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Suzuki, Minoru,Amano, Morikazu,Choi, Jihyung,Park, Heon Joo,Williams, Brent W.,Ono, Koji,Song, Chang W. BioOne (Radiation Research Society) 2006 Radiation research Vol.165 No.5
<P>It has been reported that beta-lapachone (beta-lap), a bioreductive anti-cancer drug, synergistically interacts with ionizing radiation and that the sensitivity of cells to beta-lap is closely related to the activity of NAD(P)H:quinone oxidoreductase 1 (NQO1). Here we report the results of our studies of mechanisms underlying the synergistic interaction of beta-lap and radiation in killing cancer cells using the DU-145 human prostate cancer cell line. The clonogenic cell death caused by the combination of radiation and beta-lap was synergistic when beta-lap was administered 0-10 h after irradiation but not when it was given before irradiation. The expression and activity of NQO1 increased significantly and remained elevated for longer than 12 h after 4 Gy irradiation, suggesting that the long-lasting elevation of NQO1 sensitized the cells to beta-lap. Studies with split-dose irradiation demonstrated that beta-lap given immediately after irradiation effectively inhibited sublethal radiation damage (SLD) repair. Taken together, these results lead us to conclude that the synergistic interaction between beta-lap and radiation in killing cells is the result of two distinct mechanisms: First, radiation sensitizes cells to beta-lap by up-regulating NQO1, and second, beta-lap sensitizes cells to radiation by inhibiting SLD repair. The combination of beta-lap and radiotherapy is potentially promising modality for the treatment of cancer in humans.</P>
Two-Degree-of-Freedom Control of a Stacker Crane
Minoru Sasaki,Toshimi Shimizu,Kengo Suzuki,Shingo Naito,Satoshi Ito 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper presents a motion control of a stacker crane applying a two-degree-of-freedom control. The two-degree-of-freedom control system consists of a feed forward controller based on an inverse system and a feed backcontroller with suppressing the vibration effectively and stabilizing. Feedback control of the motion of the stacker crane is derived by considering the time rate of change of the total energy of the system. This approach has the advantage overthe conventional methods in the respect that it allows one to deal directly with the system’s partial differential equations without resorting to approximations. The paper concludes by presenting some numerical results and experimental results for a special case using a proposed control system. These results show that the two-degree-of-freedom control system can realize faster and precise tracking control of the flexible stacker crane system.
( Yutaka Suzuki ),( Katshujiko Ogawa ),( Minoru Oishi ),( Hiroshi Shiota ),( Satoshi Kamei ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Reports that smoking infl uences the regional cerebral fl ood fl ow (CBF), brain atrophy, and cognition in Parkinson disease (PD) are few. Methods: Regional CBF and brain atrophy, and cognition were studied in PD with (PDS) or without (PDNS) a smoking habit, and normal non-smoking controls. Results: PD groups (PDS and PDNS) had a decreased CBF. BDI and FAB scores in PD groups were lower compared with those in controls. Also FAB scores in PDS were lower compared with those in PDNS. Conclusions: Results of the decreased CBF could be associated with the results of BDI, FAB and WMS-R in PD.
Mizuo, Keisuke,Narita, Minoru,Miyagawa, Kazuya,Suzuki, Tsutomu The Korean Society of Applied Pharmacology 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.4
Bisphenol A (BPA) is one of the most common endocrine disrupters. In the last decade, the number of studies concerning the effects of chronic treatment with BPA on the development of the central nervous system (CNS) has increased. However, little is known about the effects of chronic exposure to BPA on higher brain functions such as memory or psychomotor functions. Here, we report our following findings: (1) Prenatal and neonatal exposure to BPA enhances psychostimulant-induced rewarding effects, results in the up- or downregulation of dopamine receptors, causes memory impairment, and decreases choline acetyltransferase (ChAT) activity. (2) BPA activates astrocytes in vivo and in vitro. These findings suggest that prenatal and neonatal exposure to BPA affects the development of the CNS.