충남지역 S대학의 중앙도서관과 휴게시설의 총부유분진 및 총부유세균 농도 연구

이서빈,김지욱,임채령,이정민,정소진,이민혁,손부순 순천향대학교 기초과학연구소 2021 순천향자연과학연구 논문집 Vol.27 No.1.2

The average indoor concentration of the library's TSP was 0.03 ng/m³. TAB in library and lounge in college of engineering showed higher concentrations in corridors than indoors. The correlation coefficient between TAB and humidity is 0.985, so it is judged that there is a significant need for humidity control in indoor air quality management to reduce the concentration of total suspended bacteria(p<0.01).

Outcomes and Complications of Oblique Lateral Interbody Fusion as a Surgical Option in Elderly Patients (Over 70 Years Old) with Degenerative Spinal Disease

Lee Yong Min,Son Dong Wuk,Oh Bu Kwang,Lee Su Hung,Lee Jun Seok,Kim Young Ha,Sung Soon Ki,Lee Sang Weon,Song Geun Sung 대한말초신경학회 2023 The Nerve Vol.9 No.2

Objective: As Korea has become a super-aging society, the number of elderly patients with degenerative spinal disease has steadily increased. This study aimed to evaluate the usefulness of oblique lumbar interbody fusion (OLIF) by comparing the results and complications between OLIF and open spinal fusion in elderly patients with degenerative spinal disease.Methods: Thirty-one patients underwent one-level posterior lumbar interbody fusion (PLIF), and 35 patients underwent one-level indirect decompression OLIF. The clinical outcomes of the two patient groups were analyzed using the visual analog scale (VAS) and Oswestry Disability Index (ODI). Through a comparative analysis of pre- and post-operative images, we measured changes in disc height (DH) and foraminal height (FH), and investigated the occurrence of subsidence in each patient group. The cross-sectional area was measured using magnetic resonance imaging pre- and post-operatively in OLIF.Results: The pre-operative VAS and ODI scores were similar between the two groups and tended to improve post-operatively. In the OLIF group, the estimated blood loss (EBL) was significantly lower, DH and FH gains were more frequent, DH and FH maintenance was better, and cage subsidence occurred less frequently. In OLIF, psoas paresis and approach-site hematoma occurred; however, all patients with psoas paresis recovered without further treatment before discharge. In the PLIF group, dural tears occurred in four patients who recovered without revision surgery. Conclusion: OLIF enables indirect decompression, reduced EBL, shorter hospitalization, and lesser subsidence. OLIF is considered a beneficial, minimally invasive surgical method for elderly patients.

Real-world effectiveness of a single conventional disease-modifying anti-rheumatic drug (cDMARD) plus an anti-TNF agent versus multiple cDMARDs in rheumatoid arthritis: a prospective observational study

( Min Wook So ),( Sang-hyon Kim ),( Dong Wook Kim ),( Yoon-kyoung Sung ),( Jung-yoon Choe ),( Sang-il Lee ),( Jin-wuk Hur ),( Hye-soon Lee ),( Sang-heon Lee ),( Jin Ran Kim ) 대한류마티스학회 2024 대한류마티스학회지 Vol.31 No.2

Objective: The objective of this prospective, observational multicenter study (NCT03264703) was to compare the effectiveness of single conventional disease-modifying anti-rheumatic drug (cDMARD) plus anti-tumor necrosis factor (TNF) therapy versus multiple cDMARD treatments in patients with moderate-to-severe rheumatoid arthritis (RA) following cDMARD failure in the real-world setting in South Korea. Methods: At the treating physicians’ discretion, patients received single cDMARD plus anti-TNF therapy or multiple cDMARDs. Changes from baseline in disease activity score 28-joint count with erythrocyte sedimentation rate (DAS28-ESR), corticosteroid use, and Korean Health Assessment Questionnaire (KHAQ-20) scores were evaluated at 3, 6, and 12 months. Results: Of 207 enrollees, the final analysis included 45 of 73 cDMARD plus anti-TNF and 91 of 134 multiple-cDMARD recipients. There were no significant between-group differences (BGDs) in ANCOVA-adjusted changes from baseline in DAS28-ESR at 3, 6 (primary endpoint), and 12 months (BGDs -0.18, -0.38, and -0.03, respectively). More cDMARD plus anti-TNF than multiple-cDMARD recipients achieved a >50% reduction from baseline in corticosteroid dosage at 12 months (35.7% vs 14.6%; p=0.007). Changes from baseline in KHAQ-20 scores at 3, 6, and 12 months were significantly better with cDMARD plus anti-TNF therapy than with multiple cDMARDs (BGD -0.18, -0.19, and -0.19 points, respectively; all p≤ 0.024). Conclusion: In the real-world setting, relative to multiple cDMARDs, single cDMARD plus anti-TNF therapy significantly improved quality-of-life scores and reduced corticosteroid use, with no significant BGD in disease activity, in RA patients in whom previous cDMARD therapy had failed.

