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Saeed Farzamfar,Majid Salehi,Arian Ehterami,Mahdi Naseri-Nosar,Ahmad Vaez,Amir-Hassan Zarnani,Hamed Sahrapeyma,Mohammad Reza Shokri,Mehdi Aleahmad 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.4
This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation viadecellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM wasseeded with MenSCs at the density of 3 9 104 cells/cm2 and implanted onto a rat’s 1.50 9 1.50 cm2 full-thicknessexcisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSCseededDAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicatedthat the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.