정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

The Korean Association of lnternal Medicine : Poster Session ; PS 1357 : Nephrology ; Age is the Strongest Effector for the Relationship between Estimated Glomerular filtration Rate and Coronary Artery Calcifi cation in Apparently Healthy Korean Adults

( Hyun Beom Chae ),( Eun Jung Rhee ),( Hae Jung Park ),( Min Kyung Lee ),( Won Seon Jeon ),( Se Eun Park ),( Cheol Young Park ),( Won Young Lee ),( Ki Won Oh ),( Sung Woo Park ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Cardiovascular disease (CVD) is a major clinical problem and the most common cause of morbidity and mortality in patients with chronic kidney disease (CKD). Coronary artery calcifi cation (CAC) is a potential mechanism that explains the association between renal function and cardiovascular mortality. We aimed to evaluate the association between renal function and CAC in apparently healthy Korean subjects. Methods: In 23,617 participants in the health screening program in Kangbuk Samsung Hospital health screening program from January 2010 to December 2011, estimated glomerular fi ltration rate (eGFR) was assessed by Cockcroft-Gault equation. Coronary artery calcium score (CACS) was measured by multi-detector computed tomography (MDCT). Subjects were divided into 3 groups according to the CKD Staging system with eGFR grade; stage 1: eGFR = 90 mL/min/1.73 m2, stage 2: eGFR 60-89 mL/ min/1.73 m2, stage 3: eGFR 30-59 mL/min/1.73 m2. Results: Mean age of the participants was 41.4 years, and mean eGFR was 103.6±21.7 mL/min/1.73 m2. Hypertension and diabetes were noted in 43.7% and 5.5% of the participants, respectively. eGFR showed weakly negative but signifi cant association with CACS in bivariate correlation analysis (r=-0.076, p<0.01). Mean CACS signifi cantly increased from CKD stage 1 to 3. The proportion of subjects who had CAC signifi cantly increased from CKD stage 1 to 3. Although odds ratio for CAC signifi cantly increased from stage 1 to 3 after adjustment for confounding factors, this signifi cance was inversed when age was included in the model. Age was the strongest factor that affects CAC. Conclusions: This study performed in young Korean subjects with relatively normal renal function, age was the mostly strongest effector on the association between eGFR and the degree of CAC.

