Extract of high hydrostatic pressure-treated danshen (Salvia miltiorrhiza) ameliorates atherosclerosis via autophagy induction

( Minjeong Ko ),( Goo Taeg Oh ),( Jiyong Park ),( Ho Jeong Kwon ) 생화학분자생물학회 2020 BMB Reports Vol.53 No.12

Danshen (Salvia miltiorrhiza) is a traditional medicinal plant widely used in Asian countries for its pharmacological activities (e.g., amelioration of cardiovascular diseases). In this study, we investigated the anti-atherosclerotic activity of raw danshen root extract prepared using high hydrostatic pressure (HHP) at 550 MPa for 5 min and hot water extraction. This method was useful for elimination of bacteria from cultured danshen plants and for better extraction yield of active principles. The HHPtreated danshen extract (HDE) inhibited proliferation of human umbilical vein endothelial cells (HUVECs) and induced autophagy that was assessed by LC3 conversion and p62 degradation. HDE suppressed foam cell formation in oxLDL-induced RAW264.7 macrophages; lysosomal activity simultaneously increased, measured by acridine orange staining. HDE also reduced atherosclerotic plaque development in vivo in apolipoprotein E knock-out (ApoE^-/-) mice fed a high cholesterol diet. Taken together, these results indicated that HDE exhibited anti-atherosclerotic activity via autophagy induction. [BMB Reports 2020; 53(12): 652-657]

Research on developing smart phone contents for the elderly

Ko Minjeong,Lee Gunwoong,Choi Huisoo 한국콘텐츠학회 2017 한국콘텐츠학회 ICCC 논문집 Vol.2017 No.12

Comparison of Soviet Aid to North Korea and North Vietnam in the 1950s and 1960s

Minjeong Ko 이화여자대학교 통일학연구원 2019 Journal of peace and unification Vol.9 No.2

The purpose of this study is to compare Soviet aid to North Korea (DPRK) in the 1950s and 1960s with Soviet aid to North Vietnam (DRV) during the same period. With the data collected from various sources, this study compares the aid and identifies the meaning of it from the perspectives of patron-client state relationships. Relatively, more aid was given to North Korea in the mid-1950s and more to North Vietnam in the late- 1960s and both countries were given similar aid in the late 1950s and early 1960s. This was due to the fluctuation in the strategic value of the two countries to the Soviet Union particularly by the confrontations with the US-supported respective southern states and the compliance behavior of the recipient countries.

COVID-19 치료제로서 렘데시비르의 유효성 및 안전성에 대한 문헌고찰

고민정(Minjeong Ko),김유리(Youree Kim),민진기(Jingi Min),박민정(Minjeong Park),윤소정(So-Jung Yoon),최성아(Seong-A Choe),유봉규(Bong Kyu Yoo) 대한약학회 2021 약학회지 Vol.65 No.2

Remdesivir is a nucleotide analog that demonstrates antiviral activity by decreasing viral RNA production inside the host cells. In this literature review, we aimed to evaluate the efficacy and safety of remdesivir in the treatment of COVID-19. A total of 168 articles were identified in the Pubmed and Embase databases. Six clinical trial articles (two placebo-controlled and four open-labeled) and two re-analysis articles were selected for this review. Evaluation of efficacy in the two placebo-controlled prospective trials showed contradictory results. However, re-analysis of the clinical trials revealed that remdesivir was significantly effective in treating moderately severe COVID-19, while it failed to be effective in the treatment of the critically ill patient subgroup, requiring invasive mechanical ventilation. To treat moderately severe COVID-19 disease, a 5-day treatment is recommended since there was no significant difference between the 5-day and 10-day regimens. Severe adverse events were more frequently reported in the placebo group than in the remdesivir group because adequate COVID-19 treatment was not provided to the placebo group. Although remdesivir is a single option in the treatment of COVID-19 currently, clinicians should be aware of the risk of possible fatal side effects that have not yet been reported. Further studies are warranted to establish the efficacy and safety of remdesivir in the treatment of COVID-19.

