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박용덕,조자원,서우석,박해훈,신승철,Hiroshi Sano,Masaki Kambara 대한예방치과학회 2010 International Journal of Clinical Preventive Denti Vol.6 No.2
Objective: The purpose of this clinical study is to determine the effect of dentifrice containing 0.05% Isopropyl methylphenol (IPMP) and 0.05% Dipotassium glycyrrhizinate (GK2) on improvement of gingivitis related symptoms. Materials and Method: Double blind clinical study was carried out in 120 healthy Korean adults to evaluate the improvement effect of test dentifrices for 3 month. All subjects (range of age: 23-35) were randomly assigned into 4 groups, 1) control (without both IPMP and GK2), 2) 0.05% IPMP/ 0.05% GK2 group, 3) 0.05% IPMP group and 4) 0.05% GK2 group. All subjects were provided with their assigned test dentifrice and soft-bristled toothbrush for home use. Subjects were instructed to brush their teeth for 3 minutes three times daily using only the dentifrice and toothbrush provided. Results: After 3 month test period, IPMP/GK2 group showed statistically significant (p<0.05) reductions for halitosis (17.5%), Plaque index (36.5%), gingival crevicular fluid (34.7%), periodontal pocket depth (13.1%), and Gingival index (16.0%) compared to control group. Conclusion: The dentifrice containing of 0.05% IPMP and 0.05% GK2 showed the most efficient in improving the gingivitis related symptoms. These findings might suggest that a combination of IPMP and GK2 showed a synergistic effect or special mode of action.