http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Enhanced Rg3 negatively regulates Th1 cell responses
Minkyoung Cho,최가람,심인보,Yeonseok Chung 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.1
Background: Korean Red Ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities. How they impact helper T cell-mediated responses is not fully explored. In this study, we attempted to evaluate the effect of KRG extract (KRGE) and ginsenoside Rg3 on Th1 cell responses. Methods: Using well-characterized T cell in vitro differentiation systems, we examined the effects of KRGE or enhanced Rg3 on the Th1-inducing cytokine production from dendritic cells (DC) and the naïve CD4þ T cells differentiation to Th1 cells. Furthermore, we examined the change of Th1 cell population in the intestine after treatment of enhanced Rg3. The influence of KRGE or enhanced Rg3 on Th1 cell differentiation was evaluated by fluorescence-activated cell sorting, enzyme-linked immunosorbent assay, and quantitative real-time polymerase chain reaction. Results: KRGE significantly inhibited the production level of IL-12 from DCs and subsequent Th1 cell differentiation. Similarly, enhanced Rg3 significantly suppressed the expression of interferon gamma (IFNg) and T-bet in T cells under Th1-skewing condition. Consistent with these effects in vitro, oral administration of enhanced Rg3 suppressed the frequency of Th1 cells in the Peyer’s patch and lamina propria cells in vivo. Conclusion: Enhanced Rg3 negatively regulates the differentiation of Th1 cell in vitro and Th1 cell responses in the gut in vivo, providing fundamental basis for the use of this agent to treat Th1-related diseases.
Enhanced Rg3 negatively regulates Th1 cell responses
Cho, Minkyoung,Choi, Garam,Shim, Inbo,Chung, Yeonseok The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.1
Background: Korean Red Ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities. How they impact helper T cell-mediated responses is not fully explored. In this study, we attempted to evaluate the effect of KRG extract (KRGE) and ginsenoside Rg3 on Th1 cell responses. Methods: Using well-characterized T cell in vitro differentiation systems, we examined the effects of KRGE or enhanced Rg3 on the Th1-inducing cytokine production from dendritic cells (DC) and the naïve $CD4^+$ T cells differentiation to Th1 cells. Furthermore, we examined the change of Th1 cell population in the intestine after treatment of enhanced Rg3. The influence of KRGE or enhanced Rg3 on Th1 cell differentiation was evaluated by fluorescence-activated cell sorting, enzyme-linked immunosorbent assay, and quantitative real-time polymerase chain reaction. Results: KRGE significantly inhibited the production level of IL-12 from DCs and subsequent Th1 cell differentiation. Similarly, enhanced Rg3 significantly suppressed the expression of interferon gamma ($IFN{\gamma}$) and T-bet in T cells under Th1-skewing condition. Consistent with these effects in vitro, oral administration of enhanced Rg3 suppressed the frequency of Th1 cells in the Peyer's patch and lamina propria cells in vivo. Conclusion: Enhanced Rg3 negatively regulates the differentiation of Th1 cell in vitro and Th1 cell responses in the gut in vivo, providing fundamental basis for the use of this agent to treat Th1-related diseases.
사회복지시설의 직장 내 괴롭힘에 관한 사회복지종사자들의 경험 : 개념도 연구법 중심으로
조민경(Cho MinKyoung),이지연(Lee JeeYon) 학습자중심교과교육학회 2021 학습자중심교과교육연구 Vol.21 No.18
목적 사회복지시설의 사회복지종사자들이 인식하는 직장 내 괴롭힘에 따른 어려움과 직장 내 괴롭힘 극복요인을 “개념도 연구법”을 중심으로 하여 연구하였으며 사회복지종사자들이 직장 내 괴롭힘을 경험했을 때 겪는 어려움과 직장 내 괴롭힘의 어려움을 극복하는 요인이 무엇인지 알아보았다. 방법 최근 5년 이내에 직장 내 괴롭힘의 경험이 있었던 사회복지종사자들 10명을 대상으로 개별 면접을 실시하였고, 어려움 관련 핵심 문장 79개, 극복요인 관련 핵심문장 62개를 도출하였다. 이어서 사회복지시설 직장 내 괴롭힘에 따른 어려움에 대한 공감 수준, 사회복지시설 직장 내 괴롭힘에 대한 극복요인 중요도 수준의 분석을 진행하였고, 이러한 자료를 바탕으로 ‘다차원 척도법’과 ‘위계적 군집분석’을 실시하였다. 결과 어려움은 2차원의 범주 8개로 분류되었으며, 극복요인은 2차원의 범주 6개로 분류되었다. 분석 결과 사회복지시설의 직장 내 괴롭힘에 따른 어려움에 대한 범주는 ‘사회복지시설 및 공공기관에 대한 신뢰도 하락’, ‘세상과 사회복지시설에 대한 냉소적 시각변화’, ‘심리적인 고통과 부정적인 정서’, ‘고립 및 배척’, ‘관리자⋅동료들의 관계적 괴롭힘’, ‘정신⋅신체상 문제 증상과 일상생활의 어려움’, ‘고의적, 교묘한 괴롭힘’, ‘업무상 불이익처분’의 순서로 분류되었다. 