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Effects of Surface Energy on the Nonlinear Behaviors of Laminated Nanobeams
Menghua Xu,Baolin Wang,Aibing Yu 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.4 No.1
Using an improved multilayer-beams model, the surface effect caused by surface stress and surface elasticity on mechanical properties of laminated nanobeams in bending, bucking and vibration is incorporated into the nonlinear beam theory. Analytical solutions are obtained to study the influence of surface and interface effects for simply supported boundary conditions. Unlike the deduction of previous beam theory, the theoretical derivation in present work includes the effect of both surface and interface. Numerical cases of double layer and multilayer Nickel-silver laminated beams indicate that the interface effect observably change the elastic behaviour of laminated beams on the nanometer scale, especially for multilayer cases.
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Cuifang Chang,Cunshuan Xu,Weiming Zhao,Jing Yang,Menghua Li,Yun Zhou 한국통합생물학회 2014 Animal cells and systems Vol.18 No.6
To understand the mechanism of hepatocyte differentiation during rat liver regeneration (LR) at the genetranscription level, Rat Genome 230 2.0 Array was used to determine the gene expression changes ofhepatocytes. Then the genes associated with cell differentiation and their signaling pathways were searched byNCBI, QIAGEN and KEGG webs, and their signaling activities were calculated by spectral function Ep(t)based on the expression profiles. The key genes associated with the signaling pathways and cell differentiationwere analyzed and verified by the same kind extraction method. The mechanism of hepatocyte differentiationduring rat LR was analyzed by Ingenuity Pathway Analysis 9.0 (IPA). The results showed that 42 signalingpathways regulated cell differentiation and the Ep(t) values of IL-9 signaling pathway and its JAK/STAT andPI3K/AKT branches, PEDF signaling pathway and its NF-κB and Ras/ERK branches were significantlyincreased in the progression phase (6–72 h after partial hepatectomy [PH]) of rat LR, and the Ep(t) values ofhepatocyte differentiation were also significantly increased. ERK/MAPK signaling pathway was significantlyincreased in the priming (0.5–6 h after PH) and progression phase, and hepatocyte differentiation were alsosignificantly increased. In conclusion, among the 42 signaling pathways that regulated cell differentiation, thesignaling activity of IL-9 signaling pathway and its JAK/STAT and PI3K/AKT branches, PEDF signalingactivity and its NF-κB and Ras/ERK branches, and ERK/MAPK signaling activity were significantly increasedand promoted hepatocyte differentiation in rat LR. Meanwhile, the expression of MYC involved in mentionedsignaling pathways and expression of AGT, BCL2, IL10, CCND1, PLAT, and NF1 related to celldifferentiation were increased significantly.
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