韓國學生의 姿勢形成 調査硏究

蔡鴻遠,李敏炯,申榮吉,金基學,李秀川,金正子 慶北大學校 體育科學硏究所 1990 체육과학연구지 Vol.6 No.-

In order to study the postures of Korean students, 4,448 students who lives in urban and rural community were participated as subjects and examined by using New York State Posture Rating Test Method with taking photographs. The results were subdivied into postures of body parts, total posture score, leg types, and lateral deviation and analysed as follows. 1. Postures of body parts 1) Head Tilt For elementary and middle school students, the cases of tilted head were shown more frequently in urban than rural and the ratio of the case of the tilted head was increased as grade was higher. On the other hand, high school studends had the opposite tendency. 2) Uneven Shoulder Height For elementary school childs, higher grades had better condition than lower grades, however, for high school students, those in urban had more cases of uneven shoulder than those in rural and girls showed more deviations than boys. 3) Scoliosis Rural childs had more cases of scoliosis than urban childs, but there were no differences of middle and high school students. 4) Uneven Hip Height Urban and rural childs showed some cases of uneven hip which belonged to normal ranges. Middle and high school studedns werw nearly perfect in the hip height, therefore the condition seems to change as they grow older. 5) Pronated Ankles For this part, those in rural showed better conditions than those in ruban in all age groups and, especially high school third grade students were more satisfactory in rural than urban(84% vs 50%) 6) Forward Head Elementary and middle school students appeared to be satisfactory regardless of age, sex and district, however 32% of high school girl students had forward head. 7) Round Shoulders Many students had round shoulders and some of them revealed severe conditions, There were large differences between urban and rural students. 8) Trunk Hyperextension Generally, girls showed better conditions than boys in trunk posture and, for high school boy students, conditions were differed according to their grades. 9) Sagging Abdomen More cases of sagging abdomen were revealed in ruban that rural for elementary girl students(30% vs 14%). For middle and high school students, there were differences between sex, boys showing more cases than girls in middle school and girls in high school. 10) Lordosis There were differences between urban and rural for elementary childs and high school boy students, however no differences were detected in other groups. Mean degrees of lordosis had a tendency of increasing as the age grew. 2. Total Posture Score For elementary childs, both boys and girls showed differences between urban and rural(75.95 vs 70.73, 75.16 vs 82.42), and, in rural girls seems to be more satisfactory than boys in comparison between boys and girls(p<. 001). In middle school group, rural students appeared to be significantly(p<.05) better than urban students for both sex(83.88 vs 81.93, 75.93 vs 75.02) and the result was same for the high school group(86.52 vs 84.03, 80.07 vs 78.10) 3. Leg types For elementary childs, girls revealed more cases of bowlegs and knock-knee than boys(6% vs 8.2%, 20.5% vs 30.3%). In high school group, the girls in rural showed more cases of bowlegs than those in urban(29.7% vs 13.0%) and, the knokc-knee, the result was opposite(19.3% vs 28.4%). 4. Lateral deviation 1) Head Tilt In elementary group, 11% of boys and 6.3% of girls had lateral deviation and, for high school students, 3.6% of boys and 5.4% of girls showed the deviations revealing girls had more cases of deviation than boys. 2) Uneven Shoulder Height 1.8% of elementary boys and 0.5% of girls had uneven shoulder and totally 1.5% of high school students showed uneven shoulder height. 3) Scoliosis 15.5% and 17.4% of elementary boys and 21.6% and 20.7% of girls deviated to right and left respectively. Urban students showed general trends to leftward deviation while rural students showed rightward deviation. 4) Uneven Hip Height In this part of posture, they showed good conditions in all age, sex, and district.

大邱地域住民의 生活體育 實態分析 : 早起運動參與度를 中心으로 Focusing on participation degree of populations exercising in the morning

蔡鴻遠,金柄斗,李敏炯,金基學,朴宇奎 慶北大學校 體育科學硏究所 1991 체육과학연구지 Vol.7 No.-

The purpose of this study is to get the source materials to activate mass sports of regional populations. At first, it was by sex, age, and occupations examined and analysed populations that would participate in physical activities from 5 to 8 Am at 28 pate-up mountains and 477 workplaces, schools, public facilities, and commercial facilities sontrolled by 7 district offices in Daegu. The mothod of investigation made a preliminary inquiry in advance and set in place 70 investigators in entrance of path-up mountains and sports facilities. Especially, the occupational classification was adopted from socilolgical job calssification model and every result value of analysis was dealed and compared with percentage by means of Daewoo Corona 286 PC. Accordiangly, the concrete conclusions are summarized as follows : 1) The total number of persons participating in mass sports in the morning is 18,045(men 10,850 : 59%, women 7,465 : 41%), and it is about 1% level by the rate of population and low participation rate in comparison with advanced nations. ① It is showed that the participation value in proportion to sex is 17.4% more in men's case taking 10,587 persons(58.7%) than 7,458 persons(41.3%) in women's case. ② Taking the dimensions of participation degree in proportion to age, it is taken the most value in fifties age with 5,092 persons (28%), showing in sixties, forties, thirties, twenties age in sequence. ③ Taking the dimensions of participation degree in proportion to occupation, it is taken the most value in housewife with 5,569 persons (31%), showing the unemployed, independent enterprise, technical expert, clerical work, deministrative position, student, technical work, manual labor, agriculture and forestry, and fishery in sequence. 2) Judging from the participation degree in proportion to district office, it is taken the most value in Mam-gu with 3,821 persons(21.2%) and Dalseo-gu with 3,776 persons(20.9%) and the least in Joong-gu with 1,612 persons(8.9) and Seo-gu with 1,589 persons(8.8%). It is assumed that low participation value in Joong-gu and Seo-gu should result from deficient facilities and close space of urban.

