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      저자 : Michela de Martino (검색결과 1 건)
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        Associations Between Presenting Symptoms, Clinicopathological Parameters, and Prognosis in a Contemporary Series of Patients With Renal Cell Carcinoma

        Sebastian L. Hofbauer,Michela de Martino,Christoph Seemann,Nura Zamani,Ilaria Lucca,Andrea Haitel,Shahrokh F. Shariat,Tobias Klatte 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.8

        Purpose: To evaluate the impact of presenting symptoms on survival in a contemporaryseries of patients with renal cell carcinoma (RCC). Materials and Methods: We prospectively recorded data on the presenting symptoms,pathology, and RCC-specific survival of 633 consecutive RCC patients who underwentsurgery between 2003 and 2012. Results: Four hundred thirty-three RCCs (68%) were incidental, 111 (18%) were associatedwith local symptoms, and 89 (14%) were associated with systemic symptoms. Among those with incidental RCC, 317 patients (73%) were completely asymptomaticand 116 patients (27%) presented with symptoms not related to the tumor. During amedian follow-up interval of 40 months (interquartile range: 39 to 69 months), 77 patientsdied from RCC. In univariate analyses, symptom classification was significantlyassociated with RCC-specific survival (p<0.001). Patients with incidental RCC andunrelated symptoms tended to have worse prognosis than did patients who were completelyasymptomatic, although this difference was not statistically significant(p=0.057). The symptom classification was associated with advanced TNM stages (p<0.001) and grade (p<0.001). Conclusions: This study confirms that presenting symptoms are associated with tumorcharacteristics and survival. The majority of RCCs are diagnosed incidentally in patientswithout any symptoms or with symptoms not related to RCC. Patients in the lattergroup tend to have a worse prognosis than do patients who are completelyasymptomatic. With the increasing number of incidentally diagnosed RCCs, substratificationof patients with incidental tumors may be prognostically relevant.

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