http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mazrad, Zihnil Adha Islamy,Choi, Cheong A,Kim, Sung Han,Lee, Gibaek,Lee, Sangkug,In, Insik,Lee, Kang-Dae,Park, Sung Young The Royal Society of Chemistry 2017 Journal of materials chemistry. B, Materials for b Vol.5 No.34
<P>We describe a novel synthesis method for silica nanoparticles, which involves a combination of these nanoparticles with targetable and nontargetable fluorescent dopamine-conjugated hyaluronic acid (HA-DA) <I>via</I> rational chemical dehydration. The resulting HA-decorated silica fluorescent nanoparticles, electrostatically linked to polyaniline (PANI) to form ionic complexes, possessed high fluorescence intensity and were monodisperse in solution, near-infrared light responsive, and amenable to specific labeling of cancer cell lines. When exposed to near-infrared irradiation, the fluorescent silica nanoparticles exerted photothermal cytotoxicity guided by bioimaging and distinguished malignant cancer cells from normal cells <I>via</I> receptor CD44. Different heating properties of nanoparticles depend on local interactions between different structures, and determination of their efficacy could lead to new thermal treatment options such as noninvasive photothermal therapy.</P>
Mazrad, Zihnil Adha Islamy,Choi, Cheong A,Kwon, Yong Min,In, Insik,Lee, Kang Dae,Park, Sung Young American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.38
<P>The ability to quickly detect and kill bacteria is crucial in the realm of antibiotic resistance. In this study, we synthesized a detection probe consisting of polyethylenimine (PEI)-passivated polydopamine-based fluorescent carbon (FDA:PEI) nanoparticles, generating a cationic adhesive material for bacterial detection that is surface-coatable, photothermal, and antibacterial. The cationic FDA:PEI nanoparticles effectively bound to the anionic bacterial cell wall, resulting in a dramatic quenching effect visible in fluorescence spectra and confocal images. In this fluorescence on/off system, FDA:PEI nanoparticles showed similar bacterial detection abilities between aqueous- and solid-phase assays. Scanning electron microscopy clearly showed the attachment of FDA:PEI nanoparticles to the surface of bacteria, both in solution and as a coating on the surface of a polypropylene film. In addition to detection, this versatile material was found to have an antibacterial potential, via near-infrared irradiation to induce a heat release, killing bacteria by thermolysis. Thus, by exploiting the cationic and catechol moieties on the surface of polydopamine carbon dots, we developed a novel bacterial-detection platform that can be used in a broad range of conditions.</P>
Mazrad, Zihnil Adha Islamy,Lee, Kyueui,Chae, Ari,In, Insik,Lee, Haeshin,Park, Sung Young The Royal Society of Chemistry 2018 Journal of Materials Chemistry B Vol.6 No.8
<P>In the past decade, fluorescent carbon nanoparticles (FNPs) prepared from natural resources and biomaterials have been attractive due to their various properties, such as unique optical properties, great biocompatibility, water dispersion, and facile surface functionalization. Depending on the properties of the carbon sources and the subsequent carbonization processes, internal/external stimuli responsive carbon nanoparticles have been generated that are useful for theranostic and sensing applications. In this review, we highlight the recent developments in the use of FNPs in nanomedicine in great detail, particularly for FNPs responding to internal stimuli, including redox, pH, and enzymes, and external stimuli, including temperature, light, and magnetic fields, for drug delivery and sensing applications. Furthermore, we hope to provide insight that could stimulate further research aiming for unparalleled useful applications. As a result, there are many possibilities that can be explored from this smart material.</P>
Islamy Mazrad, Zihnil Adha,In, Insik,Lee, Kang-Dae,Park, Sung Young Elsevier 2017 Biosensors & bioelectronics Vol.89 No.2