운동선수 생체리듬에 대한 피로도 연구 : K대학교 농구부의 신체리듬을 중심으로

고기채,설민신 경희대학교 체육과학연구소 1991 體育學論文集 Vol.19 No.-

This study was to find out how frequently athletes get tired. In order to find out this research, 8 basketball players at K university were studied by urine examinations, 9. 13 - 10. 5 was the results. The following are the results. 1)The basketball players at K university showed to have higher rythem in sensitivity and intelligence rather then physically. 2)There was no effect on those who had taken these examination, due to the fact that physical rythem contain to hard working othletes. 3)When physical Rhythem was low exhaustion was high. 4)When physical Rhythem was at a low stage going to a higher stage, exhaustion seemed to be high, which was a critical condition.

社會體育振興을 위한 國民意識 再考方案

金柄斗,蔡鴻遠,安禹洪,李敏炯,申榮吉,金基學,鄭相澤,林銖遠 慶北大學校 體育科學硏究所 1987 체육과학연구지 Vol.3 No.-

The purpose of this paper is to investigate and analyze the nation's consciousness about the social physical education by regional groups(big cityes, middle cityes, farm village, fishing villge). And the researchers are to find a way to populize this movement. These subjects for this investigation were chosen at random among the citizens in four region. 4,450 sheets of questionnaire were given to the citizen. And 3,587(81%) sheets of them were received from male(2,582) and female(975) citizens. The results of this investigation are as follows: 1. The nation's consciousness has not been still modernized and the nation tend to depend on their doctors rather than on the new active leisure sports, which is a passive and conventional way, to keep their health. 2. Most people have spent their leisures on nonactive hobby such as reading, listening to music, and watching TV rather than sports. 3. Most residents pointed out lack of facilities, and needed professional directors and various programs they could participate. 4. The opening of citizen athletic field and the gymnasiums to citizens was needed to recruit the lack of facility, and the participation to commercial sport ws differed by economical status and leisure time, however, they usually participated such activities as table-tennis, swimning and tennis. 5. To activate social physical education, first of all, an expansion of the facilities such as athletic fields and gymnasium is needed under the active support of government. 6. The facilities for young men and the handicapped is insufficient, and to prevent juvenile delinquency and guide them into the right way, we should lead them out to participate sports activity. And the facility for the handicapped is needed too.

One-Chip uP에 의한 CO₂가스메탈 아크용접기의 디지털 제어기 설계에 관한 연구

최규하,채영민,송성학,우동학,한광수,안기은 건국대학교 1997 學術誌 Vol.41 No.2

With the development of semiconductor devices, adaptation of microcontroller prevails in industrial area. But in arc welding industry, there has not been much progress in adoption microcontroller technology. Therefore, this paper shows the application of digital control technology to welding machine. This paper presents the design of microcontroller that is appropriate for three phase CO2 gas metal arc welding machine. By using microcontroller in CO2 gas metal arc welding machine, the overact cost can be reduced compared to analog type one. Also TMS370C850 microprocessor is used as overall microcontroller for the arc welding machine.

