Cancellable iris template generation based on Indexing-First-One hashing

Lai, Yen-Lung,Jin, Zhe,Jin Teoh, Andrew Beng,Goi, Bok-Min,Yap, Wun-She,Chai, Tong-Yuen,Rathgeb, Christian Elsevier 2017 Pattern Recognition Vol.64 No.-

<P><B>Abstract</B></P> <P>Eye iris has been widely recognized as one of the strongest biometrics attributed to its high accuracy performance. However, templates in conventional iris recognition systems are unprotected and highly vulnerable to numerous security and privacy attacks. Despite a number of cancellable biometric schemes have been proposed but at the expense of substantially decreased accuracy performance. In this paper, we introduce a new cancellable iris scheme, coined as “Indexing-First-One” (IFO) hashing. IFO hashing is inspired from the Min-hashing that primarily used in text retrieval domain. However, IFO hashing has been further strengthened by two novel mechanisms, namely P-order Hadamard product and modulo threshold function. The IFO hashing scheme strikes the balance between accuracy performance and privacy/security protection. Comprehensive experiments on CASIA-v3 iris benchmark database and rigorous analysis demonstrate decent accuracy performance with respect to its original counterparts yet offer strong resilience against several major security and privacy attacks.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new scheme to generate cancellable iris template with Jacaard similarity matcher. </LI> <LI> Modification of Min-hashing to strengthen the privacy security in IFO. </LI> <LI> IFO provides strong security and privacy against SHA, MHA, ARM, PIA attacks. </LI> <LI> IFO can be applied to variety of biometric feature with binary representation. </LI> </UL> </P>

동면동물 혈액상의 생리적 변화에 관한 연구

임영민,한현주,박래백,김효성,박경수,노영복 조선대학교 기초과학연구소 1990 自然科學硏究 Vol.13 No.1

활동기와 동면기에 동면동물인 살모사에 있어서 혈액내 가스함량과 부분압인 TCO_2, P0_2, PO_2 및 pH와 일반적인 혈액상인 적혈구수, 백혈구수, 혈색소, Hematocrit 등의 변화를 조사한바 다음과 같이 요약하였다. 1. 총이산화탄소량 (TCO_2), 이산화탄소부분압P(C0_2), 산소압(PO_2)과 pH는 활동기보다 동면기 에 증가하였다. 2. 적혈구수, 혈색소, 적혈구백분율(Hematocrit)은 활동기보다 동면기에 약간 증가하는 경향이었다. 3. 백혈구수는 활동기보다 동면기에 뚜렷한 감소를 보였다. 환경온도와 체온의 저하로 인한 혈액내의 변화는 인정할 수 있었다. This thesis were performed in order to study physiological changes of vipers in the active phase and hibernation phase, Physiological changes were blood gas volume and pressure (TCO_2, PCO_2, PO_2), blood pH and blood pictures (RBC, WBC, Hemoglobin, Hematocrit) The obtained results were summalize as follows; 1. TCO_2, PCO_2, PO_2 and pH increased considerably in hibernation phase, compared with active phase. 2. RBC, Hemoglobin and Hematocrit increased slightly in hibernation phase, compared with active phase. 3. WBC, decreased considerably in hibernation phase, compared with active phase 4. The decrease of environmental and body temperature showed change of blood components.

