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RISS 인기검색어
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- 저자 : Masahiko Kimura (검색결과 3 건)
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Antiferromagnetic Transition in Ru2CrSi in Magnetic Fields
Masahiko Hiroi,Kaori Uchida,Iduru Shigeta,Masakazu Ito,Keiichi Koyama,Shojiro Kimura,Kazuo Watanabe 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
In the Heusler compound Ru2CrSi, an antiferromagnetic transition at TN =14 K was revealed byspecific heat and magnetization measurements. In this study the electrical resistivity is measured inmagnetic fields up to 14.5 T, and the antiferromagnetic transition in magnetic fields is investigated. In the temperature dependence of the resistivity at zero field, a clear dip at 15 K and a humpwith a maximum at 9 K are observed. This dip is considered to be due to the antiferromagnetictransition. With increasing magnetic field, the magnitude of the resistivity slightly increases aroundTN; i.e., a positive magnetoresistance is observed. The temperature dependence of the resistivityis hardly affected by increasing the magnetic field. The transition temperature decreases only by 0.3 K even with applying 14.5 T. These results demonstrate that the antiferromagnetic state inRu2CrSi is unusually unaffected by a strong magnetic field.
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Yoshihiko Fujita,Masahiko Kimura,Hiroki Sato,Toshikazu Takata,Nobufumi Ono,Kazuto Nishio 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6
Rotaxanes comprise a class of interlocked moleculescontaining a wheel threaded onto an axle with blockinggroups on the ends to keep thewheel fromsliding off.Here,weshow that [2][bis(2-(3,5-dimethylphenylcarbonyloxy)ethyl)ammoniumtrifluoromethanesulfonate]-[dibenzo-24-crown-8]rotaxane (TRO-A0001), a rotaxane compound, exerted agrowth inhibitory effect on several human cancer cell lines.AnMTT assay revealed an IC50 of 14-830 nMfor TRO-A0001 inthese cells. Neither the wheel nor the axle part alone inhibitedtumor cell growth, suggesting that the complete rotaxanemolecule with its unique ‘‘intramolecular mobility’’ is requiredto inhibit cell growth. Annexin-V/PI staining provided evidenceof the induction of apoptosis, which was further confirmedby the observation of poly (ADP-ribose) polymerasecleavage. Furthermore, a cell cycle analysis using flowcytometry showed that TRO-A0001 treatment resulted in G1arrest in glioblastoma T98G and melanoma G361 cells. Animmunoblot analysis revealed that in both cell lines, TROA0001treatment caused the induction of p21/Cip1, therebydown-regulating Cdks 2, 4 and 6 and reducing Cyclins D1 andE. The results presented in this study demonstrate cytotoxicityof the rotaxane compound and its potential as a lead compoundfor the development of a chemotherapeutic agent againstcancer.
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Anatomy of zebrafish cerebellum and screen for mutations affecting its development
Bae, Young-Ki,Kani, Shuichi,Shimizu, Takashi,Tanabe, Koji,Nojima, Hideaki,Kimura, Yukiko,Higashijima, Shin-ichi,Hibi, Masahiko Elsevier 2009 Developmental biology Vol.330 No.2
<P><B>Abstract</B></P><P>The cerebellum is important for the integration of sensory perception and motor control, but its structure has mostly been studied in mammals. Here, we describe the cell types and neural tracts of the adult zebrafish cerebellum using molecular markers and transgenic lines. Cerebellar neurons are categorized to two major groups: GABAergic and glutamatergic neurons. The Purkinje cells, which are GABAergic neurons, express parvalbumin7, carbonic anhydrase 8, and aldolase C like (zebrin II). The glutamatergic neurons are <I>vglut1</I><SUP><I>+</I></SUP> granule cells and <I>vglut2</I><SUP><I>high</I></SUP> cells, which receive Purkinje cell inputs; some <I>vglut2</I><SUP><I>high</I></SUP> cells are eurydendroid cells, which are equivalent to the mammalian deep cerebellar nuclei. We found <I>olig2</I><SUP><I>+</I></SUP> neurons in the adult cerebellum and ascertained that at least some of them are eurydendroid cells. We identified markers for climbing and mossy afferent fibers, efferent fibers, and parallel fibers from granule cells. Furthermore, we found that the cerebellum-like structures in the optic tectum and antero-dorsal hindbrain show similar Parvalbumin7 and Vglut1 expression profiles as the cerebellum. The differentiation of GABAergic and glutamatergic neurons begins 3?days post-fertilization (dpf), and layers are first detectable 5?dpf. Using anti-Parvalbumin7 and Vglut1 antibodies to label Purkinje cells and granule cell axons, respectively, we screened for mutations affecting cerebellar neuronal development and the formation of neural tracts. Our data provide a platform for future studies of zebrafish cerebellar development.</P>
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