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김무강,Mi-SunPark,Mi-YoungLee,Keun-JwaLee,Young-GilJeong,Chul-HoLee,Kwon-SooHa,Man-HeeRhee,Kang-YiLee,Kyoug-YoulLee,Chi-WonSong,권효정 대한수의학회 2002 Journal of Veterinary Science Vol.3 No.3
The distribution of the nerve growth factor (NGF),the glial fibrillary acidic protein (GFAP) and theciliary neurotrohic factor (CNTF) was performed incoronal sections of the mesencephalon, rhombencephalonand spinal cord in the developing Mongolian gerbils.Generaly, NGF specificaly recognizes neurons withthe NGF receptor, whereas GFAP does the glia, andwas examined separately in gerbils between embryonicdays 15 (E15) and postnatal weks 3 (PNW 3). TheNGF-IR was first observed in the spinal cord at E21,which might be related to the maturation. The GFAPreactivity was peaked at he postnatal days 2 (PND2),while the highest CNTF-reaction was expresed atPNW 2. The GFAP stains were observed in theaqueduct and the spinal cord, which appeared toproject lateraly at E19. The CNTF was observed onlyafter the birth and found in both the neurons andcerebelum and the spinal cord from PND1 to PNW3.These results uggest hat NGF, GFAP and CNTF areimportant for the development of the neurons and theneuroglia in the central nervous system at he lateprenatal and postnatal stages.
DNA Topoisomerases I and Il Inhibitory Activity of Constituents Isolated from Juglans mandshurica
GaoLi,Sun-YoungLee,Kyeung-SeonLee,Sung-WonLee,Sang-HyunKim,Seung-HoLee,Chong-SoonLee,Mi-HeeWoo,Jong-KeunSon 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.6
Nine diarylheptanoids (1-9), one triterpene (10), one sesquiterpenoid (11), one naphthoquinone (12), four tetralones (13-16), one naphthalene carboxylic acid glucoside (17) and six naphthalenyl glycosides (18 -23) were isolated from the roots of Juglans mandshurica Maximowicz (Juglandaceae), and their structures determined from the chemical and spectral data. Here, we report the inhibitory effects, on the DNA topoisomerases I and II activities, of all these compounds. Compounds 10 and 23 showed more potent inhibitory effects, on the DNA topoisomerases I and II (94.0 and 86.0% inhibitions at the concentration of 5 mg/mL, respectively), than the positive control compounds, camptothecin and etoposide.