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Anti-Cancer Effects of Phytochemical A against B16F10 Melanoma Cells
Minjoo Han,Seong-Ah Shin,Gyoungah Ryu,Huiji Kim,Jangeun An,Chang Sup Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Melanoma is one of the most common cancer worldwide and is an aggressive form that accounts for most of the deaths of patients with skin cancers. If the invasion of melanoma has occurred, it is hard to be cured and can be life-threatening. Phytochemicals are the metabolic compounds that were found in plants. It has already been known to prevent various chronic diseases including cancer. The chemical “A” is the phytochemical which is one of the isoflavones that are known to inhibit tumor growth and limit the production of cancer-related hormones. We focused on the anti-cancer effects of the phytochemical A that play important roles in B16F10 melanoma cells. The phytochemical A reduced cell viability and cell numbers. We also found that these effects are because of the inhibition of proliferation rather than cytotoxicity. In addition, the phytochemical A induced cell cycle arrest at the G0/G1 phase and inhibited the migration of melanoma cells. Taken together, these results suggest that phytochemical A could exert its effect against metastasis and the cell cycle in melanoma cells. Therefore, it implies that it could work as a chemotherapeutic agent for cancer treatment.
이민주(Minjoo LEE),김철환(Chulhwan KIM),장태순(Taesun CHANG),강혜진(Hyejin KANG) 한국소음진동공학회 2016 한국소음진동공학회 학술대회논문집 Vol.2016 No.4
The aim of this study is to examine the traffic noise levels (dBA) by the conditions of noise barriers in the apartment building. Two sets of case studies for determining traffic noise reduction by sound analysis software are performed. The first case study is investigated that the arrangements of noise absorption panel are composed of the 30% area of the lower, middle, and upper parts on the noise barrier, and they are given the absorption coefficient of 70 %. The second case study is about areas of panel which are located the lower part composed areas of 20, 30, and 50 %. The results show that the lower part of panel is effective for a reduction of traffic noise. On the other hand, there are not big difference each absorption areas. In conclusion, the arrangement of noise absorption panel is more critical to reduce the traffic noise than adapting absorption area on the noise barrier.
Insil Joung,Minjoo Yoo,Ji Hyoun Woo,Chi Young Chang,Hwon Heo,김윤희 한국분자세포생물학회 2010 Molecules and cells Vol.30 No.5
Neuregulin 1 (NRG1) and epidermal growth factor receptor (ErbB) signaling pathways control Schwann cells during axonal regeneration in an injured peripheral nervous system. We investigated whether a persistent supply of recombinant NRG1 to the injury site could improve axonal growth and recovery of sensory and motor functions in rats during nerve regeneration. We generated a recombinant adenovirus expressing a secreted form of EGF-like domain from Heregulinβ (sHRGβE-Ad). This virus, sHRGβEAd allowed for the secretion of 30-50 ng of small sHRGβE peptides per 107-8 virus particle outside cells and was able to phosphorylate ErbB receptors. Transduction of the concentrated sHRGβE-Ad into an axotomy model of sciatic nerve damage caused an effective promotion of nerve regeneration, as shown by histological features of the axons and Schwann cells, as well as increased expression of neurofilaments, GAP43 and S100 in the distal stump of the injury site. This result is consistent with longer axon lengths and thicker calibers observed in the sHRGβE-Ad treated animals. Furthermore, sensory and motor functions were significantly improved in sHRGβE-Ad treated animals when evaluated by a behavioral test. These results suggest a therapeutic potential for sHRGβE-Ad in treatment of peripheral nerve injury.