시니어를 위한 노인놀이터의 개념과 유형

고민정(Ko Minjeong),이건웅(Lee Gunwoongg),김상헌(Kim SangHeon) 한국콘텐츠학회 2018 한국콘텐츠학회 종합학술대회 논문집 Vol.2018 No.5

콘텐츠명의 개념적 유창성이 콘텐츠 호감에 미치는 효과 : 정보처리성향의 조절효과를 중심으로

고민정(Minjeong Ko),이루리(Luri Lee),김규리(Qurie Kim) 한국콘텐츠학회 2021 한국콘텐츠학회논문지 Vol.21 No.9

국내 콘텐츠 시장은 꾸준히 성장해왔다. 이에 더해 코로나 19를 기점으로 콘텐츠 소비량이 급속도로 증가하였다. 따라서 콘텐츠 관련 소비자 행동에 대한 심층적 고찰이 필요하다. 이에 본 연구는 콘텐츠에 대한 소비자의 흥미를 유발하는 핵심요인으로서 콘텐츠명에 주목하였다. 콘텐츠명의 개념적 유창성(conceptual fluency)이 콘텐츠에 대한 호감도(liking)에 미치는 영향력을 실험을 통해 확인하였으며, 또한 소비자의 정보처리성향(언어적 vs. 시각적)을 조절변수로 제시하고 그 효과를 검증하였다. 분석 결과, 개념적 유창성이 높을 때 소비자는 콘텐츠에 대해 더 호의적인 반응을 보였으며, 소비자의 언어적 정보처리성향과 콘텐츠명의 개념적 유창성 간에는 유의한 상호작용 효과가 나타났다. 본 연구는 콘텐츠에 대한 소비자 호감도를 높이는 전략에 대해 고찰하고 있다. 특히, 정보처리성향이라는 소비자 특성 변수에 대한 효과를 검증하였다는 점에서 학문적, 실무적 의의가 있다. The domestic content market has grown continuously. Furthermore, content consumption has rapidly increased in the COVID-19 era. For these reasons, it is necessary to investigate consumer behavior related to content business. This study focuses on content names as a key factor that induces consumers interest in the content. In particular, this research examines if the conceptual fluency of the content name affects consumers liking for the content. In addition, it explores the moderating effect of style of information processing (verbalizer vs. visualizer). The results of an experiment shows that the conceptual fluency on the content name is positively influential for liking content. Also, there was a significant interaction effect between verbalizers and conceptual fluency on content name. This study has important findings in terms of content marketing strategies. Above all, it has strong points because this research examines the style of information processing as an important consumer characteristic variable.

디스플레이 표면 외광 반사에 따른 컬러 어피어런스 변화

고민정(Minjeong Ko),곽영신(Youngshin Kwak),오세민(Semin Oh),서영준(Youngjun Seo),김효선(Hyosun Kim) 한국색채학회 2020 한국색채학회 학술대회 Vol.2020 No.5

서로 다른 두 개의 LCD에서의 CIE 색도 불일치 - 메타메리즘 현상을 중심으로

고민정(Ko, Minjeong),곽영신(Kwak, Youngshin) 한국색채학회 2023 한국색채학회 논문집 Vol.37 No.1

Recently, various studies have observed the phenomenon that the two colors having the same CIE 1931 XYZ tristimulus values on two different displays are perceived as different colors. This study conducted a color matching experiment at a 4° viewing angle using two LCD displays with different spectral characteristics followed. Participants performed three color matching experiments: two adjustment methods and one color selection method. The results showed that although there was an observer variability of 2.78±1.96 △E<SUB>00</SUB>, it was confirmed that the CIE colorimetric mismatch magnitude was approximately twice as large as the observer variability magnitude; 5.49±2.27 △E<SUB>00</SUB>. Based on the color matching experiment results, the color appearance experiment which evaluates hue and color difference was conducted. The results showed that the results of the color matching experiment and the color appearance experiment were consistent. For the colors matched by each individual, the participants responded that colors were neutral colors which felt a little or no hue, and the color difference with the reference stimulus was low. This study confirmed that CIE 1931 color matching function failed to explain the color matching results, and research on new color matching functions considering human physiological characteristics is needed.

