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RISS 인기검색어
- 검색키워드
- 저자 : Mohamed Eltohamy (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Biomimetic Designing of Functional Silk Nanotopography Using Self-assembly
Kundu, Banani,Eltohamy, Mohamed,Yadavalli, Vamsi K.,Kundu, Subhas C.,Kim, Hae-Won American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.42
<P>In nature inorganic organic building units create multifunctional hierarchical architectures. Organic silk protein is particularly attractive in this respect because of its micro-nanoscale structural blocks that are attributed to sophisticated hierarchical assembly imparting flexibility and compressibility to designed biohybrid materials. In the present study, aqueous silk fibroin is assembled to form nano/microtopography on inorganic silica surface via a facile diffusion-limited aggregation process. This process is driven by electrostatic interaction and only possible at a specified aminated surface chemistry. The self-assembled topography depends on the age and concentration of protein solution as well as on the surface charge distribution of the template. The self-assembled silk trails closely resemble natural cypress leaf architecture, which is considered a structural analogue of neuronal cortex. This assembled surface significantly enhances anchorage of neuronal cell and cytoskeletal extensions, providing an effective nano/microtopographical cue for cellular recognition and guidance.</P>
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Kim, Tae‐,Hyun,Kim, Meeju,Eltohamy, Mohamed,Yun, Ye‐,Rang,Jang, Jun‐,Hyeog,Kim, Hae‐,Won Wiley Subscription Services, Inc., A Wiley Company 2013 Journal of biomedical materials research. Part A Vol.101 No.6
<P><B>Abstract</B></P><P>We report the ability of aminated mesoporous silica nanoparticles (MSN–NH<SUB>2</SUB>) with large mesopore space and positive‐charged surface to deliver genes within rat mesenchymal stem cells (MSCs). The amine functionalized inorganic nanoparticles were complexed with bone morphogenetic protein‐2 (BMP2) plasmid DNA (pDNA) to study their transfection efficiency in MSCs. Intracellular uptake of the complex BMP2 pDNA/MSN–NH<SUB>2</SUB> occurred significantly, with a transfection efficiency of approximately 68%. Furthermore, over 66% of the transfected cells produced BMP2 protein. The osteogenic differentiation of the transfected MSCs was demonstrated by the expression of bone‐related genes and proteins including bone sialoprotein, osteopontin, and osteocalcin. The MSN–NH<SUB>2</SUB> delivery vehicle for BMP2 pDNA developed in this study may be a potential gene delivery system for bone tissue regeneration. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.</P>
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Sang Shin, Ueon,Seo, Jae-Won,Kundu, Banani,Kim, Hae-Won,Eltohamy, Mohamed Elsevier 2017 Microporous and mesoporous materials Vol.243 No.-
<P><B>Abstract</B></P> <P>A facile straightforward eco-friendly approach for the preparation of super-paramagnetic, thermo-responsive inorganic/organic hybrid nanoparticle system is described: several super-paramagnetic Fe<SUB>3</SUB>O<SUB>4</SUB> nanoparticle clusters into silica shell using sol-gel process tailoring the silica shell thickness ∼40 nm. Use of poly (N-isopropylacrylamide-co-N-vinylimidazole-co-Acrylic acid) (PNIBIM-AA) polymer acts as specific structure directing agent, which covalently linked with silica-magnetic core via free-radical polymerization; leads directly to core-shell-corona hybrid nano-carrier system. Functional properties such as uniformity in size, pH and magnetic momentum are achieved. Effect of temperature/pH dependent bi-phasic (burst initial followed by sustain) release of model chemotherapeutic molecule Doxorubicin on MCF7 (breast adenocarcinoma cells from human) is investigated comprehensively including MTS assay, calcein AM/ethidium bromide assay and actin filament arrangements. DOX-loaded MNP/MSN/p-NBIM-AA (concentration range 50–1000 μg/ml) induces dose-dependent cytotoxicity in response to released DOX. Untreated viable cells become green upon hydrolysis of intra cellular esterases activity with well stretched actin filament compared to treated dead red colored round cells. Taken together, the designed nano-carrier is a potential multifunctional delivery platform for therapeutic applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> One-step facile method of preparation of magnetic particles, embedded within the Mesoporous Silica loaded doxorubicin. </LI> <LI> Magnetic particles-silica core is shelled with pH and thermo-sensitive PNIPAM-co-VIAA corona providing stimuli-responsiveness. </LI> <LI> Fabrication method is simple, cheap and designed nano-carrier effectively deliver model chemotherapeutic agent to cancer cell. </LI> <LI> Opens up new direction in development of cost-effective nano-hybrid delivery vehicles in cancer treatment. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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