니트제품 생산업체 디자인·기획 및 생산 현황에 관한 연구

이윤미,박재옥,이연희 服飾文化學會 2004 服飾文化硏究 Vol.12 No.2

The purpose of this study is to investigate design process and production in the Korean knitwear industry and to examine the possibility fur our knitwear industry to develop into the developed countries' model. This purpose was empirically pursued through questionnaires, of which respondents were 110 designers, merchandiser(MD), and top managers of knitwear companies and jobbers in Seoul. The questionnaires were analyzed on the basis of such statistical tools as χ^(2)-test, t-test, and one-way ANOVA. Findings of this study were as follows. Designers of knitwear companies evaluated that their design is more creative than that of designers of jobbers. But designers of knitwear companies and jobbers all responded that they obtained their design ideas from samples produced by leading foreign knitwear companies. The dominant form by which knitwear companies use jobbers was that knitwear companies do a major part of designing and order jobbers to elaborate it and produce knitwear samples. The most important reason of hiring jobbers was to obtain specialized technical skills and knowledge.

말기환자 관리에 대한 의사들의 태도

최윤선,김장욱,신승욱,이영미,이태호,홍명호 가톨릭대학교 가톨릭대학교 간호대학 호스피스 교육연구소 1998 호스피스논집 Vol.3 No.-

Background : Nowadays, it is possible to prolong the life. And to improve the quality of life of the dying patients, they need to receive not only the physical, pscychological, social and spiritual care but also comprehensive and continuous care. Also, doctors have to consider many ethical issues especially in the dying patients. The purpose of this study is to analyze the doctors' attitude of those ethical issues and emphasize the importance of hospice. Methods : During September 1996, doctors who worked for a university hospital participated in this study by responding to the pre-made questionnaire. It dealt with the most suffering pain, the preferred death place, the use of life maintaining equipments, the application of cardiopulmonary resuscitation(CPR) to terminal patients and the doctors' experience and attitude euthanasia. Results : ① The most suffering symptom in dying patients was pain(60.0%). ② The death place was recommended by doctors was home(58.8%) and hospital (15.4%) in order. ③ 56.9% of doctors answered 'the life maintaining equipments isn't needed', 29.2% of doctors answered' according to the case', and 'needed' was 12.3%. ④ The application of CPR to the terminal patients, without the DNR chart, the only 15.4% of doctors answered "Do not CPR." But with the DNR chart, the percents of 'Do not CPR' was increased to 69.2%. The resident group did more CPR than specialist group(p<0.01). ⑤ The 50.8% of doctors agreed with the passive euthanasia. Conclusions : Many doctors follow the family member's opinion in the ethical issues of the dying patients. Euthanasia is forbidden by the law in Korea, but many doctors agree with the passive euthanasia. Hospice can solve the debating ethical issues including the euthanasia.

암과 생활사건스트레스 및 가족기능의 연관성

최윤선,이영미,홍명호,천병철,Choi, Youn-Seon,Lee, Young-Mee,Hong, Myung-Ho,Chun, Byung-Chul 한국호스피스완화의료학회 1999 한국호스피스.완화의료학회지 Vol.2 No.2