Characterization of physiologic 18F-FDG uptake with PET-CT in dogs.

Lee, Min-Su,Lee, Ah-Ra,Jung, Mi-Ae,Lee, In-Hye,Choi, Ji-Hye,Chung, Hyun-Woo,Jeong, Soon-Wuk,Nahm, Sang-Soep,Eom, Ki-Dong The College 2010 Veterinary Radiology and Ultrasound Vol.51 No.6

<P>We evaluated the whole body distribution of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) in seven beagle dogs using positron emission tomography/computed tomography. The mean and maximum standard uptake values (SUV) for various tissues were computed. The SUV of the aortic blood pool was 0.65 +/- 0.19. Moderate uptake was present in brain (3.40 +/- 1.01). Mild uptake was present in orbital muscles, soft palate, laryngeal and pharyngeal region, mandibular salivary gland, myocardium, liver, pancreas, kidney, and intestine. 18F-FDG uptake would be normally higher in these tissues because of normal physiologic activity. Mean and maximum SUV values of the eye, skeletal muscle, bone tissue, spleen, adrenal gland, stomach, tongue, gall bladder, and lung were similar to or lower than that of the aortic blood pool. These data provide a normal baseline for comparing pathologic 18F-FDG uptake.</P>

A Rare Case of Hypertrophic Pachymeningitis after Surgery for Chronic Subdural Hemorrhage: A Case Report

Lee Yong Min,이치형,Kim Chang Hyeun,Kim Young Ha,Sung Soon Ki,Son Dong Wuk,Lee Sang Weon,Song Geun Sung 대한말초신경학회 2023 The Nerve Vol.9 No.2

Hypertrophic pachymeningitis (HP) is a rare type of inflammatory fibrosis characterized by diffuse thickening of the dura mater, which may cause a compressive effect or vascular compromise. Progressively worsening headache is the usual symptom, along with ataxia and various cranial nerve palsies. This article describes a rare case of HP after burr hole trephination for a chronic subdural hemorrhage (CSDH). A 64-year-old man was admitted to the emergency room with a headache that had started approximately 2 weeks prior. After the diagnosis of CSDH on imaging, burr hole trephination was performed. Six months later, the patient visited the hospital again with a headache. He was diagnosed with a recurrence of CSDH, and a craniotomy was performed. A solid subdural granuloma was suspected and a pathological examination revealed acute and chronic inflammation. Tissue biopsy and laboratory blood tests did not reveal any abnormalities. Three months later, he visited the hospital again with a severe headache. Magnetic resonance imaging showed no significant difference in the area of the previous operation; however, focal venous congestion and localized venous ischemic or inflammatory changes were observed in the tentorium. A craniotomy was performed for biopsy, and the dura mater was very thick. The pathology was diagnosed as HP. After taking steroids and immunosuppressive agents, the patient's symptoms improved. HP is a rare chronic inflammatory condition of the dura mater that causes neurological deficits. If the diagnosis is not definitively established based on an imaging examination, it should be made through a surgical biopsy. Steroid and immunosuppressive agents can improve the prognosis after diagnosis.

Structure–activity relationships of novel quinazoline derivatives with high selectivity for HER2 over EGFR

Jung Wuk Lee,Changyu Choi,Jihyung Kim,Sohee Lee,Jina Kim,Yoonji Lee,Kyung Hoon Min 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.3

The gene amplifi cation of human epidermalgrowth factor receptor 2 (HER2) plays an essential role in theproliferation and progression of several cancers. However,HER2 inhibitors such as lapatinib strongly suppress wildtypeEGFR, resulting in severe adverse eff ects. Therefore,there is an unmet need for highly selective HER2 inhibitors. In this study, we describe the design and synthesis of novelquinazoline derivatives that exhibit enhanced selectivity forHER2 over wild-type EGFR. Structure–activity relationshipanalysis indicated that the selectivity for HER2 over EGFRdepends on the aniline moiety at C-4 and the substituentsat C-6 in the quinazoline derivatives. Compound 7c withan IC 50 of 8 nM for HER2 exhibited signifi cantly higherselectivity for HER2 over EGFR, with a 240-fold improvementover lapatinib. In addition, the synthesized compoundsexhibited anti-proliferative activity in the nanomolar rangeagainst SKBR3, a human breast cancer cell line that overexpressesHER2.

