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RISS 인기검색어
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- 저자 : Masoumeh Haghbin Nazarpak (검색결과 2 건)
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Ghazal Belgheisi,Masoumeh Haghbin Nazarpak,Mehran Solati‑Hashjin 한국섬유공학회 2023 Fibers and polymers Vol.24 No.9
Currently, material synthesis and processing developments allow the design of increasingly advanced scaffolds for bone tissue engineering. The purpose of this study is to fabricate hybrid scaffolds by embedding electrospun polycaprolactone (PCL) or layered double hydroxides (LDH)/PCL nanofiber mats into 3D printed circular PCL grids with 400 µm strands using a PCL solution as glue. Structural analysis revealed that LDH increased surface roughness in PCL mats in addition to reducing fiber diameter. FESEM images showed that the size of the 3D printed strands and pores was about the same as in the original design, and nanofiber mats were flawlessly placed between the 3D printed grids. The porosity of the scaffolds was determined through BET analysis. Young’s modulus of the scaffolds was determined using a compressive test conducted in dry and wet conditions. Hybrid scaffolds with LDH/PCL nanofiber mats showed significantly higher Young’s modulus than 3D printed grids and hybrid scaffolds with PCL nanofiber mats (P < 0.05). In vitro studies showed the positive effect of LDH on enhancing hybrid scaffolds’ bioactivity and biodegradation rate. The calcium/phosphate ratio in the hybrid scaffold containing LDH was closer to the stoichiometric calcium/phosphate ratio in natural bone. MG-63 cell lines were cultured to assess the scaffold’s biocompatibility. Cell adhesion, alkaline phosphatase activity, and calcium deposition were significantly enhanced in hybrid scaffolds with LDH/PCL nanofiber mats. Considering the results, this hybrid scaffold exhibits favorable bone tissue engineering characteristics.
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Jhamak Nourmohammadi,Meghdad Hadidi,Masoumeh Haghbin Nazarpak,Mona Mansouri,Maede Hasannasab 한국섬유공학회 2020 Fibers and polymers Vol.21 No.3
The herbal drug incorporated nanofibers with potential accelerating wound healing has become a promisingwound dressing to treat wounds. The present research aimed to study the effects of adding different amounts of ElaeagnusAngustifolia (EA) extract on physical, mechanical, and biological properties of silk fibroin-polyvinyl alcohol (SF-PVA)nanofibers. Thus, different electrospun mats were made by changing the SF to the EA ratio. The successful incorporation ofEA in SF-PVA nanofibers was confirmed by Fourier transform infrared spectroscopy (FTIR). No obvious change wasobserved in the mean fiber diameter except for EA/SF ratio 1:3. Also, mechanical properties results showed that the ultimatetensile strength of samples dropped from 9±0.8 MPa to 2.50±0.03 MPa with decreasing SF amount. The in vitro releasestudies indicated that the fickian diffusion controlled the EA release profile and it was faster in the nanofibers containingmore EA. Furthermore, the addition of EA into the nanofibrous dressings improved their antioxidant activity as well asantibacterial activity against both gram-positive (S. aureus) and gram- negative (E. coli) bacteria. Cell viability was alsomeasured using fibroblast cells cultured on prepared dressings and results proved that the higher amounts of EA have asignificant impact on cell viability. These findings suggest the advantages of EA as an additive to regulate cell behavior andfor skin tissue regeneration.
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