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Kim, Hye-Jin,Kwon, Sojung,Nam, Seo Hee,Jung, Jae Woo,Kang, Minkyung,Ryu, Jihye,Kim, Ji Eon,Cheong, Jin-Gyu,Cho, Chang Yun,Kim, Somi,Song, Dae-Geun,Kim, Yong-Nyun,Kim, Tai Young,Jung, Min-Kyo,Lee, Kyun The Federation of American Societies for Experimen 2017 The FASEB Journal Vol.31 No.4
<P>Membrane proteins sense extracellular cues and transduce intracellular signaling to coordinate directionality and speed during cellular migration. They are often localized to specific regions, as with lipid rafts or tetraspanin-enriched microdomains; however, the dynamic interactions of tetraspanins with diverse receptors within tetraspanin-enriched microdomains on cellular surfaces remain largely unexplored. Here, we investigated effects of tetraspan(in) TM4SF5 (transmembrane 4 L6 family member 5)-enriched microdomains (T5ERMs) on the directionality of cell migration. Physical association of TM4SF5 with epidermal growth factor receptor (EGFR) and integrin alpha 5 was visualized by live fluorescence cross-correlation spectroscopy and higher-resolution microscopy at the leading edge of migratory cells, presumably forming TM4SF5-enriched microdomains. Whereas TM4SF5 and EGFR colocalized at themigrating leading region more than at the rear, TM4SF5 and integrin a5 colocalized evenly throughout cells. Cholesterol depletion and disruption in TM4SF5 post-translational modifications, including N-glycosylation and palmitoylation, altered TM4SF5 interactions and cellular localization, which led to less cellular migration speed and directionality in 2-or 3-dimensional conditions. TM4SF5 controlled directional cell migration and invasion, and importantly, these TM4SF5 functions were dependent on cholesterol, TM4SF5 post-translational modifications, and EGFR and integrin alpha 5 activity. Altogether, we showed that TM4SF5 dynamically interacted with EGFR and integrin a5 in migratory cells to control directionality and invasion.-Kim, H.-J., Kwon, S., Nam, S. H., Jung, J. W., Kang, M., Ryu, J., Kim, J. E., Cheong, J.-G., Cho, C. Y., Kim, S., Song, D.-G., Kim, Y.-N., Kim, T. Y., Jung, M.-K., Lee, K.-M., Pack, C.-G., Lee, J. W. Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2-and 3-dimensional environments. FASEB J. 31, 1461-1481 (2017). www.fasebj.org</P>
Yongsik Kim,Minkyung Bae,Woojoon Kim,Dongsik Kong,Hyun Kwang Jung,Hyungtak Kim,Sunwoong Kim,Dong Myong Kim,Dae Hwan Kim IEEE 2012 IEEE transactions on electron devices Vol.59 No.10
<P>A combination of the multifrequency <I>C</I>- <I>V</I> and the generation-recombination current spectroscopy is proposed for a complete extraction of density of states (DOS) in amorphous InGaZnO thin-film transistors (a-IGZO TFTs) over the full subband-gap energy range (<I>EV</I> ≤ <I>E</I> ≤ <I>EC</I>) including the interface trap density between the gate oxide and the a-IGZO active layer. In particular, our result on the separate extraction of acceptor- and donor-like DOS is noticeable for a systematic design of amorphous oxide semiconductor TFTs because the former determines their dc characteristics and the latter does their threshold voltage (<I>VT</I>) instability under practical operation conditions. The proposed approach can be used to optimize the fabrication process of thin-film materials with high mobility and stability for mass-production-level amorphous oxide semiconductor TFTs.</P>
Extraction of Subgap Donor States in a-IGZO TFTs by Generation–Recombination Current Spectroscopy
Minkyung Bae,Yongsik Kim,Sungchul Kim,Dong Myong Kim,Dae Hwan Kim IEEE 2011 IEEE electron device letters Vol.32 No.9
<P>A physics-based generation-recombination current (JG r) spectroscopy is proposed for the extraction of the sub gap donorlike density of states (DOS) of amorphous InGaZnO thin-film transistors. Physics-based Shockley-Read-Hall recombination through the subgap DOS over the bandgap is fully considered, and the potential for the carrier concentration is calculated through the DeAOTS model. The extracted parameters for the exponential deep donorlike states are N<SUB>DD</SUB> = 5.5 × 10<SUP>21</SUP> [cm<SUP>-3</SUP> · eV<SUP>-1</SUP>] and kT<SUB>DD</SUB> = 0.115 [eV].</P>
Minkyung Bae,Yongsik Kim,Dongsik Kong,Hyun Kwang Jeong,Woojoon Kim,Jaehyeong Kim,Inseok Hur,Dong Myong Kim,Dae Hwan Kim IEEE 2011 IEEE electron device letters Vol.32 No.11
<P>Analytical drain current and gate capacitance models for amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) over sub- and above-threshold regions are proposed by adopting an effective carrier density for the dominant carrier density. The effective carrier density fully considers the free carriers in the conduction band, the localized subgap deep states, and tail states over the bandgap for analytical <I>I</I>-<I>V</I> and <I>C</I>-<I>V</I> characteristics. The proposed analytical models are verified by comparing the measured <I>I</I>-<I>V</I> and <I>C</I>-<I>V</I> characteristics. The proposed models make a time-efficient simulation of a-IGZO TFT-based circuits possible due to their analytical form.</P>
Kim, Minkyung,Kim, Minjoo,Kang, Miso,Yoo, Hye Jin,Kim, Min Sun,Ahn, Young-Tae,Sim, Jae-Hun,Jee, Sun Ha,Lee, Jong Ho The Royal Society of Chemistry 2017 Food & Function Vol.8 No.1