활동기 척추동물의 십이지장 배상세포내 점액질에 관한 조직화학적 연구

박래백,한현주,임영빈,김효성,박경수,노영복 조선대학교 기초과학연구소 1990 自然科學硏究 Vol.13 No.1

본 실험은 다람쥐(Tamias sibiricus asiaticus Gmeli), 살모사(Agkistrodon halys Pallas), 황소개구리(Rana catesbeiana Shaw), 뱀장어(Anguilla japonica Temminck et Schlegel)등의 소장 배상세포내 점액질에 대한 성상을 밝히기 위하여 PAS reaction, Alcian blue pH2.5 및 Alcian blue pH0.4, 그리고 ABpH2.5-PAS reaction 복합염색등을 시행한 결과 다음과 같은 결론을 얻었다. 1. 사용한 각 동물에 있어서 소장 배상세포는 중성점액질, 약산성 및 강산성 황화점액질을 포함하고 있었다. 2. 중성점액질이 각 동물에 있어서 가장 안정된 분포를 보였으며 약산성 황화점액질도 비교적 고르게 분포되어 있었다. 3. 강산성 황화점액질은 다람쥐, 살모사 및 황소개구리에서는 소량 관찰되어 불안정한 분포를 보였으며 뱀장어에서는 관찰되지 않았다. 4. 각 실험동물의 십이지장 배상세포내에 포함된 점액질의 성상은 동물에 따라서 그 양과 염색성에 다소의 차이를 인정할 수 있다. In general, the goblet cells in the small intestines of experimental animals contained neutral mucosubstances, weakly and strongly acidic sulfated mucosubstances. Neutral mucosubstances show most stable distribution in the experimental animals. Mucosubstances in the small intestines of eels were composed of only neutral mucosubstances and weakly acidic sulfated mucosubstances. The contents and stain properties of mucostances produced in the intestinal goblet cells vary a little in portions within a species and in the same cell types of different species. This studies were performed in order to study composition of the mucosubstance in the goblet cells of small intestines of the various vertebrates. The specimens used in this study were obtained from the small intestines of 4 species of vertebrates, squirrels (Tamias sibiricus asiaticus Gmelin), vipers (Agkistrodon halys Palls), frogs (Rana catesbeiana Shaw), eels (Anguilla japonica Temminck et Scchlegel). All specimens were fixed in 10% neutral buffered formalin, embedded in paraffin wax, and sectioned at a thickness of 4㎛. They were stained with hematoxylin-eosin for general histological observation and with Periodic Acid-Schiff reaction, alcian blue pH2.5 and 0.4 and alcian blue pH2.5-Periodic Acid-Schiff reaction for detection of the mucosubstances. The mucous compositions in the goblet cells of the small intestines of various vertebrates examined by their staining reaction were neutral mucosubstances, weakly and strongly acidic sulfated mucosubstances.

활동기와 동면기 살모사의 위장관 점액세포내 점액질에 관한 조직화학적 연구

한현주,박래백,임영민,김효성,박경수,노영복 조선대학교 기초과학연구소 1990 自然科學硏究 Vol.13 No.1

살모사(Aekistrodon halys Pallas)의 위장관 점액세포내 점액질을 활동기와 동면기로 나누어 조직화학적으로 비교관찰하였다. 일반관찰을 위하여 H-E 염색을, 조직화학적 소견을 관찰하기 위하여 PAS reaction, Ab2.5 염색, AB1.0염색, AB2.5-PAS 염색, AB1.0-PAS 염색 AF1.7 염색 및 AF1.7-AB2.5 염색등을 시행하였다. 위(胃)는 표면점액세포와 점액경세포의 점액질을, 소장은 은롸롸 융모의 점액세포를 관찰한 결과를 다음과 같이 요약하였다. 1. 활동기와 동면기의 위점막에서는 현저한 차이는 없으나, 소장점막은 동면기에는 점막 주름수가 감소하고 높이가 낮아지며 점액세포가 위축되었다. 2. 위 표면점액세포는 활동기에 중성점액질과 약간의 Sialomucin을 포함한 산성점액질로 구성되었으나, 동면기에는 중성점액질과 Sialomucin이 약간 감소하였다. 3. 위 점액경세포는 활동기에 중성점액질만을 포함하고 있었으나, 동면기에는 Sialomucin을 포함한 산성점액질이 소량 검출되었다. 4. 소장 점액세포는 활동기에 산성점액질과 중성점액질로 구성되었으며 산성점액질에는 Sulfomucin과 Sialomucin이 포함되어 있었으나, 동면기에는 Sulfomucin과 Sialomucin이 다소 감소하였다. This study was performed in order to investigate the histochemical properties and compositions of the mucosubstances in the mucous of the gastrointestinal tract of Vipers, Agkistrodon halys Pallas, in active and hibernating phases. The specimens from stomach and small intestine were fixed in 10% neutral buffered formalin, embedded in paraffin wax, sectioned at a thickness of 4㎛, and stained with Hematoxyling-eosin for general histological observation and with PAS reaction, Alcian blue pH 2.5 or 1.0, Alcian blue pH 2.5-PAS or 1.0-PAS reaction, Aldehyde fuchsin pH 1.7, and Aldeliyde fuchsin pH 1.7-Alcian Blue pH 2.5 for histochemical finding. The mucous compositions in mucous cells of the gastrointestinal tract examined by their stain reaction were neutral mucin, acidic mucin, sulfomucin, sialomucin, The results obtained were as follows; The folds of the gastrointestinal tract in the hibernating phase, compared with the active phase, shrink and lower. Also, the shrinkage of epithelial cells were observed in the hibenating phase. The surface mucous cells of the stomach in the active phase composed mainly neutral mucin and a little amount of acidic mucin including sialomucin, but in the hibernating phase neutral mucin and sialomucin slightly decreased. The mucous neck cells of the stomach in the active phase constituted mainly neutral mucin, In the hebernating phase the mucous neck cells were composed of neutral mucin and a little amount of acidic mucin contained sialomucin. The mucous cells of the small intestine in the active phase consist of neutral mucin, acidic mucin including sulfomucin and sialomucin but in the hibernating phase sulfomucin and sialomucin slightly decreased.

