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Tsunaki Nukaya,Masaki Yahata,Kensaku Suzuki,Kiichi Yasuda,Hisato Kunitake,Haruki Komatsu,Hiroo Mukai,Hisashi Harada,Toshihiko Takagi 한국원예학회 2009 Horticulture, Environment, and Biotechnology Vol.50 No.3
Autotetraploidy (2n=4X=36) five lines of Meiwa kumquat (Fortunella crassifolia Swingle, 2n=2X=18), which had been induced by treating the nucellar embryos with colchicines, were selected and investigated to determine the fruit characteristics. The fruit weight of tetraploid plants was heavier than that of diploid plants. The percentage of pericarp weight per fruit in tetraploid plants increased significantly compared to that of diploid plants. The sugar content in pericarp of tetraploid plants was significantly higher than that of diploid plants. The organic acid content of tetraploid plants was almost equal to that of diploid plants. Thus, it can be concluded that tetraploidy enhanced desirable traits such as larger fruit size with thicker pericarp and high sugar content in Meiwa kumquat.
Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice
( Jin Imai ),( Takashi Yahata ),( Hitoshi Ichikawa ),( Abd Aziz Ibrahim ),( Masaki Yazawa ),( Hideaki Sumiyoshi ),( Yutaka Inagaki ),( Masashi Matsushima ),( Takayoshi Suzuki ),( Tetsuya Mine ),( Kiyo 대한장연구학회 2020 Intestinal Research Vol.18 No.2
Background/Aims: Intestinal fibrosis is a major complication of Crohn’s disease (CD). The profibrotic protein transforming growth factor-β (TGF-β) has been considered to be critical for the induction of the fibrotic program. TGF-β has the ability to induce not only the expression of extracellular matrix (ECM) including collagen, but also the production of plasminogen activator inhibitor-1 (PAI-1) that prevents enzymatic degradation of the ECM during the onset of fibrotic diseases. However, the significance of PAI-1 in the developing intestinal fibrosis has not been fully understood. In the present study, we examined the actual expression of PAI-1 in fibrotic legion of intestinal inflammation and its correlation with the abnormal ECM deposition. Methods: Chronic intestinal inflammation was induced in BALB/c mice using 8 repeated intrarectal injections of 2,4,6-trinitrobenzene sulfonic acid (TNBS). TM5275, a PAI-1 inhibitor, was orally administered as a carboxymethyl cellulose suspension each day for 2 weeks after the sixth TNBS injection. Results: Using a publicly available dataset (accession number, GSE75214) and TNBS-treated mice, we observed increases in PAI-1 transcripts at active fibrotic lesions in both patients with CD and mice with chronic intestinal inflammation. Oral administration of TM5275 immediately after the onset of intestinal fibrosis upregulated MMP-9 (matrix metalloproteinase 9) and decreased collagen accumulation, resulting in attenuation of the fibrogenesis in TNBS-treated mice. Conclusions: PAI-1-mediated fibrinolytic system facilitates collagen degradation suppression. Hence, PAI-1 inhibitor could be applied as an anti-fibrotic drug in CD treatment. (Intest Res 2020;18:219-228)