<P><B>Abstract</B></P> <P>A fluorescent dye and a photothermal agent were grafted onto a cationic polymer for rapid and simple bacteria detection in liquid and solid phase based fluorescence on/off. The integrated poly(vinylpyrrolidone) (PVP) backbone with catechol and bromoethane moieties possesses unique optical properties due to the presence of boron dipyrromethane (BODIPY) and near infared NIR-responsive IR825 (F-PVP). The cationic segments showed distinct fluorescence quenching patterns after interaction with gram-positive and gram-negative bacteria via polyion complex interactions. Fluorescence quenching depended on direct interaction of the bacterial cell membrane, as confirmed using SEM and confocal imaging. The detection limit was 1mg/mL for the liquid-phase assay and the minimal detectable concentration of bacteria using the solid-phase assay was 10<SUP>6</SUP> CFU/mL. After bacterial detection in contaminated area, our system can directly kill bacteria via the photothermal conversion ability of the IR825 substituent using NIR exposure by polymer solution and limited in coated PP. Finally, the proposed biosensor is capable as potential material for detection of bacteria in simple liquid and solid phase assay.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Biosensor with rapid and simple assay to bacteria is showed by polyion interaction. </LI> <LI> The fluorescent on/off system are shown coated surface and liquid state. </LI> <LI> The coated surface can be a potential material for detection signal as litmus paper. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>The boron dipyrromethane and near infared-responsive IR825 was integrated in PVP polymer as excellent potential fluorescence On/Off system for detection of bacteria not only in liquid but also in coated surface assay.</P> <P>[DISPLAY OMISSION]</P>
Coated Surface Phase Bacteria Detection Assay Using a Fluorescent Polymer
( Zihnil Adha Islamy Mazrad ),박성영 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
We studied the combined design polymer to obtain dual functions for both detection and killing bacteria. Our integrated polyvinylpyrolidone (PVP) backbone with catechol and bromoethane moieties showed tunable fluorescence behavior due to the presence of boron dipyrromethane (BODIPY) and near infared NIR-responsive IR825 (F-PVP). The cationic segments showed distinct fluorescence quenching after interaction with gram-positive and negative bacteria via polyion complex interactions confirmed using SEM and confocal imaging with the detection limit 1 mg/mL for the liquid-phase assay. We demonstrated detection bacteria using coated surface polypropylene (PP) phase assay showing fluorescence quenching. The solid-phase assay can be used to detect bacteria much as litmus paper. More advances, this agent can directly kill bacteria via the photothermal conversion ability using NIR exposure. <sup>**</sup>This study was supported by Korea National University of Transportation at 2016.
( Zihnil Adha Islamy Mazrad ),이운한,박성영 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Injectable and temperature-sensitive hydrogels were synthesized based on dopamine end-capped Pluronic (Plu-DP) and 2-chloro-3′,4′-dihydroxyacetophenone-quaternized poly[(dimethyl aminoethyl methacrylate)-co-(t-butylmethacrylate)] for tissue engginering material. The catechol -functionalized polymer crosslinked hydrogels exists in a viscous solution state at room temperature, but becomes a gel via in situ crosslinking at body temperature. This material is stable and the temperature-sensitive 14:8 wt% ratio and showed reversible sol-gel transition behavior within 10 s, presenting excellent mechanical properties and gel stability. In conclusion, this hydrogel can be applied for drug delivery and tissue engineering in biomedical application. This work was supported by Korea National University of Transportation in 2017.
( Zihnil Adha Islamy Mazrad ),박성영 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
We report fabrication exfoliation of montmorillonite (MMT) using 2-chloro-3`, 4`-dihydroxyacetophenone (CCDP) and 1,3-propanesultone quaternized poly(dimethyl amino)ethyl methacrylate [(C/S)-q-PDMA]. The catechol in this platform allowed easy access to surface coatings to incorporate an antifouling capability, confirmed by contact angle, XPS measurements and HeLa cell detachment. To more advance this system, we are incorporated active near-infrared (NIR) tungsten oxide (WO<sub>3</sub>) and iron oxide (Fe<sub>3</sub>O<sub>4</sub>) in MMT followed by appropriate material characterization. Metal oxides-immobilized MMT showed colloidal stability and photothermal effect, due to magnetic Fe<sub>3</sub>O<sub>4</sub>, the nanocomposites showed reusable behavior for killing both strains bacteria within 4 min of NIR irradiation. Finally, this approaching is promising coating composite for antifouling material and effective and stable composite for killing bacteria. <sup>**</sup>This study was supported by Korea National University of Transportation at 2016.