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- 저자 : Mert Kilic (검색결과 2 건)
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Intolerance to Sunitinib Treatment in Hemodialysis Patients With Metastatic Renal Cell Carcinoma
Ibrahim Yildiz,Fatma Sen,Leyla Kilic,Rumeysa Ciftci,Mert Basaran 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.1
Sunitinib is a multiple tyrosine kinase receptor inhibitor that is approved for the treatmentof metastatic renal cell carcinoma (RCC). However, neither an appropriate dosenor dosing schedule of sunitinib has yet been established for patients with metastaticRCC who are on hemodialysis. Here, we report on two hemodialysis patients who receivedsunitinib to treat metastatic RCC. Sunitinib was planned to be administeredat a dosage of 25 mg/d for 4 of every 6 weeks. Although sunitinib toxicity was manageablein one patient, disease progression occurred after 4 months of treatment. In the secondpatient, acute pulmonary edema, caused by uncontrolled hypertension, developed onthe 15th day of sunitinib therapy and the drug had to be discontinued. Sunitinib is thusnot well tolerated in a hemodialysis setting. Close monitoring of toxicity and dose manipulationmay be required if such therapy is attempted.
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Is Activating Transcription Factor 3 Up-Regulated in Patients with Hypospadias?
Cenk Gurbuz,Selamettin Demir,Ebru Zemheri,Lutfi Canat,Mert Kilic,Turhan Caskurlu 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.8
Purpose: Even though hypospadias is one of the most common congenital anomalies, the cause of hypospadias is largely unknown. With regard to molecular biology and microarray technology, it appears that hypospadias is potentially related to disrupted gene expression. Genomic analysis of hypospadiac tissue indicated a potential role for activating transcription factor 3 (ATF3) in the development of this anomaly. This study prospectively examined the expression of ATF3 in tissues from 20 children with hypospadias compared with 26 normal penile skin tissue samples from elective circumcision. Materials and Methods: Prepucial tissue was obtained from children who underwent repair of hypospadias for comparison with tissue samples from children who underwent elective circumcision. Skin specimens were evaluated for the expression of ATF3 protein by immunohistochemical staining. Results: Immunohistochemical staining for ATF3 in samples from children who underwent repair of hypospadias was significantly greater than in samples from children who underwent elective circumcision (80% vs. 11%, respectively; p<0.05). Conclusions: Our results indicate that ATF3 is up-regulated in the penile skin tissue of boys with hypospadias, which suggests a role for this transcription factor in the development of this abnormality.
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