Racket 運動時의 反應時間과 運動速度 改善을 爲한 Simulator 「SQT」에 關한 硏究

허복,蔡鴻遠,李來華,李敏炯,金基學,鄭相澤,朴宇奎 慶北大學校 體育科學硏究所 1986 체육과학연구지 Vol.2 No.-

The main purpose of this study was to improve greatly the most important reaction time(RT) and speed of movement (SM) at racket exercise by making program for simulator super quality training (S.Q.T) and applying it. The subjects employed were 25 male athletes composed of soccer players 8, volleyball players 7, shooting players 2, soft-tennis players 2, gymnastics player 1, and rugby football player 1 at the Kyungpook National University. We devided each sport player half and half by means of their pre-testing reaction time, and the subjects were devieded into experimental and control group. Experimental group was drilled by using light stimulus simulator training method and control group was drilled by using sound stimulus simulator training method. The training was practiced 20∼30 minutes a day regularly and 5 times a week for 5 weeks. Two groups practiced concentrically experimental learning by using light and sound simulator equipment by S.Q.T. program under equal condition. The propriety on the training effect was investigated by longitudinal analysis of results tested before and after experiment. As the result of the experiment, superiority and inferiority of two groups was evaluated by trying crosssectional analysis. The results obtained were summarized as follows: 1. Reaction time Experimental group; The performance of this group was greatly improved after experiment. Control group; The performance of this group was greatly improved after experiment. Comparison of two groups; Leftward simple completion time showed a significant difference (p<.01), but the other elements did not showed it. As a whole, experimental group was superior to control group, but statistics showed little difference between the two groups. 2. Speed of movement Experimental group; The performance of all elements were improved after experiment(over p<.05). Control group; The performance of this group was improved at only 4 of 9 elements after experiment Comparison of two groups; The performance of service and dash showed a significant difference (p<.01) and the others did not showed it. But as a whole, experimental group was superior to control group in their performance. 3. Viewing Variance and correlation coefficient at the change of RT and SM, there were differences in the variance. This means that the standard deviation is great; i.e. the individual difference is great. The lower correlation coefficient means that correlationship is low in the performance before and after experiment: i.e. it means that individual difference was decreased because the gap of two groups, correlation coefficient became less. Especially, statistics showed that the record of the lower recorded players could be shortened to a maximum.

X-대역 SiGe HBT MMIC 차동형 전압 제어 발진기 개발

김보준,채규성,박민기,김창우 경희-다반 ASIC 설계교육센터 2005 경희-다반 ASIC센터 논문집 Vol.6 No.-

ISO 18000-6B, EPC Class-1 Gen-1, Gen-2 리더 표준에 적용되는 UHF 대역 RFID 리더용 RF 송신기를 하이브리드형 DHC로 설계 및 제작하였다. 송신기의 ASK 변조회로는 하나의 GaAs SPST스위치와 LPF로 구성하였으며, PR-ASK 변조 회로는 하나의 balua 두 개의 GaAs 통PST와 하나의 GaAs SPDT 스위치를 이용하여 link주파수 1-MHz 이상되는 변조신호에서 시간 지연이 없도록 설계하였다. LDMOS를 이용한 전력증폭기는 선형성을 위하여 8-dB back-off 상태로 동작시켜 출력전력 30-dBm을 얻었다.

축구선수들의 코치 리더쉽 선호도 분석

이용인,민춘기,김재운 충남대학교 체육과학연구소 2000 體育科學硏究誌 Vol.18 No.1

The purpose of this study was to analyze the preference of leader behavior styles according to the trait of soccer players. The trait of soccer players was characterized by age, career of winning a prize, birth order. The classified five behavior styles were training and instruction behavior, democratic behavior, autocratic behavior, social support behavior and positiv feedback behavior in the multidimensional model introduced by Chelladurai and Saleh(1980). Total of 286 soccer players were answered to the questionnaire. All subjects were registered players at the federation of soccer and attended national tournament more than once. The findings of this study were as follows: 1) In the preference of leader behavior style among the soccer players, training and instruction behavior was the most perceived behavior style. Democratic behavior, Positive feedback behavior, and social support behavior were preferred to be of second, third and fourth respectively. Autocratic behavior was the least preferred leader behavior style. 2) In the difference of leader behavior style according to the age of soccer players, middle school team preferred more than pro team in the training and instruction behavior, democratic behavior, and positive feedback behavior. 3) No significant difference was found according to the career of winning a prize and birth order of soccer players in the preference of leader behavior styles.