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RISS 인기검색어
- 검색키워드
- 저자 : Minna Shin (검색결과 3 건)
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Shin, Minna,Lee, Bo-Mi,Kim, Okwha,Tran, Huynh Nguyen Khanh,Lee, Suhyun,Hwangbo, Cheol,Min, Byung-Sun,Lee, Jeong-Hyung The Royal Society of Chemistry 2018 Food & function Vol.9 No.7
<P><I>Ziziphus jujuba</I> var. <I>inermis</I> Rehder is an edible fruit-producing species of the Rhamnaceae family. In the present study, we isolated eight triterpenoids (1-8) from the fruits of <I>Z. jujuba</I> var. <I>inermis</I> and evaluated their apoptotic cell-death-inducing activities in human cancer cell lines (A549, PC-3, and MDA-MB-231). The structures of compounds 1-8 were determined by spectroscopic methods. Among these, four isomers of coumaroyl alphitolic acid showed potent cytotoxic activities on these cancer cells: 3-<I>O-cis-p</I>-coumaroyl alphitolic acid (3), 3-<I>O-trans-p</I>-coumaroyl alphitolic acid (4), 2-<I>O-trans-p</I>-coumaroyl alphitolic acid (5), and 2-<I>O-cis-p</I>-coumaroyl alphitolic acid (6). Moreover, compounds 3-6 induced apoptotic cell death in a concentration-dependent manner. We further investigated the apoptosis-inducing effects of compound 4 in PC-3 cells which triggered the cleavage of procaspase-3, procaspase-7, procaspase-8, bid, and PARP. Compound 4 increased both the mitochondrial reactive oxygen species (ROS) production and the phosphorylation of p38 MAPK (mitogen-activated protein kinase), but decreased the mitochondrial membrane potential. Pretreatment with Mito-TEMPO (a specific mitochondrial-targeted antioxidant) or a specific p38 inhibitor (SB203580) attenuated apoptotic cell death triggered by compound 4 which suggests that compound 4 may induce apoptotic cell death in these cancer cells by increasing the mitochondrial ROS production as well as the subsequent p38 MAPK activation. The study findings provide a rational base to use <I>Ziziphus</I> extracts for cancer treatments in traditional oriental medicine.</P>
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Clinical profile of Asian and African strains of Zika virus in immunocompetent mice
Shin, Minna,Kim, Jini,Park, Jeongho,Hahn, Tae-Wook The Korean Society of Veterinary Science 2021 大韓獸醫學會誌 Vol.61 No.2
The mosquito-borne pathogen Zika virus may result in neurological disorders such as Guillain-Barré syndrome and microcephaly. The virus is classified as a member of the Flaviviridae family and its wide spread in multiple continents is a significant threat to public health. So, there is a need to develop animal models to examine the pathogenesis of the disease and to develop vaccines. To examine the clinical profile during Zika virus infection, we infected neonatal and adult wild-type mice (C57BL/6 and Balb/c) and compared the clinical signs of African-lineage strain (MR766) and Asian-lineage strain (PRVABC59, MEX2-81) of Zika virus. Consistent with previous reports, eight-week-old female Balb/c mice infected with these viral strains showed no changes in body weight, survival rate, and neurologic signs, but demonstrated increases in the weights of spleens and hearts. However, one-day-old neonates showed significantly lower survival rate and body weight with the African-lineage strain than the Asian-lineage strain. These results confirmed the pathogenic differences between Zika virus strains. We also evaluated the clinical responses in neonatal and adult mice of different strains. Our findings suggest that these are useful mouse models for characterization of Zika virus for vaccine development.
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Van Tan Do,Quang Lam Truong,Hoai Thu Dao,Thi Lan Nguyen,Minna Shin,Kyeong Ryeol Shin,Tae-Wook Hahn 대한수의학회 2023 大韓獸醫學會誌 Vol.63 No.2
Porcine epidemic diarrhea (PED) is characterized by acute enteritis, watery diarrhea, weight loss, dehydration, and death, with high mortality in neonatal piglets. In this study, 3 virus isolates collected in Vietnam between 2016 and 2017 were propagated successfully in Vero cells at high virus titers. Sequence analysis of the fulllength spike (S) gene showed that all 3 isolates belong to genogroup 2b, which is closely related to other prevalent Asian strains. A comparison of the amino acid sequence revealed a 98.19% to 99.13% homology with the Vietnam isolates circulating during 2013–2015, suggesting that field PED viruses (PEDVs) are evolving continuously. Experiments in animals showed that the antisera from guinea pigs immunized with the vaccine strain resulted in higher levels (5 log2) of neutralizing antibodies against the homologous strain and a relatively moderate level of neutralizing antibodies against the field isolates. This finding would be helpful in selecting a PEDV strain for vaccine development.
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