목적 : 정신사회학적 문제는 건강에 직접 혹은 간접으로 영향을 미친다. 이에 가족기능 및 스트레스와 암과의 연관성을 조차하여 포괄적인 진료에 도움이 되고자 본 연구를 시행하였다. 방법 : 1995년 9월부터 1997년 9월말까지 모 대학 부속병원 2곳에 입원한 암환자 150명과 건강검진센터에서 조사에 응한 250명 중 선별검사를 통해 대조군 105명을 대상으로 표준화된 설문지를 이용하여 가족기능과 스트레스량을 측정하였다. 통계처리는 주로 SAS(version 6.12)를 이용하였고, 가족기능과 암과의 연관성을 파악하기 위해 EGRET(version 0.25.6)을 이용한 다중 로지스틱 회귀분석을 시행하였다. 결과 : 1) 단변량분석에서 환자군은 대조군과 연령, 사회경제적 수준에서 유의한 차이를 보여서, 암환자에서 고령이 많았고, 사회경제수준이 낮았으며 교육수준과 결혼상태는 경계역의 유의성을 보였다. 2) 가족기능을 조화형, 중간형, 극단형으로 나누었을 때 양군간의 차이는 유의하지 않았으나, 선형경향성 분석에서는 암환자가 극단형 가족에서 적었다(P<0.05). 3) 환자군과 대조군 사이에 생활사건스트레스 종류 및 스트레스량과는 통계적으로 유의한 차이가 없었다. 4) 다중 로지스틱 회귀분석시도 가족기능과 생활사건스트레스의 양과 종류는 유의하지 않았다. 결론 : 가족 기능 및 생활사건스트레스량 등 정신사회적 변수와 암과의 관련성을 통계적으로 증명할 수 없었는데 정신사회적 변수와 더불어 음식과 환경적 위험요인 등이 암발생의 위험과 사망률을 증가시킨다는 것을 간접적으로 뒷받침해주는 것으로 정신사회적 요인만으로 암발생 및 만성질환에 관한 가설을 증명하는데에는 보다 많은 연구가 필요하다. 보였다. 결론 : 본 연구의 결과는 호스피스 자원봉사자를 위한 프로그램 개발 시 중요한 기초 자료를 제시하고 있다.연구할 필요가 있음을 제언한다.별로는 가톨릭의 경우 요구도가 가장 높았다. 호스피스 간호 요구도는 호스피스에 대해 들어본 경험, 죽음에 대한 준비, 불치병에 대한 통고 및 호스피스의 필요성 인식에 따라 유의한 차이를 보였다. 즉, 호스피스에 대해 들어본 군, 죽음을 미리 준비해야 된다고 전적으로 긍정한 군, 불치병에 대한 통고를 원하는 군, 그리고 필요시에 호스피스 간호를 받겠다는 군에서 호스피스 간호 요구도가 유의하게 높았다. 결론 : 본 연구의 결과는 호스피스에 대한 인지정도를 높일 수 있는 홍보와 교육이 필요함을 시사하며, 지역사회 주민들의 요구를 충족시켜 삶의 질을 향상시키기 위한 가정 호스피스를 발전시키고 나아가서는 전반적인 호스피스 발전을 위한 유용한 자료가 될 것으로 기대된다.X>${\sim}$1시간 정도 빠르게 적용되고 있는 곳이다. 8) 세계의 많은 나라가 표준시를 태양시보다 30분${\sim}$1시간 또는 그 이상까지도 빠르게 적용하고 있다는 사실, 그리고 세계의 많은 나라에서 서머타임을 시행하고 있다는 사실을 보면 태양시보다 표준시를 어느 정도 빠르게 적용해 생활하는 것은 인간 생체리듬에 악영향을 미치지 않으면서 오히려 시간 이용을 효율화하는 장점이 있는 것으로 판단된다. 9) 현재 우리나라는 경도 $135^{\circ}E$를 기준으로 하는 I-시간을 사용하고 있으면서 I-시간대역의 서쪽경계에 위치하여 태양시보다 표준시가 30분 정도 빠르다. 이는 한국인의 생체리듬에 결코 나쁜 영향을 주지 않으며, 오히려 Purpose : To clarify the relation between psychosocial variables and cancer in Korea. Methods : Case-control study. Participants: 239 subjects in 2 university hospitals in Seoul completed a series of psychometric instruments(the Olson's FACES III and the Lee's 98-items life event scale). Results : In bivariable analysis, there were statistically significant difference in age and economic status(income): marginal significance in education status and marital status between the cases and controls. The family function type and stress score were not significantly different. The result of multivariable logistic regression, analysis showed that the risk of cancer was associated with economic status and marital status, but neither the family function nor the life event stress. Conclusion : In this study, we cannot prove the statistical association between the family function, life event stress and cancer. It is necessary to persevere in our efforts to clarify the relation between stress and disease and to develop the useful tools to measure the Korean family function and life event stress.

The Role of Cyclosporine and Mycophenolate in an Orthotopic Porcine-to-Rat Corneal Xenotransplantation

Lee, Hyeon Il,Kim, Mee Kum,Oh, Joo Youn,Ko, Jung Hwa,Lee, Hyun Ju,Wee, Won Ryang,Lee, Jin Hak The Korean Academy of Medical Sciences 2008 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.23 No.3

<P>We performed this study to investigate the feature of rejection in porcine-to-rat corneal orthotopic transplantation and to evaluate the effect of cyclosporine and mycophenolate on the xeno-rejection. Orthotopic corneal transplantation was done at 91 Sprague-Dawley rats, and they were divided into 10 groups based on the combination of immunosuppressants including dexamethasone, cyclosporine, and mycophenolate mofetil. Graft survival was analyzed and grafted eyes were examined with Hematoxylin & Eosin and CD4 or CD8 staining. Enzyme-linked immunosorbent assays were done for interleukin-2 (IL-2), IL-4, IL-5, IL-10, and interferon (IFN)-γ in cornea, lacrimal gland, and cervical lymph nodes. The longest median survival of the immune suppressant group was 11.00±1.96 days, which showed no statistical differences compared with that of control (8.00±1.52 days). The neutrophils were prominent in the early phase but soon gave way to the monocytes. The number of CD8+ cells was higher than that of CD4+ cells. IL-2 and IFN-γ markedly increased at 10 to13 days in cornea, lacrimal glands, and cervical lymph nodes, which showed a decrease with immunosuppressants except in the cornea. In conclusion, cyclosporine and mycophenolate could not prevent the rejection in porcine to rat orthotopic corneal xenograft associated with infiltraton of CD8+ and innate immune cells.</P>