사회복지시설 직장 내 괴롭힘 극복요인의 범주는 ‘인간관계를 통한 지지’, ‘사회적 제도를 통한 주도적인 대처’, ‘사회복지 관련 업무에서의 탈피’, ‘사회복지업무를 지속하기 위한 개인적 노력’, ‘심리적 안정을 위한 재충전 및 자기 계발’, ‘나를 보호하기 위한 일시적 자기방어’의 순서로 분류되었다. 결론 본 연구는 사회복지종사자들의 직장 내 괴롭힘에 따른 어려움과 극복요인을 실제 경험을 토대로 공통적인 요인을 도출해 내고 요인들을 심리적⋅사회적 구조 차원에서 구조화하고 이를 검증하였다는 의의가 있다. Objectives The purpose of this study is to study the difficulties associated with workplace bullying and the factors for overcoming workplace bullying perceived by social workers in social welfare facilities by using the “Concept Map Study Method”. In addition, what factors were in overcoming the difficulties caused by workplace bullying were investigated. Methods Individual interviews were conducted with 10 social workers who had experienced workplace bullying within the past 5 years, and 79 key sentences related to difficulties and 62 key sentences related to overcoming factors were derived. Next, the level of sympathy for the difficulties caused by bullying in the workplace at social welfare facilities and the level of importance of overcoming factors in workplace bullying in social welfare facilities were analyzed. Based on these data, ‘Multidimensional scaling; MDS’ and ‘Hierarchical cluster analysis; HCA’ were conducted. Results As a result of the analysis, the categories of difficulties caused by workplace bullying in social welfare facilities were ‘decline in trust in social welfare facilities and public institutions’, ‘cynic changes in the world and social welfare facilities’, ‘psychological pain and negative emotions’, ‘isolation and exclusion’, ‘relational harassment of managers and colleagues’, ‘symptoms of mental and physical problems and difficulties in daily life’, ‘intentional and subtle bullying’, and ‘disadvantages at work’. The categories of factors to overcome bullying in social welfare facilities are ‘support through interpersonal relationships’, ‘initiative coping through social systems’, ‘abandonment from work related to social welfare’, and ‘personal effort to continue social welfare work’, ‘recharge and self-development for psychological stability’, and ‘temporary defense measures to protect oneself’. Conclusions This study is meaningful in that it deduced common factors based on actual experiences on the difficulties and overcoming factors caused by workplace bullying of social welfare workers.
( Minkyoung Kim ),( Jae Hoon Lee ),( Jung Mi Yoon ),( Ah Leum Kim ),( Seok Kyo Seo ),( Sihyun Cho ),( Young Sik Choi ),( Byung Seok Lee ),( Bo Hyon Yun ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: The aim of the study was to examine the inflammatory status of follicular fluid in endometriosis by detecting High mobility group box-1 (HMGB-1) and inflammatory cytokines, which reflect the milieu of oocyte that may play a role for infertility. 방법: Total 60 patients who had received in vitro fertilization and embryo transfer (IVF-ET) from March, 2013 to March, 2016 were included: 30 patients who had endometriosis as case group, 30 participants without endometriosis as the control. Follicular fluid (FF) was obtained from a dominant follicle during oocyte retrieval and stored at -70°C. Level of HMGB-1 was measured with ELISA, as well as inflammatory cytokines including Interleukin (IL)-1β, IL-6, IL-8, and tumor-necrosis factor (TNF)-α. 결과: Level of HMGB-1 was significantly higher in FF samples from the endometriosis group compared to the controls. IL-6, IL-8, and TNF-α levels were significantly higher in the endometriosis group compared to those in the control. There were significant positive correlations among the four inflammatory cytokines. The levels of the inflammatory cytokines positively correlated with the levels of HMGB-1 in the FF samples. TNF-α levels were negatively correlated with the cumulative embryo score per embryo. Logistic regression analysis revealed that the number of high-quality embryos was an independent factor predicting clinical pregnancy. 결론: This study showed that HMGB-1 and inflammatory cytokines may play an important role through NF-kB pathway, in inflammatory cascade affecting oocyte milieu.