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- 저자 : Mark S. Schlissel (검색결과 2 건)
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Abelson Virus Transformation Prevents TRAIL Expression by Inhibiting FoxO3a and NF-${\kappa}$B
Wilson, Mary K.,McWhirter, Sarah M.,Amin, Rupesh H.,Huang, Dan,Schlissel, Mark S. Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.4
The Abelson Murine Leukemia Virus (A-MuLV) encodes v-Abl, an oncogenic form of the ubiquitous cellular nonreceptor tyrosine kinase, c-Abl. A-MuLV specifically transforms murine B cell precursors both in vivo and in vitro. Inhibition of v-Abl by addition of the small molecule inhibitor STI-571 causes these cells to arrest in the G1 phase of the cell cycle prior to undergoing apoptosis. We found that inhibition of v-Abl activity results in upregulation of transcription of the pro-apoptotic TNF-family ligand tumornecrosis factor-related apoptosis-inducing ligand (TRAIL). Similarly to BCR-Abl-transformed human cells, activation of the transcription factor Foxo3a led to increased TRAIL transcription and induction of a G1 arrest in the absence of v-Abl inhibition, and this effect could be inhibited by the expression of a constitutively active AKT mutant. Multiple pathways act to inhibit FoxO3a activity within Abelson cells. In addition to diminishing transcription factor activity via inhibitory phosphorylation by AKT family members, we found that inhibition of IKK${\beta}$ activity results in an increase in the total protein level of FoxO3a. Furthermore overexpression of the p65 subunit of NF-${\kappa}$B results in an increase in TRAIL transcription and in apoptosis and deletion of IKK${\alpha}$ and ${\beta}$ diminishes TRAIL expression and induction. We conclude that in Abelson cells, the inhibition of both NF-${\kappa}$B and FoxO3a activity is required for suppression of TRAIL transcription and maintenance of the transformed state.
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Abelson Virus Transformation Prevents TRAIL Expression by Inhibiting FoxO3a and NF-kappa B
Mary K. Wilson,Sarah M. McWhirter,Rupesh H. Amin,Dan Huang,Mark S. Schlissel 한국분자세포생물학회 2010 Molecules and cells Vol.29 No.4
The Abelson Murine Leukemia Virus (A-MuLV) encodes v-Abl, an oncogenic form of the ubiquitous cellular non-receptor tyrosine kinase, c-Abl. A-MuLV specifically trans-forms murine B cell precursors both in vivo and in vitro. Inhibition of v-Abl by addition of the small molecule inhibi-tor STI-571 causes these cells to arrest in the G1 phase of the cell cycle prior to undergoing apoptosis. We found that inhibition of v-Abl activity results in upregulation of tran-scription of the pro-apoptotic TNF-family ligand tumor-necrosis factor-related apoptosis-inducing ligand (TRAIL). Similarly to BCR-Abl-transformed human cells, activation of the transcription factor Foxo3a led to increased TRAIL transcription and induction of a G1 arrest in the absence of v-Abl inhibition, and this effect could be inhibited by the expression of a constitutively active AKT mutant. Multiple pathways act to inhibit FoxO3a activity within Abelson cells. In addition to diminishing transcription factor activity via inhibitory phosphorylation by AKT family members, we found that inhibition of IKK activity results in an increase in the total protein level of FoxO3a. Furthermore over-expression of the p65 subunit of NF-B results in an in-crease in TRAIL transcription and in apoptosis and deletion of IKK and diminishes TRAIL expression and induction. We conclude that in Abelson cells, the inhibition of both NF-B and FoxO3a activity is required for suppression of TRAIL transcription and maintenance of the transformed state.
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