Result of Internal Fixation for Stable Femoral Neck Fractures in Elderly Patients

( Byung Woo Min ),( Kyung Jae Lee ),( Ki Cheor Bae ),( Si Wuk Lee ),( Seok Jung Lee ),( Jung Hoon Choi ) 대한고관절학회 2016 Hip and Pelvis Vol.28 No.1

Purpose: This study was conducted to evaluate the results of internal fixation for stable femoral neck fractures occurring in patients over 65 years old. Materials and Methods: Between 2008 and 2014, we evaluated 25 patients over 65 years old with Garden type 1 and 2 femoral neck fractures that were treated with internal fixation after a minimum follow up of 1 year. There were 5 males and 20 females and the average age was 72.3 years (range, 65-84 years) at the time of surgery. Fracture site union, horizontal shortening and complications were evaluated as radiographic parameters and change of walking ability (as measured using Koval walking ability score) was investigated as a clinical parameter. Results: Union of fracture site was achieved in 24 out of the 25 cases (96.0%). The average length of horizontal shortening was 6.5 mm (range, 0.2-19.7 mm). At final follow up, 3 cases experienced complications: nonunion (n=1), avascular necrosis (n=1), and subtrochanteric fracture after minor trauma (n=1). Walking ability decreased an average of 1 step at the final follow up. Conclusion: Internal fixation for stable femoral neck fractures occurring in patients over 65 years showed satisfactory union rates. However, care should be taken with this technique given the possibility of decreased walking ability resulting from horizontal shortening.

Elongation and gravitropic responses of <i>Arabidopsis</i> roots are regulated by brassinolide and IAA

KIM, TAE-WUK,LEE, SUN MIN,JOO, SE-HWAN,YUN, HYE SUP,LEE, YEW,KAUFMAN, PETER B.,KIRAKOSYAN, ARA,KIM, SOO-HWAN,NAM, KYOUNG HEE,LEE, JUNE SEUNG,CHANG, SOO CHUL,KIM, SEONG-KI Blackwell Scientific Publications 2007 Plant, cell and environment Vol.30 No.6

<P>ABSTRACT</P><P>Exogenously applied brassinolide (BL) increased both gravitropic curvature and length of primary roots of <I>Arabidopsis</I> at low concentration (10<SUP>−10</SUP> M), whereas at higher concentration, BL further increased gravitropic curvature while it inhibited primary root growth. <I>BRI1-GFP</I> plants possessing a high steady-state expression level of a brassinosteroid (BR) receptor kinase rendered the plant's responses to gravity and root growth more sensitive, while BR-insensitive mutants, <I>bri1-301</I> and <I>bak1</I>, delayed root growth and reduced their response to the gravitropic stimulus. The stimulatory effect of BL on the root gravitropic curvature was also enhanced in auxin transport mutants, <I>aux1-7</I> and <I>pin2</I>, relative to wild-type plants, and increasing concentration of auxin attenuated BL-induced root sensitivity to gravity. Interestingly, IAA treatment to the roots of <I>bri1-301</I> and <I>bak1</I> plants or of plants pretreated with a BL biosynthetic inhibitor, brassinazole, increased their sensitivity to gravity, while these treatments for the BL-hypersensitive transgenic plants, <I>BRI1-GFP</I> and <I>35S-BAK1</I>, were less effective. Expression of a <I>CYP79B2</I> gene, encoding an IAA biosynthetic enzyme, was suppressed in BL-hypersensitive plant types and enhanced in BL-insensitive or -deficient plants. In conclusion, our results indicate that BL interacts negatively with IAA in the regulation of plant gravitropic response and root growth, and its regulation is achieved partly by modulating biosynthetic pathways of the counterpart hormone.</P>

최근 20년간 대구-경북 지역 피부악성종양에 관한 임상적 특징에 관한 고찰: 전반기 10년(1994∼2003)과 후반기 10년(2004∼2013)간 비교

이규채 ( Kyouchae Lee ),김민지 ( Min Ji Kim ),채수열 ( Soo Yuhl Chae ),차현욱 ( Hyun Wuk Cha ),장용현 ( Yong Hyun Jang ),이원주 ( Weon Ju Lee ),김도원 ( Do Won Kim ),이석종 ( Seok Jong Lee ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.7

