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Goo, Moon-Jung,Ki, Mi-Ran,Lee, Hye-Rim,Hong, Il-Hwa,Park, Jin-Kyu,Yang, Hai-Jie,Yuan, Dong-Wei,Hwang, Ok-Kyung,Do, Sun-Hee,Yoo, Sung-Eun,Jeong, Kyu-Shik Lippincott Williams Wilkins, Inc. 2008 European journal of gastroenterology & hepatology Vol.20 No.10
We report a case of primary biliary cirrhosis (PBC) that occurred in a 24-month-old male C57BL/6 mouse infected with Helicobacter pylori (H. pylori). Microscopically, the portal tract in the liver showed nonsuppurative destructive cholangitis with variable cytologic distortion of the epithelial cells and peribiliary lymphoplasmacytic infiltration. Immunohistochemistry using α-smooth muscle actin demonstrated fibrous bands associating with the wall of vasculature. The level of serum antivacuolating toxin IgG in this mouse showed the highest value (optical density=2.1470) of the H. pylori-infected group (n=13) (optical density=1.7168±0.1759, mean±SD). Spontaneously developed PBC-like lesions in C57BL/6 mice have been reported by several authors. However, this case strikingly resembles human PBC with its characterized histological features. Therefore, we propose that the increase in vacuolating toxin caused by H. pylori infection may be related to the development of PBC by molecular mimicry.
Multiple urogenital abnormalities in a Persian cat
Goo, Moon-Jung,Williams, Bruce H.,Hong, Il-Hwa,Park, Jin-Kyu,Yang, Hai-Jie,Yuan, Dong-Wei,Lee, Hye-Rim,Hong, Kyung-Sook,Ki, Mi-Ran,Jeong, Kyu-Shik Elsevier 2009 JOURNAL OF FELINE MEDICINE AND SURGERY Vol.11 No.2
<P>A 1.5-year-old female Persian cat was presented for inappetence and azotemia. Ultrasonography and urography revealed multiple abnormalities involving the genitourinary tract, including agenesis of the right kidney and ureter. Gross examination of the abnormal uterus revealed segmental aplasia of right caudal uterine horn causing cranial distension with fluid, a normal left uterine horn, and both normal ovaries. Microscopically, endometrial glands of the right uterine horn were markedly decreased in number. The right uterine horn was hemorrhagic suggesting estrus. This is the first report of this combination of urinary and uterus abnormalities in the veterinary literature.</P>
Time-dependent Changes of Cadmium and Metallothionein after Short-term Exposure to Cadmium in Rats
Mi Ran Cho,Hwan Goo Kang,Sang-Hee Jeong,Myung Haing Cho 한국독성학회 2010 Toxicological Research Vol.26 No.2
The time-dependent changes in cadmium (Cd) concentration were studied in Female Sprague-Dawley (SD) rats during and after Cd exposure via drinking water (10 and 50 ppm) for 30 days. The cadmium concentration in muscle, liver, kidney, blood plasma, and urine, and the metallothionein concentration in blood plasma were determined every 10 days during exposure and every 7 days after exposure for 3 weeks. The muscle Cd concentration did not change during, and neither after, exposure. The liver Cd concentration increased from 1.4 to 3.3 (at 10 ppm) and from 6.1 to 10.1 folds (at 50 ppm) during exposure and remained higher than those of controls in both groups even during post-exposure period. The kidney Cd concentrations were 2.3 to 5.1 (at 10 ppm) and 4.9-14.0 folds (at 50 ppm) higher than those of controls during exposure and also remained elevated during the post-exposure period. Plasma Cd concentrations were not significantly different from those of controls in both groups. Urine Cd concentrations were more than 2 folds (at 10 ppm) and 6.5 to 12.6 folds (at 50 ppm) higher than those of controls but rapidly decreased over the 7 days of withdrawal. Blood plasma metallothionein concentrations were more than 2.4 folds (at 10 ppm) and 3.1 to 7.4 folds (at 50 ppm), and they remained elevated till 7 days (10 ppm) and 14 days (at 50 ppm) after exposure. Our data support that Cd in urine could be a useful biomarker during Cd exposure period and metallothionein in blood plasma could be as a supportive biological marker for during and post Cd exposure.
Helicobacter pylori promotes hepatic fibrosis in the animal model
Goo, Moon-Jung,Ki, Mi-Ran,Lee, Hye-Rim,Yang, Hai-Jie,Yuan, Dong-Wei,Hong, Il-Hwa,Park, Jin-Kyu,Hong, Kyung-Sook,Han, Jung-Youn,Hwang, Ok-Kyung,Kim, Dong-Hwan,Do, Sun-Hee,Cohn, Ronald D,Jeong, Kyu-Shik Springer Science and Business Media LLC 2009 Laboratory investigation Vol.89 No.11
<P>Helicobacter pylori infection has been reported to be very common in patients with chronic liver diseases, including cirrhosis. To elucidate the pathological effect of H. pylori infection on the progression of hepatic fibrosis, C57BL/6 mice and Sprague-Dawley rats were orally inoculated with H. pylori, and hepatic fibrosis was induced with carbon tetrachloride (CCl(4)) administration. We observed the histopathological changes and the presence of H. pylori genes by PCR in the liver. Significant increase in the fibrotic score as well as in serum alanine aminotransferase and aspartate aminotransferase levels was shown in the CCl(4)+H. pylori group compared with that in the CCl(4)-treated group. Compared with the CCl(4)-treated group, alpha-smooth muscle actin and transforming growth factor-beta1 were enhanced; however, senescence marker protein-30, a multifunctional protein protecting hepatocytes against oxidative stress and apoptosis, was suppressed in the CCl(4)+H. pylori group. The 16S rRNA (400 bp) was demonstrated by PCR for H. pylori genes from genomic DNA extracted from the liver, and H. pylori-infected mice showed 93.8% (15 of 16) seropositivity by contrast with seronegativity in all H. pylori-noninfected mice. In addition, immunohistochemical study against H. pylori showed positive antigen fragments in the liver of the infected groups. Consequently, our data suggest that H. pylori infection could be an important contributing infectious factor to the development of liver cirrhosis.</P>