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Min, Hae-Ki,Mirshahi, Faridoddin,Verdianelli, Aurora,Pacana, Tommy,Patel, Vaishali,Park, Chun-Geon,Choi, Aejin,Lee, Jeong-Hoon,Park, Chung-Berm,Ren, Shunlin,Sanyal, Arun J. American Physiological Society 2015 American journal of physiology, Gastrointestinal a Vol.308 No.9
<P>The status of the GP130-STAT3 signaling pathway in humans with nonalcoholic fatty liver disease (NAFLD) and its relevance to disease pathogenesis are unknown. The expression of the gp130-STAT3 axis and gp130 cytokine receptors were studied in subjects with varying phenotypes of NAFLD including nonalcoholic steatohepatitis (NASH) and compared with lean and weight-matched controls without NAFLD. Gp130 and its downstream signaling element (Tyk2 and STAT3) expression were inhibited in obese controls whereas they were increased in NAFLD. IL-6 levels were increased in NASH and correlated with gp130 expression (<I>P</I> < 0.01). Palmitate inhibited gp130-STAT3 expression and signaling. IL-6 and palmitate inhibited hepatic insulin signaling via STAT3-dependent and independent mechanisms, respectively. STAT3 overexpression reversed palmitate-induced lipotoxicity by increasing autophagy (ATG7) and decreasing endoplasmic reticulum stress. These data demonstrate that the STAT3 pathway is activated in NAFLD and can worsen insulin resistance while protecting against other lipotoxic mechanisms of disease pathogenesis.</P>
Effect of Processing Parameters and Glycerin Addition on the Properties of Al Foams
Hossein Gilani,Sajjad Jafari,Roozbeh Gholami,Ali Habibolahzadeh,Mohammad Mirshahi 대한금속·재료학회 2012 METALS AND MATERIALS International Vol.18 No.2
Aluminum foam has been produced by sintering and dissolution processes using NaCl powders as a space holder. In this research, glycerin is used as a novel lubricant along with acetone. The effects of the processing parameters including compacting pressure, sintering temperatures (620, 640 and 650 °C), size, and volume fraction of the space holder, on the physical and mechanical properties of the produced foams have been investigated. Due to segregation of the Al and NaCl powders at high compaction pressures, spalling of Al foams was observed. Meanwhile, adding small amounts of acetone and glycerin to the mixture ensures homo-geneity and prevents segregation of dissimilar powders at varying pressure. Moreover, the addition of glycerin provides an improved homogenous stress distribution within the produced foams during mechanical testing,which in turn halts crack propagation. Meanwhile, an alternative technique to remove NaCl particles during the dissolution stage has been proposed. The results showed that high quality foams were successfully produced under a compaction pressure range of 250-265 MPa and sintering temperature of 650 °C.