Oxidative stress-mediated TXNIP loss causes RPE dysfunction

Min Ji Cho,Sung-Jin Yoon,Wooil Kim,Jongjin Park,Jangwook Lee,Jong-Gil Park,Young-Lai Cho,Jeong Hun Kim,Hyejin Jang,박영준,이상현,Jeong-Ki Min 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

The disruption of the retinal pigment epithelium (RPE), for example, through oxidative damage, is a common factorunderlying age-related macular degeneration (AMD). Aberrant autophagy also contributes to AMD pathology, asautophagy maintains RPE homeostasis to ensure blood–retinal barrier (BRB) integrity and protect photoreceptors. Thioredoxin-interacting protein (TXNIP) promotes cellular oxidative stress by inhibiting thioredoxin reducing capacityand is in turn inversely regulated by reactive oxygen species levels; however, its role in oxidative stress-induced RPEcell dysfunction and the mechanistic link between TXNIP and autophagy are largely unknown. Here, we observed thatTXNIP expression was rapidly downregulated in RPE cells under oxidative stress and that RPE cell proliferation wasdecreased. TXNIP knockdown demonstrated that the suppression of proliferation resulted from TXNIP depletioninducedautophagic flux, causing increased p53 activation via nuclear localization, which in turn enhanced AMPKphosphorylation and activation. Moreover, TXNIP downregulation further negatively impacted BRB integrity bydisrupting RPE cell tight junctions and enhancing cell motility by phosphorylating, and thereby activating, Src kinase. Finally, we also revealed that TXNIP knockdown upregulated HIF-1α, leading to the enhanced secretion of VEGF fromRPE cells and the stimulation of angiogenesis in cocultured human retinal microvascular endothelial cells. Thissuggests that the exposure of RPE cells to sustained oxidative stress may promote choroidal neovascularization,another AMD pathology. Together, these findings reveal three distinct mechanisms by which TXNIP downregulationdisrupts RPE cell function and thereby exacerbates AMD pathogenesis. Accordingly, reinforcing or restoring BRBintegrity by targeting TXNIP may serve as an effective therapeutic strategy for preventing or attenuatingphotoreceptor damage in AMD.

A common evolutionary pathway for maintaining quorum sensing in Pseudomonas aeruginosa

Bai-min Lai,Hui-cong Yan,Mei-zhen Wang,Na Li,Dongsheng Shen 한국미생물학회 2018 The journal of microbiology Vol.56 No.2

In the bacterium Pseudomonas aeruginosa, the synthesis and secretion of extracellular protease is a typical cooperative behavior regulated by quorum sensing. However, this type of cooperative behavior is easily exploited by other individuals who do not synthesize public goods, which is known as the “tragedy of the commons”. Here P. aeruginosa was inoculated into casein media with different nitrogen salts added. In casein broth, protease (a type of public good) is necessary for bacterial growth. After 30 days of sequential transfer, some groups propagated stably and avoided “tragedy of the commons”. The evolved cooperators who continued to synthesize protease were isolated from these stable groups. By comparing the characteristics of quorum sensing in these cooperators, an identical evolutionary pattern was found. A variety of cooperative behaviors regulated by quorum sensing, such as the synthesis and secretion of protease and signals, were significantly reduced during the process of evolution. Such reductions improved the efficiency of cooperation, helping to prevent cheating. In addition, the production of pyocyanin, which is regulated by the RhlIR system, increased during the process of evolution, possibly due to its role in stabilizing the cooperation. This study contributes towards our understanding of the evolution of quorum sensing of P. aeruginosa.