<P>Our previous study showed that supplementation with a combination of<I>Lactobacillus curvatus</I>(<I>L. curvatus</I>) HY7601 and<I>Lactobacillus plantarum</I>(<I>L. plantarum</I>) KY1032 reduced the body weight, body fat percentage, body fat mass and L1 subcutaneous fat area in overweight subjects. We aimed to evaluate whether the changes in adiposity after supplementation with<I>Lactobacillus</I>strains were associated with metabolic intermediates. A randomized, double-blind, placebo-controlled study was conducted on 66 non-diabetic and overweight individuals. Over a 12-week period, the probiotic group consumed 2 g of probiotic powder, whereas the placebo group consumed the same product without the probiotics. To investigate metabolic alterations, we performed plasma metabolomics using ultra-performance liquid chromatography and mass spectrometry (UPLC-LTQ/Orbitrap MS). Probiotic supplementation significantly increased the levels of octenoylcarnitine (C8:1), tetradecenoylcarnitine (C14:1), decanoylcarnitine (C10) and dodecenoylcarnitine (C12:1) compared with the levels from placebo supplementation. In the probiotic group, the changes in the body weight, body fat percentage, body fat mass and L1 subcutaneous fat area were negatively associated with changes in the levels of C8:1, C14:1, C10 and C12:1 acylcarnitines. In overweight individuals, probiotic-induced weight loss and adiposity reduction from the probiotic supplementation were associated with an increase in medium-chain acylcarnitines.</P>
Kim, Jaehyeong,Jang, Jaeman,Bae, Minkyung,Lee, Jaewook,Kim, Woojoon,Hur, Inseok,Jeong, Hyun Kwang,Kim, Dong Myong,Kim, Dae Hwan The Institute of Electronics and Information Engin 2013 Journal of semiconductor technology and science Vol.13 No.1
In this work, we report extraction of the density-of-states (DOS) in polymer-based organic thin film transistors through the multi-frequency C-V spectroscopy. Extracted DOS is implemented into a TCAD simulator and obtained a consistent output curves with non-linear characteristics considering the contact resistance effect. We employed a Schottky contact model for the source and drain to fully reproduce a strong nonlinearity with proper physical mechanisms in the output characteristics even under a very small drain biases. For experimental verification of the model and extracted DOS, 2 different OTFTs (P3HT and PQT-12) are employed. By controlling the Schottky contact model parameters in the TCAD simulator, we accurately reproduced the nonlinearity in the output characteristics of OTFT.
Minkyung Kim,Sun-Won Park,Jun-Young Lee,Hongrae Kim,Jung Hyo Rhim,Soowon Park,Jee-Young Lee,Hwancheol Son,Yu Kyeong Kim,Sang Hyung Lee 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.7
Objective The distinction between idiopathic normal pressure hydrocephalus (iNPH) and hydrocephalus ex vacuo caused by encephalic volume loss remains to be established. This study aims to investigate radiological parameters as clinically useful tools to discriminate iNPH from hydrocephalus ex vacuo caused by Alzheimer’s disease (AD). Methods A total of 54 patients with ventriculomegaly (iNPH, 25; hydrocephalus ex vacuo, 29) were recruited in this study. Consequently, nine radiological parameters were compared between iNPH and hydrocephalus ex vacuo using magnetic resonance imaging (MRI). Results A small callosal angle (CA), the Sylvian fissure dilatation, and absence of narrowing of superior parietal sulci discriminated the iNPH group from the hydrocephalus ex vacuo group (p<0.05). The final binary logistic regression model included narrowing of superior parietal sulci, degrees of the CA, and height of the Sylvian fissure after controlling for age and global Clinical Dementia Rating (CDR). The composite score made from these three indicators (narrowing of superior parietal sulci, degrees of the CA, and height of the Sylvian fissure) was statistically different between iNPH and hydrocephalus ex vacuo. Conclusion The narrowing of the CA, dilatation of the Sylvain fissure, and narrowing of superior parietal sulci may be used as radiological key indices and noninvasive tools for the differential diagnosis of iNPH from hydrocephalus ex vacuo.
Haptic Speedometer Using Linear Characteristics
Minkyung Kim,Taehoon Song,Soonmook Jung,Hyunwook Jung,Myungjin Kim,Gihoon Go,Hyungmin Kim,Miyung Kang,Key Ho Kwon,Jae Wook Jeon 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
Drivers have to change their sightline to focus on the vehicle’s visual speedometer to check the speed at which they are travelling. This may be a dangerous loss of concentration. A head-up display was developed to solve this issue. HUD has several issues. Large amounts of visual information can create visual clutter and degrade the driver’s information processing due to cognitive overload. The HUD rivets their attention, diverting it from other sources. Driving safely and comfortably, we propose a new type of speedometer that lets drivers know their speed using vibro-tactile sense. The speedometer gives vibration feedback to drivers by its intensity, duration and position switching speed. Those three factors are modified linearly depending on the driving speed. Analysis demonstrates the proposed haptic speedometer helps drivers know the speed information precisely and intuitively.