The Product Market Strategies of Korean Knitwear Companies

Lee, Yoon-Mee,Park, Jae-Ok,Lee, Youn-Hee The Costume Culture Association 2004 Fashion, industry and education Vol.7 No.1

The purpose of this study is to investigate how three factors--designer's capability, product market strategy, and product organization--supposed to determine the design process are related to each other. These factors influence Korean knitwear companies' market performances. For this purpose, we did not only library research on relevant theories such as the transaction cost economics but also empirical research largely based on a questionnaire. The respondents of the questionnaire were 59 designers, merchandisers(MDs), and top managers of knitwear companies located in Seoul. We analyzed the collected questionnaire data by using such statistical tools as χ²-test, t-test, and one-way ANOVA. Findings of this study were as follows. While there was a significant relation between organization form and designer's capability, no significant difference in designer's capability was found between trust enhanced network and unenhanced network. No significant relation was found between organization form and product market strategy, in discordance with Carney's arguments. Also, it appeared that there was no significant relationship between knitwear companies' product market strategies and their designers' capabilities.

Unraveling dynamic metabolomes underlying different maturation stages of berries harvested from Panax ginseng

Lee, Mee Youn,Seo, Han Sol,Singh, Digar,Lee, Sang Jun,Lee, Choong Hwan The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.3

Background: Ginseng berries (GBs) show temporal metabolic variations among different maturation stages, determining their organoleptic and functional properties. Methods: We analyzed metabolic variations concomitant to five different maturation stages of GBs including immature green (IG), mature green (MG), partially red (PR), fully red (FR), and overmature red (OR) using mass spectrometry (MS)-based metabolomic profiling and multivariate analyses. Results: The partial least squares discriminant analysis score plot based on gas chromatography-MS datasets highlighted metabolic disparity between preharvest (IG and MG) and harvest/postharvest (PR, FR, and OR) GB extracts along PLS1 (34.9%) with MG distinctly segregated across PLS2 (18.2%). Forty-three significantly discriminant primary metabolites were identified encompassing five developmental stages (variable importance in projection > 1.0, p < 0.05). Among them, most amino acids, organic acids, 5-C sugars, ethanolamines, purines, and palmitic acid were detected in preharvest GB extracts, whereas 6-C sugars, phenolic acid, and oleamide levels were distinctly higher during later maturation stages. Similarly, the partial least squares discriminant analysis based on liquid chromatography-MS datasets displayed preharvest and harvest/postharvest stages clustered across PLS1 (11.1 %); however, MG and PR were separated from IG, FR, and OR along PLS2 (5.6 %). Overall, 24 secondary metabolites were observed significantly discriminant (variable importance in projection > 1.0, p < 0.05), with most displaying higher relative abundance during preharvest stages excluding ginsenosides Rg1 and Re. Furthermore, we observed strong positive correlations between total flavonoid and phenolic metabolite contents in GB extracts and antioxidant activity. Conclusion: Comprehending the dynamic metabolic variations associated with GB maturation stages rationalize their optimal harvest time per se the related agroeconomic traits.

Liquid Chromatography-Mass Spectrometry-Based Chemotaxonomic Classification of Aspergillus spp. and Evaluation of the Biological Activity of Its Unique Metabolite, Neosartorin

( Mee Youn Lee ),( Hye Min Park ),( Gun Hee Son ),( Choong Hwan Lee ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.7

This work aimed to classify Aspergillus (8 species, 28 strains) by using a secondary metabolite profile-based chemotaxonomic classification technique. Secondary metabolites were analyzed by liquid chromatography ion-trap mass spectrometry (LC-IT-MS) and multivariate statistical analysis. Most strains were generally well separated from each section. A. lentulus was discriminated from the other seven species (A. fumigatus, A. fennelliae, A. niger, A. kawachii, A. flavus, A. oryzae, and A. sojae) with partial least-squares discriminate analysis (PLS-DA) with five discriminate metabolites, including 4,6-dihydroxymellein, fumigatin, 5,8-dihydroxy-9- octadecenoic acid, cyclopiazonic acid, and neosartorin. Among them, neosartorin was identified as an A. lentulus-specific compound that showed anticancer activity, as well as antibacterial effects on Staphylococcus epidermidis. This study showed that metabolite-based chemotaxonomic classification is an effective tool for the classification of Aspergillus spp. with species-specific activity.