Controlled growth of perovskite microplates arrays for functional optoelectronics
Choi Won Young,Chang Won Jun,Jang Suhee,Kim Minjoo,Park Won Il 한국물리학회 2022 Current Applied Physics Vol.37 No.-
In this study, a novel and facile route was utilized to synthesize methylammonium lead iodide (MAPbI3) perovskite microplate arrays with uniform morphology and predefined locations. Initially, large-area singlecrystalline lead iodide (PbI2) thin sheets were synthesized through a solvent evaporation crystallization method for synthesizing PbI2 thin sheets. These PbI2 sheets were then employed as a seed layer to grow uniaxially aligned arrays of PbI2 microplates through lithographically defined microscale windows in a polymeric film. Thereafter, the PbI2 microplates were further intercalated with methylammonium iodide (MAI) to produce perovskite crystals. Structural and optical characterizations showed that the synthesized materials have a distinct heterojunction structures consisting of MAPbI3 perovskite microplates arrays and the underlying PbI2 thin sheet layer. The two-step process reported herein, which involves the uniaxial growth of PbI2 microplates and their conversion to MAPbI3 perovskite microplates with little dimensional change offers a new pathway for the fabrication of materials for integrated electronic and optoelectronic systems.
Afrormosin exerts an anticancer effect via MAPK and AKT signaling pathways in B16F10 cells
Kim Huiji,Han Minjoo,Shin Seong-Ah,An Jangeun,Ahn Mi-Jeong,Lee Jun Hyuck,Park Hyun Ho,Lee Chang Sup 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.6
Melanoma is a deadly skin cancer with high mortality, and its incidence is increasing every year. Although numerous anticancer drugs have been developed, these treatments have various side effects, such as skin rash, fatigue, diarrhea, cough, and muscle pain. Therefore, there is a need for research on novel anticancer drugs with low cytotoxicity and few side effects. In this study, we investigated whether afrormosin (7-hydroxy-4′,6-dimethoxyisoflavone), a member of the isoflavonoid family, could have the potential as a novel anticancer drug. Afrormosin decreased the viability of B16F10 melanoma cells in a time- and dose-dependent manner. We also found that the afrormosin-induced decrease in cell viability was caused by the reduction of cell proliferation through Go/G1 arrest and the induction of apoptosis in B16F10 melanoma cells. Furthermore, afrormosin decreased the metastatic activity (cell invasion and migration) of B16F10 melanoma cells. At the molecular level, afrormosin reduced the levels of Bcl-2, an anti-apoptotic protein, and augmented the levels of Bax, a pro-apoptotic protein, and p53, a tumor suppressor. Additionally, procaspase-3 levels were reduced by afrormosin treatment. When we examined the signaling pathways affected by afrormosin, we found that the AKT/ERK pathways were inhibited and the p38/JNK pathway was activated by afrormosin. Collectively, these results suggest the potential anticancer effect of afrormosin, making it a prospective candidate for development as an anticancer drug.
Virulence of a novel reassortant canine H3N2 influenza virus in ferret, dog and mice models
( Woonsung Na ),( Kwang-soo Lyoo ),( Minjoo Yeom ),( Dae-gwin Jeong ),( Daesub Song ),( Chang-ung Kim ),( Jeong-ki Kim ),( Daesub Song ) 대한인수공통전염병학회 2016 창립총회 및 학술대회 초록집 Vol.2016 No.1
The outbreak of a canine influenza virus (CIV) H3N2 reassortanted from pandemic (pdm) H1N1 and CIV H3N2 in companion animals has underscored the urgent need to monitor CIV infection for potential zoonotic transmission of influenza viruses to humans. In this study, we assessed the virulence of a novel CIV H3N2 (VC378) from a pdm H1N1 and CIV H3N2 coinfected dog in ferrets, dogs, and mice. Significantly enhanced virulence of VC378 was demonstrated in mice, although the transmissibility and pathogenicity of VC378 were similar to those of classic H3N2 in ferrets and dogs. This is notable because mice inoculated with an equivalent dose of classic CIV H3N2 showed no clinical signs and no lethality. We found that the PA and NS gene segments of VC378 were introduced from pdmH1N1, and these genes included amino acid substitutions; PAP224S and NS-I123V, that were previously found to be associated with virulence enhancement in mice. Thus, we speculate that the natural reassortment of CIV between pdm H1N1 and CIV H3N2 can confer virulence and that continuous surveillance is needed to monitor the evolution of CIV in companion animals.