Mahmoud Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Background: Chromosomal translocations are genetic aberrations associated with specific non-Hodgkin lymphoma (NHL) subtypes. This study investigated the differential gene expression profile of Egyptian NHL cases based on a microarray approach. Materials and Methods: The study included tissue samples from 40 NHL patients and 20 normal lymph nodes used as controls. Total RNA was extracted and used for cDNA microarray assays. The quantitative real time polymerase chain reaction was used to identify the aberrantly expressed genes in cancer. Results: Significant associations of 8 up-regulated and 4 down-regulated genes with NHL were observed. Aberrant expression of a new group of genes not reported previously was apparent, including down-regulated NAG14 protein, 3 beta hydroxy-delta 5-c27 steroid oxi-reductase, oxi-glutarate dehydrogenase (lipo-amide), immunoglobulin lambda like polypeptide 3, protein kinase x linked, Hmt1, and caveolin 2 Tetra protein. The up-regulated genes were Rb binding protein 5, DKFZP586J1624 protein, protein kinase inhibitor gamma, zinc finger protein 3, choline ethanolamine phospho-transferase CEPT1, protein phosphatase, and histone deacetylase-3. Conclusions: This study revealed that new differentially expressed genes that may be markers for NHL patients and individuals who are at high risk for cancer development.