Construing temporal metabolomes for acetous fermentative production of <i>Rubus coreanus</i> vinegar and its <i>in vivo</i> nutraceutical effects

Lee, Mee Youn,Kim, Hyang Yeon,Lee, Da Eun,Singh, Digar,Yeo, Soo Hwan,Baek, Seong Yeol,Park, Yoo Kyoung,Lee, Choong Hwan Elsevier 2017 Journal of Functional Foods Vol.34 No.-

<P><B>Abstract</B></P> <P>The temporal metabolomes associated with <I>Rubus coreanus</I> (RC) vinegar production were delineated using mass spectrometry-based metabolomic analyses with multivariate studies. We observed a clustered pattern of 27 discriminant metabolites: 4 organic acids, 9 sugars and sugar derivatives, 2 alcohol and carboxylic acid, 6 esters, and 6 terpenes. The levels of organic acids and alcohols were steadily decreased throughout fermentation, whereas those of sugars and sugar derivatives, carboxylic acids, esters, and terpenes peaked at 6days. Further, the <I>in vivo</I> nutraceutical potentials of RC vinegar were examined with its metabolomic implications for bone health in growing rat model. Intriguingly, the plasmatic metabolomes among treated rat groups were observed with lower levels of non-essential amino acids and lysophosphatidylcholines (LysoPCs) coupled with higher levels of fatty acids and bile acids. The plasmatic metabolomes complemented with bone morphometric and clinical parameters suggest the bone health ameliorating effects of RC vinegar.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We construed temporal metabolomes for <I>Rubus coreanus</I> (RC) vinegar fermentation. </LI> <LI> Overall 27 discriminant metabolites were identified towards fermentative stages. </LI> <LI> Dietary RC vinegar supplementation promotes bone health in growing rats. </LI> <LI> Serum metabolomes and clinical parameters of bone health were positively affected. </LI> </UL> </P>

Metabolomics-Based Chemotaxonomic Classification of Streptomyces spp. and Its Correlation with Antibacterial Activity

( Mee Youn Lee ),( Hyang Yeon Kim ),( Sa Rah Lee ),( Jeong Gu Kim ),( Joo Won Suh ),( Choong Hwan Lee ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.8

Secondary metabolite-based chemotaxonomic classification of Streptomyces (8 species, 14 strains) was performed using ultraperformance liquid chromatography-quadrupole-time-offlight- mass spectrometry with multivariate statistical analysis. Most strains were generally well separated by grouping under each species. In particular, S. rimosus was discriminated from t he r emaining s ev en s pecies ( S. coelicolor, S. griseus, S. indigoferus, S. peucetius, S. rubrolavendulae, S. scabiei, and S. virginiae) in partial least squares discriminant analysis, and oxytetracycline and rimocidin were identified as S. rimosus-specific metabolites. S. rimosus also showed high antibacterial activity against Xanthomonas oryzae pv. oryzae, the pathogen responsible for rice bacterial blight. This study demonstrated that metabolite-based chemotaxonomic classification is an effective tool for distinguishing Streptomyces spp. and for determining their species-specific metabolites.

Unraveling dynamic metabolomes underlying different maturation stages of berries harvested from Panax ginseng

Mee Youn Lee,Han Sol Seo,Digar Singh,Sang Jun Lee,이충환 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.3

Background: Ginseng berries (GBs) show temporal metabolic variations among different maturationstages, determining their organoleptic and functional properties. Methods: We analyzed metabolic variations concomitant to five different maturation stages of GBsincluding immature green (IG), mature green (MG), partially red (PR), fully red (FR), and overmature red(OR) using mass spectrometry (MS)ebased metabolomic profiling and multivariate analyses. Results: The partial least squares discriminant analysis score plot based on gas chromatographyeMSdatasets highlighted metabolic disparity between preharvest (IG and MG) and harvest/postharvest (PR,FR, and OR) GB extracts along PLS1 (34.9%) with MG distinctly segregated across PLS2 (18.2%). Fortythreesignificantly discriminant primary metabolites were identified encompassing five developmentalstages (variable importance in projection > 1.0, p < 0.05). Among them, most amino acids, organic acids,5-C sugars, ethanolamines, purines, and palmitic acid were detected in preharvest GB extracts, whereas6-C sugars, phenolic acid, and oleamide levels were distinctly higher during later maturation stages. Similarly, the partial least squares discriminant analysis based on liquid chromatographyeMS datasetsdisplayed preharvest and harvest/postharvest stages clustered across PLS1 (11.1 %); however, MG and PRwere separated from IG, FR, and OR along PLS2 (5.6 %). Overall, 24 secondary metabolites were observedsignificantly discriminant (variable importance in projection > 1.0, p < 0.05), with most displayinghigher relative abundance during preharvest stages excluding ginsenosides Rg1 and Re. Furthermore, weobserved strong positive correlations between total flavonoid and phenolic metabolite contents in GBextracts and antioxidant activity. Conclusion: Comprehending the dynamic metabolic variations associated with GB maturation stagesrationalize their optimal harvest time per se the related agroeconomic traits.