Adsorptive Granulocyte and Monocyte Apheresis in the Treatment of Ulcerative Colitis: The First Multicenter Study in China

( Ya-min Lai ),( Wei-yan Yao ),( Yao He ),( Xuan Jiang ),( Yu-bei Gu ),( Min-hu Chen ),( Yu-lan Liu ),( Yao-zong Yuan ),( Jia-ming Qian ) 대한소화기학회 2017 Gut and Liver Vol.11 No.2

Background/Aims: Patients with active ulcerative colitis (UC) have elevated levels of activated myeloid-derived leukocytes as a source of inflammatory cytokines. The selective deple-tion of these leukocytes by adsorptive granulocyte/monocyte apheresis (GMA) with an Adacolumn should alleviate inflammation, promote remission and enhance drug efficacy. However, studies have reported contrasting efficacy out-comes based on patients` baseline demographic variables. This study was undertaken to understand the demographic features of GMA responders and nonresponders. Methods: This was a multicenter study in China involving four institutions and 34 patients with active UC. Baseline conventional medications were continued without changing the dosage. The treatment efficacy was evaluated based on the endo-scopic activity index and the Mayo score. Results: Thirty of the 34 patients completed all 10 GMA treatment sessions. The overall efficacy rate was 70.59%. The receiver operating characteristic analysis showed that the area under the curve was approximately 0.766 for a Mayo score of ≤5.5 with 0.273 specificity and 0.857 sensitivity (Youden index, 0.584) for GMA responders. No GMA-related serious adverse events were observed. Conclusions: The overall efficacy of GMA in patients with active UC who were taking first-line medications or were corticosteroid refractory was encouraging. Addition-ally, GMA was well tolerated and had a good safety profile. (Gut Liver 2017;11:216-225)

고추종자의 Solid Matrix Priming시 GA₃와 BA 첨가가 발아성에 미치는 영향

임종민(Jong Min Lim),조양래(Yang Rae Cho),조정래(Jeoung Lai Cho),강성모(Jeoung Lai Cho) 한국원예학회 2002 한국원예학회 학술발표요지 Vol.2002 No.3

Daclatasvir plus Asunaprevir in Interferon (± Ribavirin)- Ineligible/Intolerant Asian Patients with Chronic HCV Genotype-1b Infection

( Lai Wei ),( Mingxiang Zhang ),( Min Xu ),( Wan-Long Chuang ),( Wei Lu ),( Wen Xie ),( Zhansheng Jia ),( Guozhong Gong ),( Yueqi Li ),( Si Hyun Bae ),( Yong-Feng Yang ),( Qing Xie ),( Shumei Lin ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: The efficacy/safety of daclatasvir (pan-genotypic NS5A inhibitor) plus asunaprevir (NS3 protease inhibitor) in interferon (± ribavirin)- ineligible/intolerant patients with chronic HCV genotype-1b infection from mainland China, Korea and Taiwan was investigated in a phase 3, open-label study. Methods: Patients received daclatasvir 60 mg (tablet) once daily plus asunaprevir 100 mg (soft capsule) twice daily for 24 weeks. The primary endpoint was sustained virologic response at post-treatment Week 24 (SVR24). Results: This study treated 159 patients from mainland China (80%), Korea (11%) and Taiwan (9%), including patients with cirrhosis (33%), IL28B non-CC genotypes (40%), and aged ≥70 years (4%). SVR24 was achieved by 91% of patients (100% concordance with SVR12) and was similarly high in all subgroups, e.g. cirrhotic patients (90%), and in patients from mainland China (91%), Korea (94%) and Taiwan (87%). SVR24 was higher in patients without baseline NS5A (L31M/Y93H) resistance-associated variants (RAVs) (n=137/139 [99%]), regardless of the presence (98%) or absence (99%) of cirrhosis, and lower in patients with baseline NS5A RAVs (n=8/19 [42%]). All serious adverse events (AEs) (n=5/159 [3.1%]), grade 4 laboratory abnormalities (n=3/159 [1.9%]) and deaths (n=1/159 [0.6%]) that occurred on-treatment were unrelated to the study drugs; two patients discontinued due to AEs. Treatment was generally well tolerated regardless of cirrhosis status. Conclusions: Daclatasvir plus asunaprevir achieved a high SVR24 rate of 91%, rising to 99% in patients without baseline NS5A RAVs, and was generally well tolerated in cirrhotic and non-cirrhotic interferon (± ribavirin)-ineligible/intolerant patients with HCV genotype-1b infection from mainland China, Korea and Taiwan.

Effects of Continuous and Combined Application of N-P-K Chemical Fertilizers on EC and pH Values of Root Soil of Cucumber Grown in Solar Greenhouse

Min Wei,Tian lai. Li,Xiu feng. Wang,Yan dong. Yin,Hui Xu 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-