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Political entrepreneurship and the Ko-P phenomenon in Taiwan’s democratization
Ho-don Yan,Michael S. H. Heng 서울대학교행정대학원 2016 Asian Journal of Political Science Vol.24 No.3
Taiwan’s economic modernization and political democratization after World War II have been praised as good examples for emerging countries. As of 2014, Taiwan has successfully gone through four direct presidential elections and two rounds of peaceful transfer of power. However, continuing sectarian quarrels between the ruling Kuomintang and the opposition Democratic Progressive Party cast doubt on the suitability of democracy for a Confucian society. This pessimism is challenged by the emergence of a new political star. A political novice, Ko Wen-je (aka Ko-P), won a landslide victory in the 2014 Taipei mayoral election, which is seen as a phenomenon. It has significant political implications and has so far inspired changes in the political landscape. The adoption of entrepreneurial strategies, such as identifying problems, leading by example, and team creation, are unprecedented in Taiwan’s political campaign. The Ko-P phenomenon demonstrates a self-correcting mechanism in Taiwan’s political system and bodes well for the future of new democracies, particularly for the Greater China Region.
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Min-Hsiang Chuang,Yu-Shuo Tang,Jui-Yi Chen,Heng-Chih Pan,Hung-Wei Liao,Wen-Kai Chu,Chung-Yi Cheng,Vin-Cent Wu,Michael Heung 대한당뇨병학회 2024 Diabetes and Metabolism Journal Vol.48 No.2
Background: The initiation of sodium-glucose cotransporter-2 inhibitors (SGLT2i) typically leads to a reversible initial dip in estimated glomerular filtration rate (eGFR). The implications of this phenomenon on clinical outcomes are not well-defined.Methods: We searched MEDLINE, Embase, and Cochrane Library from inception to March 23, 2023 to identify randomized controlled trials and cohort studies comparing kidney and cardiovascular outcomes in patients with and without initial eGFR dip after initiating SGLT2i. Pooled estimates were calculated using random-effect meta-analysis.Results: We included seven studies in our analysis, which revealed that an initial eGFR dip following the initiation of SGLT2i was associated with less annual eGFR decline (mean difference, 0.64; 95% confidence interval [CI], 0.437 to 0.843) regardless of baseline eGFR. The risk of major adverse kidney events was similar between the non-dipping and dipping groups but reduced in patients with a ≤10% eGFR dip (hazard ratio [HR], 0.915; 95% CI, 0.865 to 0.967). No significant differences were observed in the composite of hospitalized heart failure and cardiovascular death (HR, 0.824; 95% CI, 0.633 to 1.074), hospitalized heart failure (HR, 1.059; 95% CI, 0.574 to 1.952), or all-cause mortality (HR, 0.83; 95% CI, 0.589 to 1.170). The risk of serious adverse events (AEs), discontinuation of SGLT2i due to AEs, kidney-related AEs, and volume depletion were similar between the two groups. Patients with >10% eGFR dip had increased risk of hyperkalemia compared to the non-dipping group.Conclusion: Initial eGFR dip after initiating SGLT2i might be associated with less annual eGFR decline. There were no significant disparities in the risks of adverse cardiovascular outcomes between the dipping and non-dipping groups.
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