컴포넌트 기반 WAP 응용 자동 생성기의 구현

고민정(Minjeong Ko),강이지(Izzy Kang),이성혜(Sunghye Lee),박은희(Eunhee Park),음두헌(Doohun Eum) 한국정보과학회 2003 한국정보과학회 학술발표논문집 Vol.30 No.2Ⅱ

모바일 기반 전자상거래 시장이 급성장해 2004년 아시아 시장에서는 80억 달러를 넘어설 것으로 예상된다. 이렇게 급증하는 모바일 전자 상거래의 수요에 맞게 신속한 서비스를 제공하기 위해 WAP 응용의 생산성 향상이 요구된다. 본 논문에서 소개하는 WAPSiteGen은 데이터베이스부터 구축해야 하는 WAP 응용과 기존 데이터베이스를 사용하는 WAP 응용의 신속한 작성을 위해, 무선 응용의 사용자 인터페이스로 사용되는 WML 데크들과 함께 이 데크를 구성하는 카드를 통해 이뤄질 질의를 처리하는 JSP 웹 컴포넌트 및 EJB 컴포넌트들을 자동 생성하여 WAP 응용의 생산성 향상을 지원하는 도구이다. WAPSiteGen은 EJB 및 JSP 컴포넌트 기술을 도입함으로써 3-계층 구조를 갖는 WAP 응용의 확장성, 재사용성, 이식성 등을 향상시킨다. 또한, 비슷한 기능을 지원하는 타 상용 도구들과 달리 WAPSiteGen이 생성하는 응용은 질의의 대상인 개체와 이 개체와 연관된 모든 개체들의 집합을 한 단위로 검색 할 수 있어 연관된 정보들을 신속하게 제공할 수 있다.

텍스트 마이닝을 활용한 코로나 19 전후 온라인 동영상 서비스(OTT) 리뷰 비교분석 연구 – 정서 중심 대처와 노스탤지어를 중심으로

고민정(Minjeong Ko),이상원(Sangwon Lee) 한국콘텐츠학회 2021 한국콘텐츠학회논문지 Vol.21 No.11

본 연구에서는 팬데믹 전후로 온라인 동영상 서비스(OTT) 이용자들의 리뷰를 비교분석 함으로써 코로나 19 시대를 살아가는 소비자에 대한 이해에 기여하고자 하였다. 코로나 19 이후 통제감 상실이 회피 동기의 발현으로 이어져 정서 중심 대처 수단으로써의 OTT 서비스 이용과 노스탤지어를 해소해주는 콘텐츠에 대한 관심이 증가할 것으로 보고 이를 텍스트 분석을 통해 검증하였다. 먼저 블로그 제목 분석결과, 코로나 19 이후 넷플릭스 경쟁사에 대한 언급이 줄었으며, 국내 콘텐츠에 대한 소개와 회피-거부 전략으로써의 OTT 서비스 이용이 증가하였다. 이어 블로그 본문 분석결과, OTT 서비스의 실용적인 장점을 중요시한 코로나 19 전과는 달리 코로나 19 이후 콘텐츠의 분위기, 감정, 대사에 초점을 두었으며 코미디와 로맨스 장르에 대한 관심이 증가했다. 또한, 코로나 19 이전의 현실을 잘 표현한 일상 콘텐츠에 대한 선호가 증가하였다. 본 연구는 코로나 19가 온라인 동영상 서비스 이용에 미치는 영향을 처음으로 살펴본 연구로써 코로나 시대의 OTT 서비스 이용자들에 대한 이해를 넓히고 OTT 서비스 시장에 실무적 제언을 제시함으로써 도움을 줄 수 있을 것으로 기대한다. This study aims to contribute to the understanding of consumer behavior during the COVID-19 by comparing blog reviews of an over-the-top (OTT) online video service from before and during the pandemic. We anticipate that the COVID-19 outbreak prompts the use of the OTT service as part of an emotion-focused coping strategy derived from the loss of personal control and the subsequent avoidance motivation. We also posit that a strong yearning for life before COVID-19 will increase interest in the content that fulfills a need for nostalgia. Our analysis of Netflix reviews provides empirical evidence of the effects of an emotion-focused coping strategy and nostalgia on OTT service usage. First, the titles of the reviews posted during COVID-19 indicate that consumers were less likely to mention OTT services other than Netflix, more interested in domestic content, and used OTT services as an avoidance-denial strategy. Second, the blog content demonstrates that while pre-COVID reviews tend to focus on the practical benefits of OTT services, those posted during the pandemic focus on mood, emotions, and dialogue. In addition, interest in comedy and romance genres increased during COVID-19. Third, we identified a greater preference for realistic or everyday content that depicted the pre-pandemic era. This is the first empirical study to investigate the effects of COVID-19 on video streaming usage in Korea. In addition, this research contributes to the field of marketing by expanding our understanding of online video service users during COVID-19 and identifies practical implications for OTT services in the midst of a pandemic.