Background: Although skin cancer incidence has recently increased, there has been little research into the incidence, clinical manifestations, and prognosis of skin cancers in Korea, especially in Daegu City and the Kyungpook Province. Objective: To analyze changes over the recent two decades in incidence and clinical patterns, including recurrence of skin cancers diagnosed at a university hospital in Daegu City. Methods: We reviewed 1,566 skin cancer cases from 1994 to 2013 at the Department of Dermatology in Kyungpook National University Hospital (KNUH). We also divided them into first (1994∼2003) and second group (2004∼2013) to examine changes over the years. Results: The average incidence of skin cancers among the total number of outpatients was 1.39% through whole study period including 0.38% in the first and 2.10% in the second decade. Basal cell carcinoma (BCC) was the most commonly diagnosed skin cancer (total:1st:2nd=0.60%:0.16%:0.91%), followed by squamous cell carcinoma (SCC) (0.43%:0.12%:0.65%) and malignant melanoma (MM) (0.22%:0.05%:0.34%). The most common skin cancer site was the face in each decade. The recurrence of three major skin cancers (BCC, SCC and MM) was diagnosed in 49 of the 1,402 patients (3.50%). In each disease, the recurrence rate (1st:2nd) was 1.64% (BCC, 4.11%:1.34%), 3.51% (SCC, 11.11%:2.55%), and 8.57% (MM, 4.35%:9.01%). Conclusion: This epidemiological study provided useful information about the incidence and prognosis of skin tumors in Korea, especially in Daegu City and Kyungpook Province. (Korean J Dermatol 2015;53(7):505∼514)

외전근 부전 환자에서 구속형 라이너를 이용한 인공 고관절 재치환술

이경재(Kyung-Jae Lee),민병우(Byung-Woo Min),배기철(Ki-Cheor Bae),손은석(Eun-Seok Son),이시욱(Si-Wuk Lee),이석중(Seok-Jung Lee),임경환(Kyung-Hwan Lim) 대한정형외과학회 2016 대한정형외과학회지 Vol.51 No.4

목적: 인공 고관절 재치환술 중 외전근 부전 소견을 보인 환자에서 구속형 라이너 사용 결과를 알아보고자 하였다. 대상 및 방법: 재치환술 중 외전근 부전 소견으로 구속형 라이너를 사용하고 2년 이상 추시 관찰이 가능하였던 30예를 대상으로 하였다. 남자 14예, 여자 16예였으며 평균 추시 기간은 4.6년이었다. 재탈구나 삽입물의 무균성 해리가 발생한 경우를 구속형 라이너의 실패로 정의하였다. 임상적으로 Harris 고관절 점수 및 보행능력을, 방사선적으로 골용해, 무균성 해리 및 기타 합병증의 발생 유무를 조사하였다. 결과: 추시 기간 중 구속형 라이너의 실패는 4예(13.3%)에서 발생하였으며 재탈구 2예, 비구컵 무균성 해리 2예였다. Harris 고관절점수는 술 전 평균 38.3점에서 술 후 평균 73.4점으로 향상되었으며, 최종 추시 시 보행능력의 호전을 보인 경우가 20예(66.7%)였다. 합병증으로 감염 1예, 삽입물 주위 골절 1예가 발생하였다. 결론: 인공 고관절 재치환술 시 외전근 부전 소견을 보이는 환자에서 구속형 라이너는 만족할 만한 재탈구 예방 효과를 보였으나 삽입물의 해리 등에 대한 좀 더 장기간의 연구가 필요할 것으로 생각된다. Purpose: The purpose of this study was to evaluate clinical and radiographic results of revision total hip arthroplasty with constrained liner in patients with abductor insufficiency. Materials and Methods: In this study, 30 patients treated with constrained liner during revision total hip arthroplasty due to abductor insufficiency were evaluated after minimum 2-year follow-up. There were 14 men and 16 women and the mean follow-up period was 4.6 years. Re-dislocation and aseptic loosening of the implant were defined as a failure of the constrained liner. Harris hip score and ambulatory function were evaluated as a clinical parameter and osteolysis, aseptic loosening of the implant and other complications were evaluated as a radiologic parameter. Results: During the follow-up period, there were 4 cases (13.3%) of constrained liner failure including two cases of re-dislocation and two cases of acetabular cup aseptic loosening. The average Harris hip score was improved from 38.3 points preoperatively to 73.4 points at last follow up. At the final follow-up, there were 20 cases (66.7%) of improvement in ambulatory function. There was 1 case of infection and 1 case of periprosthetic fracture. Conclusion: Use of a constrained liner during revision total hip arthroplasty showed satisfactory results for prevention of re-dislocation in patients with abductor insufficiency. However longer term studies on loosening of implants are needed.